Melanie

(9/9) It was a great pleasure working on this with Morgan Morgan, Ilan Libedinsky, Chloe Austerberry, Sander Begeer, @dr_appie, @Gelironald and Tinca Polderman

(8/9) To conclude, due to inconsistent associations and limited generalizability, the autism polygenic score does not have clinical utility and should only be applied for scientific purposes. Improvements are needed for a deeper understanding of autism’s polygenic underpinnings

(1/9) 📣 OUT NOW! 📣 So excited to share that our systematic review and meta-analysis on the autism polygenic score is now published in @JAACAPOpen doi.org/10.1016/j.jaac… A (long) thread of our main findings ⤵️

📢Out Now 📢 In a GWAS meta-analysis, @Gelironald and colleagues identified 11 independent genome-wide significant loci associated with age at onset of walking. in @NatureHumBehav tinyurl.com/4m5twe46

Fully funded PhD studentship available! Join our lab investigating genetic and environmental influences on early child behaviour. Gain transferable skills in scientific enquiry, coding, writing, presenting & more, deadline June 15th tinyurl.com/4faejtsm RTs appreciated!

A review and meta-analysis of studies that assess the relationship between the autism polygenic score and autism diagnosis, and autistic, behavioral and neurobiological traits: medrxiv.org/content/10.110… Led by @MMPdeWit 🧬🧠

@Floris_Huider @YMilaneschi @brenda_penninx @VU_FGB @NTRscience @BBMRINL Amazing work, congrats!

The cohort profile of our BIObanks Netherlands Internet Collaboration (#BIONIC) has been published! We describe the #GWAS dataset of >66,000 Dutch subjects to study the genetic basis of #Depression. doi.org/10.1017/thg.20…. A huge thank you to the cohorts that have contributed!

Out now! The profile article of our BIObanks Netherlands Internet Collaboration (#BIONIC) project, a #GWAS dataset of >66,000 🇳🇱 subjects to study the genetic base of #Depression. Big shoutout to @Floris_Huider for his great work on the data and the paper: bit.ly/3vgIH6u

With many thanks to my amazing team of co-authors @morganjmorgan @ILibedinsky @ChloAusterberry @SanderBegeer @dr_appie @Gelironald and @tincatwin

We conclude that the current autism polygenic score is consistently associated with autism diagnostic status and autistic traits, but overlap between autism and other traits and conditions is not, from publications to date, explained significantly by the autism polygenic score.

📢Our preprint is online! 📢 Systematic Review and Meta-Analysis: Research using the Autism Polygenic Score medrxiv.org/content/10.110…