@MTC_KI

From @NillaKH lab - Personalized immunoglobulin genotyping coupled with monoclonal antibody engineering identifies germline-encoded polymorphisms that influence our anti-viral B cell response. @MTC_KI #MTCPubs doi.org/10.1016/j.immu…

In this review, Marie Arsenian Henriksson and colleagues discuss the potential of mitochondria as a target for precision medicine in cancer, presenting current inhibitors and challenges, and highlighting those enzymes that are attractive targets. #MTCPubs nature.com/articles/s4141…

Marie Arsenian-Henriksson and colleagues show that a combination therapy that activates three nuclear hormone receptors (GR, ERα and RARα) leads to neural differentiation, metabolic reprogramming and reduced tumour burden in neuroblastoma #MTCPubs jeccr.biomedcentral.com/articles/10.11…

New roles of noncoding RNAs in cancer cells are uncovered. Here, @ClaudiaKutter and colleagues show that LINC00326 interacts with a noncanonical #RBP to impair liver cancer cell growth by altering lipid metabolism. #MTCPubs gut.bmj.com/content/71/10/…

Balanced anticodons-codon pools control translation. At the single cell level, @ClaudiaKutter and colleagues found that most cell types exhibit even anticodon-codon pools but increased translation efficiency in neurons. #MTCPubs genome.cshlp.org/content/32/1/9…

Ute Römling and colleagues show that a single amino acid substitution Q329R in the patatin-like phospholipase CapV leads to functional plasticity, which consequently transforms cell morphology and bacterial physiology #MTCPubs nature.com/articles/s4152…

Paper alert - Maria Johansson and colleagues show that mouse NK cell inhibitory receptor repertoire skewing is observed already in bone marrow and propose a model for how repertoire skewing is established. #MTCPubs journals.aai.org/jimmunol/artic…

@JunjieMa4 @jonatcoquet and colleagues describe the diversity of T helper cells in nasal polyps at the clonal level. They distinguish that a subset of Th2 cells in polyp tissue expresses CD109 and produces IL-10, reminiscent of Tr1 cells. @MTC_KI #MTCPubs

Manuel Patarroyo and colleagues demonstrate a role for laminin alpha 5 in mammary gland remodelling. @MTC_KI #MTCPubs …urnals-biologists-com.proxy.kib.ki.se/dev/article/14…

Maria Ruiz Perez and colleagues show that neuroblastoma, which originates from embryonic precursor cells, undergoes neural differentiation upon inhibition of fatty acid synthesis, a metabolic pathway frequently activated in human cancer. @MTC_KI #MTCPubs cell.com/iscience/fullt…

Immunoglobulin germline genes exhibit extensive allelic diversity between individuals. @NillaKH and colleagues characterise this diversity in macaques to provide insights into Ig loci evolution and the development of antibody responses. @MTC_KI #MTCPubs cell.com/immunity/fullt…

Long noncoding RNAs remodel molecular responses. Here, @ClaudiaKutter and colleagues found that the oncogenic LINC01268 promotes liver cancer via MAPK/NFkB signalling. #MTCPubs @MTC_KI dovepress.com/high-expressio…

Anders Björkman and Ulrika Morris provide an explanation for intriguing recent findings of frequent asymptomatic P falciparum malaria infections in areas with low herd immunity @MTC_KI #MTCPubs cell.com/trends/parasit…

Mobile elements constantly remodel genomes. Here, @ClaudiaKutter et al. show that transposons give rise of new tRNA genes to improve translation efficiency. #MTCPubs @MTC_KI academic.oup.com/gbe/article/13… academic.oup.com/gbe/article/13…

Galina Selivanova and colleagues publish that p53 activation can boost the immune response to cancers! @MTC_KI #MTCPubs cancerdiscovery.aacrjournals.org/content/early/…

Our work on ”Regulatory RNA and its association to invasive meningococcal diseases” is now out in @LancetMicrobe . 😊Our SEM picture is the cover picture too. Very proud of the group! @JensKarlsson11 @strategiskaSSF @KAWstiftelsen @karolinskainst @MTC_KI thelancet.com/journals/lanmi…

Yihai Cao and colleagues use zebrafish to visualise how human cancers are killed! #MTCPubs pnas.org/content/117/37…

Yihai Cao and colleagues demonstrate that concomitant targeting of VEGF and PDGF can inhibit growth of FGF2+ cancers #MTCPubs nature.com/articles/s4146…

Elena Kashuba and colleagues describe that the ribosomal protein S18-2 promotes cell stemness #MTCPubs pnas.org/content/117/27…

Trouble getting huge plasmids into cells? @ClaudiaKutter and colleagues describe a method which makes this infinitely easier! #MTCPubs nature.com/articles/s4200…