Maria Andrianova
15 posts
@MaAndrianova
Cancer cell biology | Mutagenesis & repair | postdoc in # @bbglab @IRBbarcelona
💡Five key factors predict the response of #cancer patients to #immunotherapy ✍️ @fmuinos @abel_gonzalezp @nlbigas et al. 📰@NatureGenet ➡️bit.ly/3XDCxJ3 📌DOI: 10.1038/s41588-024-01899-0 #IRBScience #CancerResearch
📢 Very happy to share our latest paper Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis, just published in Cancer Discovery Explore our findings here: aacrjournals.org/cancerdiscover… 🩸🧬💻
Finally published. In this paper we showed that despite heterozygous exonuclease deficiency of pold1 has a minor effect on the germline and somatic mutation rate. Homozygous deficiency increase mutation rate by 2 orders of magnitude and causes cancer nature.com/articles/s4143…
The model. To predict probability of a mutation in certain position we accounted for 6 surrounding nucleotides, direction of replication and transcription, expression level, and local mutation rate and spectra. We trained Roulette on recurrency corrected rare SNVs from GNOMAD
#ICYMI The first episode of 'A Bug In The System' features @imartincorena and @ATJCagan who discuss genetic mutations & how they accumulate, naked mole rats, and how #cancer varies across species. 🎧Check it out via @BBCSounds bbc.co.uk/sounds/play/m0…
Our preprint about the role of POLD1 deficiency in soma and germline mutations is out. biorxiv.org/content/10.110… Two main findings: surprisingly, POLD1 deficiency has a recessive effect on mutation rate; POLD1 alters mutational spectra to the same degree in soma and sperm
