Maerkl Lab

Maria's paper on characterizing trans-properties of transcription factors and how they affect gene expression is out now! biorxiv.org/content/10.648…

Saeed's latest paper is now out on bioRxiv: "PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized non-ribosomal proteins" biorxiv.org/content/10.648…

Check out Amogh's latest review: "Microfluidics meets cell-free systems: from molecular engineering to synthetic cells" now published in Current Opinion in Biotechnology. sciencedirect.com/science/articl…

Laura and Jiami's paper is out now on BioRxiv! Nice collaboration with the Reddy lab at ETHZ: "High-throughput cell-free profiling of SARS-CoV-2 RBD variants enables rapid and quantitative in vitro affinity landscape mapping." biorxiv.org/content/10.110…

The Maerkl Lab is now on Bluesky (better late than never as they say...)! bsky.app/profile/maerkl…

Fanjun and Amogh's paper is now published: "Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system" nature.com/articles/s4146…

Pao-Wan, Saeed and Matthis' paper is out now on BioRxiv: "A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications" biorxiv.org/content/10.110…

Fanjun and Amogh's paper is out now on BioRxiv: "Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system." biorxiv.org/content/10.110…

Laura and Laura's paper is out now in ACS Synthetic Biology. "Long-Term Protein Synthesis with PURE in a Mesoscale Dialysis System" pubs.acs.org/doi/full/10.10…

Pao-Wan's review on cell-free regulatory components is out now! Regulatory Components for Bacterial Cell-Free Systems Engineering | ACS Synthetic Biology pubs.acs.org/doi/10.1021/ac…

Laura (@SuNMIL_EPFL) and Laura's paper on running the PURE system for weeks using a simple mesoscale dialysis system is now on bioRxiv!! "Long-term protein synthesis with PURE in a mesoscale dialysis system" biorxiv.org/content/10.110…

The Maerkl Lab is hiring one or two graduate students to work in the area of cell-free synthetic biology, specifically synthetic cell engineering! Deadline for our EDBB doctoral program is Nov 1st ... See below for more information: eth-gethired.ch/de/jobs/detail…

Ragu's paper is now officially out in ACS SynBio: Towards Self-regeneration: Exploring the Limits of Protein Synthesis in the Protein Synthesis Using Recombinant Elements (PURE) Cell-free Transcription–Translation System | ACS Synthetic Biology pubs.acs.org/doi/10.1021/ac…

Laura's paper from the Stellacci lab (@frstella) is out now: Nature-Inspired Recycling of a Protein Mixture into a Green Fluorescent Protein-based hydrogel - now published in RSC Sustainability pubs.rsc.org/en/content/art…

Amogh's comprehensive review of microfluidic approaches and applications in cell-free synthetic biology is out now! #microfluidics #cellfreesynbio #synbio #syntheticbiology frontiersin.org/articles/10.33…

Targeting protein-ligand neosurfaces using a generalizable deep learning approach biorxiv.org/content/10.110…

Ragu's paper describing a minimal PURE system is now on BioRxiv!! Towards self-regeneration: exploring the limits of protein synthesis in the PURE cell-free transcription -translation system biorxiv.org/content/10.110…

Our cellbase.epfl.ch is back up and running! This database contains over 7000 single-cell movies of strains in the yeast-GFP library grown on a microfluidic chemostat under various environmental conditions: pnas.org/doi/abs/10.107…

Congratulations to our post-doc Fanjun who was just awarded a SNF Spark grant! Spark grants fund "rapid testing or development of novel and unconventional scientific approaches, methods, theories, standards and ideas", which is right up our alley! snf.ch/en/8EWqXT6CZ7w…

Laura and Paula's paper is out now! "C2CAplus: A One-Pot Isothermal Circle-to-Circle DNA Amplification System" pubs.acs.org/doi/10.1021/ac…