Mansfeld Lab

UK REDOX NETWORK 2025 Meeting at Institute of Cancer Research, London SW7 3RP28 April 2025. Excellent programme coordinated by Olena Rudyk (KCL) and Joerg Mansfeld (ICR). @SFRR_Europe @kingscardio @elsbiomedchem

Have you ever wondered what H2O2 does in your cells? We are looking a highly motivated #Postdoc to investigate #Redox regulation of #DNAReplication and #DNADamage repair. Our lab is based at the ICR in Chelsea, London, UK. Please apply here: rb.gy/7ddtmh #mansfeldlab

UK REDOX NETWORK Meeting Session 2: Helena Cocheme (Imperial College) introduces Joerg Mansfeld (Institute of Cancer Research) (intranet.sfrr-europe.org/documents/UKRe…; @SFRR_Europe @SFRRAustralasia @SFRBM @CochemeLab @JuliaVorhauser

@MickLab Excellent News. Very happy for you!

Very happy to announce that I have been positively evaluated for tenure and promoted to full professor. Huge thanks to all my mentors, collaborators, supporters and foremost my incredible team, past and present. I couldn't have done this without all of your help.

@DoraTang5 @ERC_Research Congratulations Dora so well deserved!

Really excited to have been awarded a #ERCCoG grant to contribute to @ERC_research. We'll be building synthetic cells to unravel the physical chemistry of living systems. Interested in joining our team? We'll be recruiting soon..

We have several postdoc openings! tu-dresden.de/cmcb/biotec/fo… Our interdisciplinary group works on the #Genomics of #DNAdamage and #Mutagenesis using #ComputationalBiology, #MachineLearning and #AI. (details in following tweets)

An extraordinary paper showing an unexpected redox role for BCAT1 in accurate chromosome segregation. There is clearly something important about how redox changes modulate the cell cycle, especially in mitosis. doi.org/10.1016/j.celr…

How does polymerisation activate the ADP-ribosyltransferase tankyrase? We are a few steps closer to the answer: rdcu.be/c0hLX. Congratulations to the team, and thank you to our funders, especially @CRUKresearch @wellcometrust @ICR_London @ListerInstitute!

@NatrajanLabICR @ICR_London @BreastCancerNow Congratulations Rachael, what a rollercoaster since that Thursday. Well-deserved!!

I am thrilled and honoured to be one of the #ERCStG recipients! So grateful to @ERC_Research, my mentors, colleagues at the @ICR and my family. We will explore the roles of histone acetylation in cancer and will be recruiting soon. erc.europa.eu/news-events/ne…

Many congratulations to Alex Radzishueskaya in our Division who has been awarded an ERC Starting Grant!

Interesting @biorxivpreprint by the group of Ben Cravatt @scrippsresearch with the group of @davidrliu. They use base-editing to assign essentiality to >10,000 cysteines in cancer cell lines. Full post on @joinmastodon @Stephanhacker2@mstdn.science. doi.org/10.1101/2022.1…

The @MansfeldLab just returned from the EMBO “Thiol in oxidation in biology” meeting. Super exciting and at a wonderful place. And @JuliaVorhauser won the POSTERPRIZE. Thanks to Bruce Morgan, Haike Antelmann and @dana_reichmann for organising one of the best workshops this year.

If you're interested in telomeres and DNA replication, check out this amazing postdoc opportunity in Max Douglas's lab ! linkedin.com/posts/max-doug…

The @NerliElisa strikes again! Deterministic and probabilistic fate decisions exist in the same retinal lineage! A tour de force and amazing team effort led and guided by Elisa. She will discuss in more detail, I go on conference and vacation :-). biorxiv.org/content/10.110…

Professor Chris Bakal's lab (@BakalLabICR) show that #Melanoma #SkinCancer cells harness ARHGEF9 - a gene usually used by growing nerves - to drill through surrounding tissues and escape from their immediate area. Read more: icr.ac.uk/news-archive/s…

Our article on a ROS-dependent regulation of CDK2 (doi.org/10.1016/j.devc…) has just been recommended on @FacultyOpinions facultyopinions.com/article/742227… Thanks verybody @MansfeldLab & @BIOTEC_TUD & @ICR_London to make this a worthwile and exciting endeavour.

📢 NEWS: ICR scientists (@MansfeldLab) have discovered how naturally occurring, unstable molecules, known as free radicals, can directly regulate a key protein for cell division called CDK2, opening up a potential new way to target #Cancer 👇 icr.ac.uk/news-features/…

📢 Hot off the press 📢 🧬 Ever wonder why some DNA sequences are difficult to replicate? Using reconstituted replisomes we revealed that structure-forming repeats induce robust replication stalling and uncovered structure-specific recovery mechanisms: nature.com/articles/s4146…

@PinesLab Thank you :-) Happy to be part of the team @ICR_London!

Congratulations to Jörg Mansfeld and colleagues on identifying a link between the redox state of a cell and the decision to replicate. Implications for the tumour micro environment and radiation therapy.

A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase cell.com/developmental-…