Margaret Wheless, MD

#PostTest Q2️⃣ #TumorBoardTuesday 👉🏽 Free CME 🔗 integrityce.com/TBT2025 🧐 Your patient w/ localized MSI-H CRC achieves a cCR after 12 mo of pembrolizumab and opts for organ-sparing surveillance. Which counseling point is most important regarding immune-related AEs in this setting❓

#PostTest Q1️⃣ #TumorBoardTuesday 👉🏽#CME Eval 🔗 integrityce.com/TBTeval25 👉🏽ALL CME🔗 integrityce.com/TBT2025 65yo ♂️ dx w/ stage 4b CRC w/ bulky lymphadenopathy on CT. Tumor testing shows dMMR/MSI-H. He wants to avoid surgery if possible. Which of the following is the most evidence-supported management strategy?

#TumorBoardTuesday It is not often that we get to talk about "dramatic" improvements in the care of out #GIcancer patients But immunotherapy for MSI-H #colorectalcancer has been truly transformational💙 📢Join us Tuesday, 02-03-26 at 8PM ET as @KristenCiombor @MargaretWheless 🗣️ICI use for locally advanced #colorectalcancer RT and bring others into the discussion‼️

@MPishvaian @TumorBoardTues @KristenCiombor @IntegrityCE @CathyEngMD @jordanberlin5 @MyriamChalabi @AndreaCercek @VUMCDiscoveries @FASinicropeMD @GIMedOnc @skopetz @michael_overman @marshalj23 @VanMorrisMD @aparna1024 @Chelsie_Sievers I think I would if it was resectable (hoping it is fibrosis!), @KristenCiombor what would you do?

@MargaretWheless @TumorBoardTues @KristenCiombor @IntegrityCE @CathyEngMD @jordanberlin5 @MyriamChalabi @AndreaCercek @VUMCDiscoveries @FASinicropeMD @GIMedOnc @skopetz @michael_overman @marshalj23 @VanMorrisMD @aparna1024 @Chelsie_Sievers #TumorBoardTuesday Hmmm - I misread the last tweet, but what if the residual 5cm mass was still sitting up against the pelvic sidewall. Would you still resect, hoping (with good reason) that the mass is just all fibrosis❓

@MPishvaian @TumorBoardTues @KristenCiombor @IntegrityCE @CathyEngMD @jordanberlin5 @MyriamChalabi @AndreaCercek @VUMCDiscoveries @FASinicropeMD @GIMedOnc @skopetz @michael_overman @marshalj23 @VanMorrisMD @aparna1024 @Chelsie_Sievers Absolutely yes!

@MargaretWheless @TumorBoardTues @KristenCiombor @IntegrityCE @CathyEngMD @jordanberlin5 @MyriamChalabi @AndreaCercek @VUMCDiscoveries @FASinicropeMD @GIMedOnc @skopetz @michael_overman @marshalj23 @VanMorrisMD @aparna1024 @Chelsie_Sievers #TumorBoardTuesday 🤔Now I assume this is a for sure dual ICI case, right❓

@MPishvaian @TumorBoardTues @KristenCiombor @IntegrityCE @CathyEngMD @jordanberlin5 @MyriamChalabi @AndreaCercek @VUMCDiscoveries @FASinicropeMD @GIMedOnc @skopetz @michael_overman @marshalj23 @VanMorrisMD @aparna1024 @Chelsie_Sievers Great question. This was before the dostarlimab data but ended up recommending colo every 6mo initially with imaging every 3-6mo

@MargaretWheless @TumorBoardTues @KristenCiombor @IntegrityCE @CathyEngMD @jordanberlin5 @MyriamChalabi @AndreaCercek @VUMCDiscoveries @FASinicropeMD @GIMedOnc @skopetz @michael_overman @marshalj23 @VanMorrisMD @aparna1024 @Chelsie_Sievers #TumorBoardTuesday 🧐Interesting choice - especially for a 65 year old 🤔What surveillance schedule did you recommend for him after the 1year of pembro❓

@GIMedOnc @TumorBoardTues @KristenCiombor @IntegrityCE @CathyEngMD @jordanberlin5 @MyriamChalabi @AndreaCercek @VUMCDiscoveries @FASinicropeMD @MPishvaian @skopetz @michael_overman @marshalj23 @VanMorrisMD @aparna1024 @Chelsie_Sievers There were truly not enough poll options to list all the possibilities with ICI!

@MargaretWheless @TumorBoardTues @KristenCiombor @IntegrityCE @CathyEngMD @jordanberlin5 @MyriamChalabi @AndreaCercek @VUMCDiscoveries @FASinicropeMD @MPishvaian @skopetz @michael_overman @marshalj23 @VanMorrisMD @aparna1024 @Chelsie_Sievers With that much disease? Can we Ipi nivo x 1 month then nivo 6-12 month with scopes every 3 months? Cause that sounds awesome.