MargolisLab

New data from the Julius Lab show that crosstalk between epithelial tuft cells and enterochromaffin cells drives a gut-brain signal that turns parasite sensing into appetite suppression. Cool stuff! @DJuliusSF @karagm2009 nature.com/articles/s4158…

Congratulations to Dr. Lin Hung from our lab on receiving the 2026 AGA Research Scholar Award for her project on linking GI-derived oxytocin and serotonin to treat DGBI pain—an honor supporting rising researchers in digestive disease research. @karagm2009

In our latest study, we explore how early experiences can shape gut function and pain later in life. Dr.@SarahANajjar breaks it down 👇

We’re excited to launch a new series of posts and videos from the Margolis Lab 🎥 Stay tuned.👀 Our first video drops tomorrow! Dr. @SarahANajjar will be sharing insights on our newly published paper. @karagm2009

Don’t miss Dr. Kara Margolis’ talk this afternoon at #USASP2026 on serotonin signaling in the gut-brain axis! @karagm2009

We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science.

New from our lab: Untreated maternal depression & early-life stress can rewire gut–brain circuits via enteric + sympathetic pathways, leading to long-term changes in gut motility & pain. 🔗 sciencedirect.com/science/articl… @karagm2009 @SarahANajjar @LinYungHung1

Amazing new article from the Thaiss and Levy labs! These data show that gut microbes drive age-related memory loss by disrupting gut-brain signaling. @ChristophThaiss @MaayanLevyPhD @karagm2009 nature.com/articles/s4158…

Chronic inflammation in IBD reshapes the stem cell niche—reducing LGR5⁺ stem cells while expanding OLFM4⁺ immune-responsive populations, revealing epithelial plasticity. @karagm2009 biorxiv.org/content/10.648…

Another promising finding for 5HT4R agonism! This study found that in participants with previous episodes of depression, 5-HT4R agonist, prucalopride, had pro-cognitive effects (learning, memory & attention). @karagm2009 doi.org/10.1016/j.nsa.…

A large cohort study of 126,735 adults followed over 14.5 years show the high prevalence of IBS cases in instances of severe emotional and physical neglect, as well as abuse. @karagm2009 nature.com/articles/s4139…

NEW PREPRINT 🚨 Why does IBS pain persist? PRC’s Nestor Jimenez-Vargas and the Bunnett Lab uncover how PAR2 signaling from endosomes amplifies fleeting histamine signals to sustain colonic nociceptor hyperexcitability. biorxiv.org/content/10.648…

A gut-acting 5-HT4 drug, prucalopride, shows faster antidepressant/anxiolytic effects than fluoxetine in mice, with parallel shifts in the microbiome. @karagm2009 nature.com/articles/s4152…

Food is more than fuel for growing bodies, it may shape developing minds. Higher ultraprocessed food intake in preschool years was associated with more behavioral and emotional symptoms in early childhood. @karagm2009 jamanetwork.com/journals/jaman…

Amazing new study shows how pain-sensing nerves work together with tuft cells of the intestinal epithelium to protect the gut from infection. @karagm2009 nature.com/articles/s4158…

Balancing benefit and risk is key in IBS therapy. Quantifying the ‘number needed to harm’ helps clinicians better evaluate treatment safety. @karagm2009 pubmed.ncbi.nlm.nih.gov/40471839/

New online! Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut dlvr.it/TRFmKq

Gut health finally has a scientific definition. ISAPP’s new consensus defines it as normal GI function without disease or symptoms that affect quality of life. @karagm2009 nature.com/articles/s4157…