MargolisLab

New from our lab: Untreated maternal depression & early-life stress can rewire gut–brain circuits via enteric + sympathetic pathways, leading to long-term changes in gut motility & pain. 🔗 sciencedirect.com/science/articl… @karagm2009 @SarahANajjar @LinYungHung1

Amazing new article from the Thaiss and Levy labs! These data show that gut microbes drive age-related memory loss by disrupting gut-brain signaling. @ChristophThaiss @MaayanLevyPhD @karagm2009 nature.com/articles/s4158…

Chronic inflammation in IBD reshapes the stem cell niche—reducing LGR5⁺ stem cells while expanding OLFM4⁺ immune-responsive populations, revealing epithelial plasticity. @karagm2009 biorxiv.org/content/10.648…

Another promising finding for 5HT4R agonism! This study found that in participants with previous episodes of depression, 5-HT4R agonist, prucalopride, had pro-cognitive effects (learning, memory & attention). @karagm2009 doi.org/10.1016/j.nsa.…

A large cohort study of 126,735 adults followed over 14.5 years show the high prevalence of IBS cases in instances of severe emotional and physical neglect, as well as abuse. @karagm2009 nature.com/articles/s4139…

NEW PREPRINT 🚨 Why does IBS pain persist? PRC’s Nestor Jimenez-Vargas and the Bunnett Lab uncover how PAR2 signaling from endosomes amplifies fleeting histamine signals to sustain colonic nociceptor hyperexcitability. biorxiv.org/content/10.648…

A gut-acting 5-HT4 drug, prucalopride, shows faster antidepressant/anxiolytic effects than fluoxetine in mice, with parallel shifts in the microbiome. @karagm2009 nature.com/articles/s4152…

Food is more than fuel for growing bodies, it may shape developing minds. Higher ultraprocessed food intake in preschool years was associated with more behavioral and emotional symptoms in early childhood. @karagm2009 jamanetwork.com/journals/jaman…

Amazing new study shows how pain-sensing nerves work together with tuft cells of the intestinal epithelium to protect the gut from infection. @karagm2009 nature.com/articles/s4158…

Balancing benefit and risk is key in IBS therapy. Quantifying the ‘number needed to harm’ helps clinicians better evaluate treatment safety. @karagm2009 pubmed.ncbi.nlm.nih.gov/40471839/

New online! Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut dlvr.it/TRFmKq

Gut health finally has a scientific definition. ISAPP’s new consensus defines it as normal GI function without disease or symptoms that affect quality of life. @karagm2009 nature.com/articles/s4157…

This cool new paper reports an important characterization of how enteroendocrine cells in the gut are positioned relative to sensory neurons. Not surprisingly, there are significant regional differences along the GI tract! @karagm2009 onlinelibrary.wiley.com/doi/10.1111/nm…

Interesting preprint showing that the behavioral effects of lithium are mediated by the gut-brain axis! biorxiv.org/content/10.648… @karagm2009

This study maps distinct enteric neuron subtypes and shows how each shapes key intestinal functions—from fecal output to feeding. A big step forward in understanding gut–brain neural circuits. #sec2" target="_blank" rel="nofollow noopener">sciencedirect.com/science/articl… @karagm2009

Enteric Neurons Join the Dialogue on Pain! A recent study reveals that cholinergic circuits within the colon communicate through dorsal root ganglion (DRG) pathways, particularly following inflammation. 👉 cell.com/neuron/fulltex…

The NYU Pain Research Center (PRC) and Department of Molecular Pathobiology at NYU Dentistry are seeking Assistant or Associate Professors in the fields of chronic pain mechanisms, pain therapeutics, and related disciplines. More info and apply: urldefense.proofpoint.com/v2/url?u=https…

📢New paper in Nature Mental Health! Dr @karagm2009 is co-author on a review exploring how the gut microbiota shapes mental health through the gut–brain axis. nature.com/articles/s4422…

Big congratulations to postdoc @SarahANajjar on receiving a NIH K01 award to study serotonergic mechanisms of pain! 👏A huge step toward independence and groundbreaking discoveries ahead! 🥳 @karagm2009

Our amazing mentor and team lead @karagm2009 is now officially Professor Margolis! 👏👩‍🏫 She’s the definition of supportive, visionary, and unstoppable! no one deserves it more! Feeling so lucky to be part of her team 💜 #ProfessorKara #WomenInScience #ProudTeam 💫🌟