Mark A Nicholas

179 posts

Mark A Nicholas banner
Mark A Nicholas

Mark A Nicholas

@Markolas11

Postdoc in the @YttriLab at @CMU_Bio, retired footballer, maker of good food

Katılım Haziran 2020
393 Takip Edilen210 Takipçiler
Sabitlenmiş Tweet
Mark A Nicholas
Mark A Nicholas@Markolas11·
Excited the bulk of my PhD work is now out in @NeuroCellPress If you're interested in how motor cortex and striatum work together for behavior take a look at the tweet print or here tinyurl.com/M1Lesions #neurotwitter #phdlife #neuroscience @CMU_Bio
The Yttri Lab@YttriLab

1/5 NEW in NEURON! We asked what forelimb M1 contributes to striatal and behavioral dynamics. Short answer: almost everything*. @Markolas11 trained mice to perform a joystick reaching task, w/ and w/out a go cue, then lesioned CFA tinyurl.com/M1Lesions @cmuneurosci @CmuScience

English
3
7
22
3.9K
Mark A Nicholas retweetledi
The Yttri Lab
The Yttri Lab@YttriLab·
Huh, it's been 8 months since I was on here. Better late than never. I hope this new-ish paper will challenge people to think about the interpretations of our models STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!) cell.com/cell-reports/f… @CmuScience @cmuneurosci
The Yttri Lab tweet media
English
1
2
8
306
Mark A Nicholas
Mark A Nicholas@Markolas11·
I started studying neuroscience back in 2012. This week I will be defending my PhD from the @YttriLab at @CarnegieMellon If you are interested in the Zoom option, please reach out.
Mark A Nicholas tweet media
English
0
0
3
113
Mark A Nicholas retweetledi
Ryan Cho
Ryan Cho@ryanjhcho·
Excited to share my postdoctoral work, with Ilana Witten and @scott_bolkan at @PrincetonNeuro. TL;DR - we show that two basal ganglia pathways oppositely affect decision-making by very precise control of cortical subpopulations that encode accumulated sensory evidence.
bioRxiv Neuroscience@biorxiv_neursci

Striatal pathways oppositely shift cortical activity along the decision axis biorxiv.org/content/10.110… #biorxiv_neursci

English
11
13
66
6.5K
Mark A Nicholas retweetledi
Laura Grima
Laura Grima@LauraGrimaNeuro·
The first preprint of my postdoc with @jtdudman is now online! Here we wanted to understand the algorithms mice use when learning to forage in large environments with many potential resources. 1/n biorxiv.org/content/10.110…
Laura Grima tweet media
English
3
30
118
14.5K
Mark A Nicholas retweetledi
Vincent Costa
Vincent Costa@VincentCostaPhd·
26 years after Larry Swanson emphasized “the amygdala is neither a structural or functional unit” we used sn-RNAseq to answer the question: “What is the [primate] amygdala?” Check out the preprint 👇 biorxiv.org/content/10.110…
Vincent Costa tweet media
English
13
99
289
78.7K
Mark A Nicholas
Mark A Nicholas@Markolas11·
Hey if you are still around #Sfn24 this afternoon and interested in cell type-specific cortex and striatum concurrent recordings during trial and error learning, come check out our work @YttriLab @SfNtweets #sfn2024
Mark A Nicholas tweet media
English
0
2
12
636
Mark A Nicholas
Mark A Nicholas@Markolas11·
@TrackingActions Although just behavior... Using pupillometry and a rolling stimulus schedule, we found that NHPs could learn the difference in stimulus value within 20 trials of the session and this difference in pupil continued to increase with subsequent sessions. tinyurl.com/mpcbn6dh
Mark A Nicholas tweet media
English
1
0
5
396
Mackenzie Weygandt Mathis, PhD
Mackenzie Weygandt Mathis, PhD@TrackingActions·
What are some of your favorite examples (papers) of within-session learning in animal models (with neural recordings ideally)? This could be zero-shot learning, continual learning, motor adaptation, cognitive dynamic-decision making, etc! Thanks #neuroTwitter #neuroX (Don't hesitate to share your own work! ⬇️)
English
17
9
74
18.3K
Mark A Nicholas retweetledi
Aaron Batista
Aaron Batista@aaronbatista·
When you fail to perform at your best right when it matters the most, what's going on in your brain? We can now provide an explanation: Exceptionally high stakes interfere with motor preparation. We can see this in motor cortex. Next up: finding out why. sciencedirect.com/science/articl…
English
2
13
36
2.8K
Mark A Nicholas retweetledi
Adam
Adam@asmoulder3195·
After some lovely updates thanks to reviewer/editor feedback, this work is now published in Neuron! cell.com/article/S08966… We find monotonic reward signals in M1/PMd, and interactions of reward value with neural reach signals that correlate with an inverted-U in performance
Adam@asmoulder3195

Excited to announce “A neural basis of choking under pressure” is up on biorxiv, where we look at motor cortical population correlates of reward-mediated performance in primates. biorxiv.org/cgi/content/sh… Summary in thread below (1/11)

English
3
12
40
5.8K

Keşfet

@pgmid @SfNtweets @CmuScience @cmuneurosci @YttriLab @CarnegieMellon @scott_bolkan @PrincetonNeuro