Maya Talukdar

@rovingscientist @LeandrosBoukas @PageLabXY @NatureGenet Thank you so much! The sex bias in HSCR is fascinating & have enjoyed reading your + Aravinda's work on it very much! I see sex as another modifier of the HSCR genetic architecture, much as how noncoding variants can modify the effects of rare coding variants

@MayaTalukdar @LeandrosBoukas @PageLabXY @NatureGenet This is an outstanding prespective! I dont work on sex difference per se but on a disease (Hirschprung disease) which shows sex difference .. a mystery yet unsolved.. your ideas and observations are outstanding!Happy to see HSCR in there 😃

Excited to share @PageLabXY and my perspective on the role of the so-called “inactive” X chromosome in autism, out today in @NatureGenet! A quick 🧵… (1/n)

a compelling proposition that the "Xi [is] a genetic suppressor of autosomal mutations" broadly across human diseases (even comes with a tantalizing cameo of a cohesin subunit!)

@PageLabXY @NatureGenet @BeckyEAndersen @ChrisAWalsh1 Full paper here if you want to learn more! nature.com/articles/s4158… (/end)

@PageLabXY @NatureGenet @BeckyEAndersen @ChrisAWalsh1 ... from research about the male bias of autism, which is driven not only by the FPE but likely by a lot of other factors, including underdiagnosis of women & girls with autism & sex diff in the brain (14/n)

Autism has a significant sex bias, with roughly four boys diagnosed for every girl. New research from the Page Lab offers a genetic explanation for this disparity—one that may also extend to 17 other pediatric conditions that show similar sex biases: tinyurl.com/yzfvkpj4