Mudgeon of Cur

@AnaKrivolapova Are you in perimenopause?

I have poison ivy inside my ear canal

i remember a case similar to this from my time as a lawyer during a salvia trip

@equine__dentist Victor, the Lesbian

the victory lesbian

Saint Symeon the New Theologian, Divine Hymns of Love

@michelleefang Twitter, never show me this again

it’s THE spoon of silicon valley

@KeanuNazari @haravayin_hogh Interesting that some of them are in English! Did Chinese people know English during this era?

I got thousands of rare Cultural Revolution-era photos from a historical archive here in China. I believe some of these have never been posted online, or only exist behind extremely expensive licenses. So here they are, for free. Open the thread for more.

Read this as Christianity and Bartholin's Cysts. Cornelius, keep your blaspheming to yourself

@dusty_bumps Where your email finds me, in my merkaba orgone construct, bro

World peace

I want to live inside this aquamarine.

@kbala444 Intrauterine pregnancy!? What a comparison.

My favorite research genre is rigorous analysis of ridiculous people

@Outdoctrination Just added a gram of glycine powder to coffee and it made me so nauseous. This supplement is not for me.

The power of GLYCINE is seemingly never-ending. Let's get into the science, the incredible benefits & how to use it yourself: Glycine increases lifespan & promotes longevity in study (PMID: 30916479). ☆ Anti-inflammatory ☆ Controls gene expression ☆ Clears homocysteine (toxic) ☆ Supports glutathione production (antioxidant) ☆ Precursor to creatine (muscle + brain fuel) ☆ Collagen synthesis ☆ Promotes autophagy It counteracts the pro-aging effects of excess methionine, a major component of muscle meat. The combination of glycine + NAC is especially powerful for longevity as well. Combining them increases lifespan by ~25% in animal studies. They synergize to create the master antioxidant glutathione. ✓ Reduces organ damage ✓ Preserves mitochondrial function even at low amounts. Glycine + NAC is an anti-aging, metabolic elixir. ➜ Reduces oxidative stress ➜ Improves mitochondrial function ➜ Improves cognitive function ➜ Reverses insulin resistance Nearly every metric of aging and disease imaginable in a recent clinical trial. Glycine + NAC reverses aging, even in small amounts. Decline in energy production & increased oxidative stress are two of the hallmarks of aging, but this combination: ◇ Restores glutathione ◇ Improves mitochondrial fat oxidation ◇ Reduces body fat ◇ Reduces liver fat ◇ Lowers blood sugar ◇ Lowers insulin @ roughly half a gram of each daily (human equivalent) in other experiments. Part of the reason glycine has so many benefits because it is a universal anti-inflammatory. Suppresses the master regulator of inflammation - a gene regulator called NF-κB. This is upregulated in, I kid you not, every condition of aging + disease imaginable. Glycine also helps heal the gut. Endotoxin (LPS) is probably the primary cause behind most gut issues - leaky gut, bloating, pain, poor bowel habits, etc. Glycine reverses the damage that it does, lowering key inflammatory mediators in experiments including: ➜ TLR4 ➜ IL-6 ➜ IL-1β ➜ MYD88 ➜ TNFα See this all the time with our clients - it's often helpful for digestion and things like acid reflux. Glycine has been shown to prevent leaky gut. Glycine upregulates the tight junction proteins via activation of mTORC-1. By nourishing glutathione synthesis, it also supports the antioxidant system and prevents endoplasmic reticulum stress. This process is present in all digestive disorders. Glycine reverses liver damage, even from alcohol, in animal experiments. Alcohol drives liver fat buildup and damage, and can even contribute to scarring, but glycine: ⇨ Accelerates recovery of liver structure ⇨ Sheds liver fat since it acts as a calming agent for the liver's resident immune cells. Glycine can also protect your eyesight. Two of the primary mediators of long term damage to vision are: ⇨ Oxidative stress ⇨ Glycation (from high blood sugar) Glycine actually directly prevents both of these processes, saving the Müller cells which are vital for clear vision in studies. Glycine is a powerful sleep enhancer. 3g of glycine before bed: ⬩Increases subjective sleep quality ⬩Decreases time to fall asleep ⬩Increases cognitive performance the next day ⬩Makes falling asleep easier ⬩Lessened daytime sleepiness in part due to glycine's ability to help regulate the circadian rhythm in the brain. Because of this, glycine prevents tiredness & improves mental performance. 3 grams before a night of poor sleep. ➔ Inhibitory neurotransmitter ➔ Regulates circadian rhythm ➔ Lowers nighttime body temperature ➔ Increases blood flow One of the best supplements for sleep & cognition. If you can't stay asleep (or wake up to pee), you need to try glycine. 3g before bed in other studies has been shown to reduce: ⬩Night time urination ⬩Urination urgency ⬩Blood pressure Glycine is an inhibitory neurotransmitter that keeps us in restful sleep. Glycine is a powerful protective agent for your brain. It markedly improved stroke outcomes in one trial. 1-2g of glycine in people: • Reduced death • Substantially improved disability status in survivors by supporting antioxidant status & due to its anti-inflammatory prowess. In fact, glycine has been shown to improve mood & dopamine functioning, preventing: ⇨ Blunted affect (reduced emotional expression) ⇨ Alogia (poverty of speech) ⇨ Anhedonia (inability to feel pleasure) ⇨ Avolition (lack of motivation) Glycine can help prevent allergies in experiments. Animals fed glycine REDUCED: • Antibody production • Gut inflammation • Mast cell activation • Allergic symptoms Glycine interacts with various immune cells, "calming" their reactions and lowering inflammation. Glycine almost completely prevents kidney stones. People with kidney stones have LOW glycine, & glycine prevents kidney stones by: • Promoting citrate excretion, which binds excess calcium, preventing crystallization • Decreasing oxalate excretion Glycine has been shown to improve cold + flu by over 80% in some studies. 10 grams per day. Glycine supports the extracellular matrix (collagen), which provides a physical barrier to infections. Glycine is also an anti-inflammatory - aiding in recovery from illness. Glycine prevents weakening of bones with age, even in low amounts, in animal models. Glycine can increase: • Bone mineral density • Trabecular number • Connectivity density through increasing proliferation of osteoblasts, cells that help restructure bone. Even in a puny amount (<1 gram human equivalent). Anywhere from 3-5g, before bed, is what we do, but you can go up to 15 or 20g depending on your use case. Some people do react poorly to it, but those cases are very rare in my experience.

I don't think I have it in me to do a deep dive on megalithic dolmens till 2 am

Them's the rules and that's that

@Kohls your stupid iOS site blew up my phone

Yo trabajando en un artículo con 37 PDFs abiertos.

@JaycelAdkins Love this

Okay, this cover slaps!

Nothing pleases me quite like a website that looks like this. Scrumptious!