Medscape

Once weekly semaglutide injections reduced alcohol consumption in patients with alcohol use disorder and comorbid obesity. Results of the randomized controlled trial, the first, to the authors’ knowledge, to evaluate the GLP-1 receptor agonist semaglutide in patients seeking treatment for AUD who had comorbid obesity, also showed significant effects on multiple alcohol-related outcomes. AUD is a chronic brain disorder characterized by impaired control over drinking and compulsive alcohol use. Despite decades of research, only three medications — disulfiram, acamprosate, and naltrexone — have been approved by the FDA for AUD, underscoring the urgent need for more effective treatments. Tap the link to read more about the study. medscape.com/viewarticle/gl…

In patients with inflammatory bowel disease (IBD), handgrip strength — a simple, noninvasive measure of muscle function — showed a modest inverse association with clinical disease activity, particularly in Crohn’s disease; a positive correlation with health-related quality of life; and a negative correlation with depressive symptoms. mdsc.pe/4tPgvRb

Analysis of gut microbes can reveal whether a person faces an elevated risk of Parkinson’s disease before they have developed any clinical symptoms. Researchers found that people with Parkinson’s and healthy individuals at genetic risk of the disease share a distinctive makeup of gut microbes, strengthening the evidence for a link between gut health and neurodegeneration. mdsc.pe/4tgAgAe

Medics were working on Monday to evacuate two people with symptoms of the deadly hantavirus after a suspected outbreak on a luxury cruise ship held off West Africa carrying mostly British, American and Spanish passengers, ⁠officials said. Around 150 people were still stuck on the vessel after three people - a Dutch couple and a German national - died, and others fell ill, including a Briton who left the vessel earlier and was being treated in South Africa, authorities added. Hantavirus, which can cause fatal respiratory illness, is spread when droppings and urine ‌of rodents become airborne. There are no specific drugs to ​treat hantavirus, so treatment focuses on supportive care, including putting patients on ventilators in severe cases. Tap the link to read more. mdsc.pe/42hYI9d

Cannabis use among teenagers is linked to delayed cognitive development and worse memory over time, the largest US study to date showed. In an analysis of over 11,000 teenagers, cannabis use was associated with reduced improvement in memory, attention, language, and processing speed, compared to adolescents who did not use cannabis. When researchers zeroed in on specific cannabis components, they found that those who used tetrahydrocannabinol (THC) showed worse memory as they grew older, compared to nonusers. mdsc.pe/42cOas4

Asma Khalil, MD, was 3700 miles from Washington, DC, when her patients at a London hospital began asking questions about a White House press conference. Days earlier, on September 22, President Donald Trump had stood beside Health and Human Services Secretary Robert F. Kennedy, Jr., and proclaimed that using acetaminophen during pregnancy is associated with a “very increased” risk for autism. The news swiftly spread around the globe, prompting frightened moms-to-be to let their pain and fever go untreated. Others arrived at Khalil’s clinic fraught with guilt that they’d harmed their unborn child. Khalil set out to look into the data, leading an international team of scientists who — on top of running labs, teaching, seeing patients, and raising families — made time to scour the literature. In January, they published a sweeping review of 43 studies, finding “no clinically important” link between autism and acetaminophen use in pregnancy. Khalil is part of a growing movement of physician-scientists leveraging their resources and expertise to push back against what they view as an unprecedented wave of health misinformation. Read more about their efforts by tapping the link: medscape.com/viewarticle/un…

Dr. Nina Lum shares her top takeaways from her Pediatric Advanced Life Support renewal.

Watch LIVE tomorrow ➡️ youtube.com/watch?v=AuQl-6… Refine your approach to Hyperphosphatemia. Experts Glenn Chertow and Ellie Kelepouris share case-based insights on patient selection and novel therapies in DD-CKD. Tune in at 4pm! #Nephrology #CKD #CME

More than three quarters of US adults aged 40-75 years without known atherosclerotic cardiovascular disease (ASCVD) have one or more risk-enhancing factors. The presence of risk-enhancing factors was associated with increased odds of statin use, although this association varied across categories of ASCVD risk and was strongest in high-risk individuals. mdsc.pe/4tdvrYr

Hepatitis Awareness Month! Hepatitis is a “silent killer” causing liver damage and cancer. Screen asymptomatic patients, vaccinate for Hep B, and link positives to care. Prioritize prevention and education. ▶️ mdsc.pe/4724JJZ

🧠 Could you be missing AHP? Strengthen recognition of symptoms, refine lab testing, and better understand patient impact. Apply shared decision-making to optimize management. 👉 Diagnose earlier. Treat smarter! twitter.com/i/broadcasts/1…

Arab Med Schools With Standout Education mdsc.pe/4uqVEUn

🎯 Treating IBD isn’t just about symptoms—it’s about strategy 📊 Accurately assess disease severity 💊 Select therapies based on current evidence 🔄 Adjust treatment using a treat-to-target approach 👉 Level up your IBD management twitter.com/i/broadcasts/1…

Published in late 2025 in the journal Nature, a study of nearly 35,000 people represents a major step up in scale for human microbiome research: It identified and ranked gut bacterial species — both previously known and uncharacterized — that are associated with BMI, clinical health status, and dietary patterns. To better understand how the gut microbiome is linked to diet and metabolic health, the researchers developed a score that ranks bacteria according to their association with good or poor health. They also carried out dietary interventions to examine their impact on bacterial profiles. mdsc.pe/42o1JoF

Gabapentinoids like gabapentin and pregabalin are associated with an increased risk for poisoning, with the highest risk occurring around treatment initiation and when combined with benzodiazepines or opioids. In a large UK study of nearly 17,000 primary care patients, those who had co-initiation of gabapentinoids and benzodiazepines showed double the risk for hospitalization due to drug poisoning within the first month, whereas those with concomitant opioid use showed a 30% increased risk compared with those who took neither medication. mdsc.pe/4w6yUdZ

GLP-1 overdoses have been skyrocketing, with poison centers seeing a nearly 1500% increase in calls related to overdose or side effects of injectable weight-loss drugs since 2019, according to US National Poison Data Center. Experts suggest that the use of compounded drugs has exacerbated the overdose problem. However, increased utilization of GLP-1s and lack of patient education are also among the contributing factors. mdsc.pe/42GKVcg

A nightmare ER shift — and a little anger — led this doctor into a world of decision science, triage heuristics, and building a video game that makes doctors better. Tap the link to read more: mdsc.pe/4t8DTYX

Is It PPI-Resistant Erosive Esophagitis? x.com/i/broadcasts/1…

Starting in 1 HOUR ➡️ youtube.com/watch?v=HfbuNI… PPI therapy is evolving. Join our live social event to explore practical tips for erosive esophagitis care and shifting treatment paradigms. Not to be missed! #GERD #Gastroenterology #CME

"You’re exhausted. Sure, it’s not bedtime yet, but you know if you could just lay back and close your eyes for 30 minutes, an hour, everything would be so much better. The nap. Can’t be beat, right? Well, wrong, at least according to new research which suggests that daytime napping is a risk factor for death." Dr F Perry Wilson comments on a study that linked napping habits with mortality for older adults: mdsc.pe/4mZjcgu