Jess
55.2K posts

Jess
@MeetJess
Lover of all animals. Nature admirer. Elderly advocate. Bookworm. Sarcastic & compassionate. Music lover. Fierce Mama bear. #WeNotMe #COVIDISAIRBORNE














Human brain matters: Navigating the neuropathology of COVID-19 🚨COVID doesn’t just “inflame” your brain, it SCARS it PERMANENTLY. You don't want to read this study! #L0ngC0vid ➡️This landmark narrative review from the Netherlands synthesizes neuropathological findings from 352 postmortem human COVID-19 brains alongside biofluid and neuroimaging data from post-acute sequelae of COVID-19 (PASC/long COVID) patients, • Severe COVID-19 consistently shows vascular dysregulation and fluid-brain barrier disruption, including endothelial inflammation, microhemorrhages, and hypoxic-ischemic injury, • Chronic neuroinflammation (astrogliosis, microglial nodules, adaptive immune-cell infiltration) affects the olfactory bulb, medulla, midbrain, and cerebellum, • Neuronal damage occurs in the hippocampus, midbrain, and cerebellum, with protein aggregates appearing in the midbrain and entorhinal cortex, • Neuropathological burden and elevated biomarkers (IL-6, neurofilament light chain/NfL) directly correlate with clinical severity: anosmia, memory deficits, and cerebellar ataxia, • Elderly patients and those with pre-existing neurological disease are markedly more vulnerable, • In PASC, biofluid proteomics reveal persistent elevation of neuronal proteins and pro-inflammatory cytokines, indicating ongoing CNS injury long after acute infection, • Limitations well mentioned, also asking for a broader confirmation. ➡️Study fills a critical evidence gap: early pandemic reports were scattered, small-scale, and focused only on acute changes. This paper unifies the data to map acute vascular/fluid-barrier damage and chronic neuroinflammation PERSISTING into long COVID. ➡️This study proves COVID scars the brain after ONE-hit, but the science is already clear elsewhere: each reinfection stacks the damage higher. ➡️The authors conclude that vascular/fluid-barrier abnormalities, chronic neuroinflammation, axonal damage, and protein aggregation are the dominant mechanisms driving neurological symptoms. ‼️COVID-19 does not merely inflame the brain, it scars it permanently, seeding neurodegeneration that may haunt millions of survivors for the rest of their lives!!!!! #AvoidSars2 #AvoidReinfections #LongCOVID #NeuroCOVID onlinelibrary.wiley.com/doi/10.1111/bp…









