Jaroslawna Meister

Development of Mutant M3 Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins | Biochemistry pubs.acs.org/doi/10.1021/ac…

Hello Houston! @ASNKidney #KidneyWk #DKD #CKM

See you in Houston! 😊

Hamburg News: ⁦@PuellesVictor⁩ and collaborators push tissue analytics to the next frontier. This also marks a remarkable academic path: from postdoc to junior professor in our group to full professor at ⁦@UKEHamburg⁩ & ⁦@AarhusUni⁩ ⁦@Nature⁩ nature.com/articles/s4158…

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics | Nature Metabolism nature.com/articles/s4225…

In mitochondria, respiratory supercomplexes (blue) pump protons across crista membranes to create an electrochemical gradient, fueling adenosine triphosphate (ATP) synthase (pink) to regenerate ATP—the energy currency of life. Now, cryo–electron tomography captures these supercomplexes in their native organization, illuminating how the coordinated action of these molecular machines drives life’s fundamental energy conversion. Learn more this week in Science: scim.ag/3FQ6bEh

Happy International Women’s Day! We’re celebrating women who have changed the world. Here are all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award. Tell us about the women who inspire you the most - and why #InternationalWomensDay

Fyrma: Manage your business right from WhatsApp producthunt.com/posts/fyrma via @producthunt

CNTF regulates blood pressure by modulating AngII-induced pressor response @ ahajournals.org/doi/10.1161/HY… @HyperAHA @HHU_de

Last week was a milestone for Fyrma as I had the pleasure of pitching and demoing at the GigaParty in SF. The support and openness I encountered were truly inspiring, and it was amazing to see people getting started with Fyrma right away. The network effect is strong here!

@CoCo_Headley 2 on my desk with extended deadline and had to decline another 3 today…🌊📑

These journals asking me to submit a peer review today....dawg...read the room 💀💀

Please do not hesitate in posting more questions tagged with #HYPHIP! @MeisterResearch will be happy to respond. Thanks for participating in our #HYPHIP Live Twitter chat today! See you all in the next one! @HyperAHA

@Carmendemigue12 @HyperAHA @HHU_de @DiabResearch And thank you for the opportunity to discuss our work at the @HyperAHA X platform!

@Carmendemigue12 @HyperAHA @HHU_de @DiabResearch Thank you for your great questions, @Carmendemigue12! Awesome, to see the interest in our study! @HyperAHA #HYPHIP

What a fantastic chat today! We are now concluding our live #HYPHIP chat. Please join me in thanking @MeisterResearch and the @HyperAHA #SoMe team and community for a terrific chat! @MeisterResearch we are looking forward to your next paper! @HHU_de @DiabResearch

@Carmendemigue12 @HyperAHA A13/2: In addition, we want to uncover how salt causes epigenetic changes in the vessel, which are currently described as a salt memory. We are also interested in the influence of salt on neutrophil function, which played a role in our study. #HYPHIP @HyperAHA @carmendemigue12

@Carmendemigue12 @HyperAHA A13/1: We are currently focusing on the direct effects of salt on the endothelium, including its impact on energy balance and endothelial function. #HYPHIP @HyperAHA @carmendemigue12

Q13. Based on your exciting findings, what will your next studies focus on? #HYPHIP @HyperAHA @MeisterResearch

@Carmendemigue12 @HyperAHA A12/2: Therefore, in addition to a consistent reduction in blood pressure and lipid control, a reduction in salt intake would also be a promising approach that should be tested in clinical trials. #HYPHIP @HyperAHA @carmendemigue12

@Carmendemigue12 @HyperAHA A12/1: 1st, we need to translate our findings into clinical research. We know that inflammation plays a role in the development and progression of AAA and AAD. #HYPHIP @HyperAHA @carmendemigue12

Q12. How do you envision your findings changing the clinical approach to AAA/AAD? #HYPHIP @HyperAHA @MeisterResearch

@Carmendemigue12 @HyperAHA Yes. Most definitely! That's why salt intake could affect male and female individuals differently. #HYPHIP @HyperAHA @carmendemigue12

@MeisterResearch @HyperAHA But could females be more protected maybe because of different immune pathways being activated, perhaps anti-inflammatory? #HYPHIP @HyperAHA @MeisterResearch

Q10. You used only male mice in these studies. Was there a reason for this? Given the known sex differences in inflammation in hypertension and on high salt, would you expect similar effects in females? #HYPHIP @HyperAHA @MeisterResearch

@Carmendemigue12 @HyperAHA A11/2: There are probably different effects by drinking vs. eating since the reabsorption site in the gut may be different. #HYPHIP @HyperAHA @carmendemigue12

@Carmendemigue12 @HyperAHA A11/1: Even though this was not the focus of our study, we believe that the changes in the immune cell signature could be due to an effect of salt on the microbiome. #HYPHIP @HyperAHA @carmendemigue12

Q11. High salt has been shown to affect gut microbiota and their products. Do you think that some of the effects in your studies are driven by these changes in microbiota? Does drinking vs. eating highs salt change microbiota differently? #HYPHIP @HyperAHA @MeisterResearch