Melissa Hardy

The win ratio method was applied post-hoc to outcomes observed in the MERINO trial with a hierarchical composite endpoint of all-cause mortality, microbiological relapse and secondary infection

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@BradSpellberg @drpeterlange criteria.blood.gov.au/CheckEligibili…

@drpeterlange Right. Does all ITP qualify? Do you have to fail steroids first? Are there selection criteria?

Hi Med Twitter, lab test stewardship question for y'all. Has anyone found methods or techniques to better steward use of IV albumin and IVIG at your hospital? Appreciate any advice!

🦠 Our new paper highlights cost and access barriers to antifungals in Vietnam. Annual drug costs for major IFIs are $209.1M, so it’s vital to get these right. 👇🏻 ✅ Cost-effective procurement 💵 ✅ antifungal stewardship 💊 academic.oup.com/mmy/article/63… #AMS #mycology @Sydney_ID

Read the latest article from Professor Dame Sally Davies (UK Special Envoy on AMR) and Nikolaj Gilbert (President & CEO of PATH). There is a looming antibiotic emergency, and the time for global action is now: telegraph.co.uk/global-health/…

Exciting news! 🎉 NUS launches its Master's in Infectious Disease Emergencies in July/Aug 2025. Tailored coursework, hybrid learning, and networking opportunities await! Make an impact! 🌍💼 Register here👉forms.office.com/pages/response… #InfectiousDiseases #NUS

Whilst functionality and interpretation of both approaches differ, the use of a rank-based composite endpoint can provide more insights into treatment effect than a single binary endpoint i.e. mortality cmi-comms.com/article/S2950-… @davidantibiotic @padstamundo #UQCCR @MerinoTrial

We demonstrated and compared the DOOR and GPC approaches with a post hoc analysis of the MERINO 🐑trial. We highlight the advantages, challenges and potential application in antimicrobial trials. 5/6

Curious 🤔about how rank-based composite endpoints i.e. Desirability Of Outcome Ranking (DOOR) and Generalised pairwise comparison (GPC) compare in antimicrobial clinical trials? 1/6 🧵

🌍💡 Join us to design the next version of ACORN2 and ACORN-HAI by taking a 3-minute survey!! Have your say by end of October. Your input is invaluable! 🛑🦠💊 #AMR #AntimicrobialResistance #HealthcareInnovation 💻📊 👉 nus.syd1.qualtrics.com/jfe/form/SV_8b…

🆕️⚡️⚡️Exploring desirability of outcome ranking & generalised pairwise comparisons as endpoints in serious infections: Post hoc application/MERINO The application of DOOR & GPC approaches in this post hoc demonstrated superiority of mero over pip tazo sciencedirect.com/science/articl…

Win Ratio Analyses of Piperacillin-Tazobactam Versus Meropenem for Ceftriaxone-Nonsusceptible Escherichia coli or Klebsiella pneumoniae Bloodstream Infections: Post Hoc Insights From the MERINO Trial bit.ly/3RKNEwq

@MGilchrist123 @b_fekade @BSACandJAC @jasonroberts_pk @CRE_RESPOND @raseaton66 Well done @b_fekade

Lovely to meet my collaborator and long distance colleague again @b_fekade working to raise the bar re: opat stability of antimicrobials. Such a great partnership between 🇬🇧 and 🇦🇺 @BSACandJAC @jasonroberts_pk @CRE_RESPOND @raseaton66

@MGilchrist123 @b_fekade @jasonroberts_pk @raseaton66 @jamiesonce Congrats @b_fekade, @jasonroberts_pk and team. So amazing to see this finally published.

Great to see this - Evaluation of stability of ceftazidime/avibactam in elastomeric infusion devices used for OPAT. 🇬🇧 & 🇦🇺 partnership in this space continues ⁦⁦@b_fekade⁩ ⁦@jasonroberts_pk⁩ ⁦@raseaton66⁩ ⁦@jamiesonce⁩ & more academic.oup.com/jacamr/article…

AMR challenges RCT's which are critical to provide evidence in clinical decision making. We applied the win ratio method post hoc to the MERINO trial to provide more evidence and insights in ID trials. youtu.be/4UnG48cKVkY @davidantibiotic @padstamundo @InfectiousMoYin

Very privileged to be a part of “Making Waves” which will air on @SBSVICELAND in celebration of International Women’s Day, friday 8th March, 9.25pm sbs.com.au/whats-on/artic…

Win ratio analyses of piperacillin-tazobactam versus meropenem for ceftriaxone non-susceptible Escherichia coli or Klebsiella pneumoniae bloodstream infections: Post-hoc insights from the MERINO trial ✅ Just Accepted 🔗 bit.ly/3uloUm4