New from my lab: Ancestral sequence reconstruction analysis indicates the furin-cleavage-site insertion in the SARS-CoV-2 spike gene likely interrupted a codon academic.oup.com/ve/article/12/…
English
Meru Sadhu
135 posts
Meru Sadhu
@MeruSadhu
Investigator with the National Human Genome Research Institute, in the NIH. Views are my own.
Bethesda, MD Katılım Ocak 2016
130 Takip Edilen355 Takipçiler
Meru Sadhu retweetledi
New paper in #G3journal from @mongemmmm, @MeruSadhu, and colleagues presents a barcode-based high-throughput method that can track large numbers of independent replicates of a small number of combinatorial genotypes. buff.ly/Q0qgBQz
English
I’m really rooting for this approach to catch on! Of the papers I’ve been involved in, this is probably the one I most feel is contributing a different way of thinking. Big shoutout to the co-first authors, Molly Monge (now an MD/PhD student at Cornell) and Simone Giovanetti.
English
“High throughput” doesn’t have to mean hard/expensive! At its heart, the difference is that instead of picking a few clones of your transformation, you take all the colonies. And with low sequencing costs and the possibility of pooling sequencing, it will generally be affordable.
English
New paper from my lab! We describe our idea that high-throughput pooled experimental methods – typically used to test thousands of hypotheses at once – also have huge potential to help in “everyday” experiments testing one or a few focused hypotheses. doi.org/10.1093/g3jour…
English
New preprint from the lab: A maternal-effect toxin-antidote element causes larval arrest in C. elegans, by @sdraljefainc et al. biorxiv.org/content/10.110…
English
@leonidkruglyak @sdraljefainc Cool!!!
If the toxin is inactivated by unlinked genes in N2, then why does it exist? It won't drive. Maybe it provides viral defense, like various bacterial TA systems? (Apologies if the answer is in the paper; jumping the gun and asking questions from reading the abstract.)
English
Meru Sadhu retweetledi
Our obsession with yeast killer toxins was triggered by a collaboration with @MeruSadhu.
Now with @BPSIYork we have a PhD project to delve deeper into toxin effects (and defences) at the biophysical level.
Great opportunity for diverse skillsets. Apply:
tinyurl.com/y877rj3b
English
@arburga @IMBA_Vienna @oeaw @ERC_Research I'm late to see this, but it blew my mind when I did. Congrats!!!
English
Thank you to my amazing lab members & colleagues, and the support from @IMBA_Vienna @oeaw @ERC_Research for making our science possible. This is why we love curiosity-driven science. From time to time, we are fortunate enough to peek into the unknown and not return empty handed
IMBA imbavienna.bsky.social@IMBA_Vienna
‼️ Breakthrough in evolutionary genetics ‼️ #Virus-like #transposons wage war on the species barrier 🧬🦠🪱🐠🪼 An all-IMBA paper #JustPublished in @ScienceMagazine Read more ➡️ bit.ly/MavericksHGT IMBA's Burga Lab @arburga with co-first authors @SonyaWiden & @CampoBes nail down a vector of #HorizontalGeneTransfer (#HGT) in eukaryotes: The "culprits" are called #Mavericks - Ancient virus-like transposable elements @viennabiocenter @TrainingVbc @oeaw Link to the paper in Science ➡️ doi.org/10.1126/scienc… More on the Burga Lab's research ➡️ oeaw.ac.at/imba/research/… Congratulations to all authors: Sonya Widen, Israel Campo Bes, Alevtina Koreshova, Pinelopi Pliota, Daniel Krogull & Alejandro Burga on this groundbreaking work 🎉🎊
English
@MudabirAbdullah @GeneticsGSA And belated congratulations on the MERGE paper as well!
English
Happy to share my last thesis chapter is now out in @GeneticsGSA
Aashiq Kachroo@Aashiq_Kachroo
Check out the latest research from our lab @Kachroo_Lab published in @GeneticsJournal, shedding light on the unique protein-protein interactions governing the humanization of the 20S proteasome in yeast #humanizedyeast academic.oup.com/genetics/artic…
English
Now out in Genome Research! "Highly complete long-read genomes reveal pangenomic variation underlying yeast phenotypic diversity" genome.cshlp.org/content/33/5/7…
English
@greenkidneybean @JoshSBloom And thanks to Genome Research @genomeresearch and the anonymous reviewers - the entire process was very helpful and improved the manuscript substantially!
English
Thanks again to Team Genome: Cory A. Weller, Ilya Andreev, Michael Chambers (@greenkidneybean), Morgan Park, Josh Bloom (@joshsbloom), and the NIH Intramural Sequencing Center
English
Lab news: Postbac Molly Monge is headed to Weill Cornell’s MD PhD program @TriIMDPhD! Congrats, Molly and Cornell!
English
Complete story that taught me some cool biology. Congrats to all authors
Meru Sadhu@MeruSadhu
Wooo, first paper from the lab! We discovered a yeast defense factor against the killer toxin K28: a previously uncharacterized gene we named KTD1. Check it out! Open access on PNAS: pnas.org/doi/10.1073/pn…
English