Nature Reviews Methods Primers

This #PrimeView highlights the workflow for GPCR peptide discovery from biodiversity-derived sequences, structural data and peptide libraries. nature.com/articles/s4358…

Recent advances in #peptide-GPCR interactions are transforming drug discovery. This #Primer details experimental and computational approaches, from in silico peptide mining to modern biosensor assays, paving the way for novel therapeutics. nature.com/articles/s4358…

The #PrimeView features applications of distributional regression in health, ecology, and environmental science. nature.com/articles/s4358…

Explore how generalized additive models for location, scale, and shape (GAMLSS) extend traditional regression by modeling mean, variance, and more. This #Primer highlights the role of distributional regression in risk assessment and predicting uncertainty. nature.com/articles/s4358…

And choose your ideal polymer in the #PrimeView here: nature.com/articles/s4358…

Conductive polymers (CPs) have unique optoelectronic properties and mechanical ductility. This Primer discusses how these features make CPs suitable for next-gen optoelectronic and bioelectronic devices. nature.com/articles/s4358…

This #PrimeView highlights the standardized reporting procedures required when publishing results of laser cooling experiments. nature.com/articles/s4358…

Solid-state laser cooling has emerged as a promising alternative to traditional cryogenic methods. Check out this #Primer outlining the experimental considerations for laser cooling, emphasizing materials, cooling metrics, and thermometry. nature.com/articles/s4358…

And this #PrimeView highlights the use of MALDI IMS in the untargeted mapping of various biomolecules to link their distribution to various cellular contexts. nature.com/articles/s4358…

Matrix-assisted laser desorption/ionization imaging mass spectrometry (#MALDI IMS) enables detailed molecular mapping at cellular resolution. Check out the various mass analyzers and instrumental configurations in this new #Primer 🗺️nature.com/articles/s4358…

This #PrimeView highlights the different applications afforded to cucurbituril macrocycles due to their molecular-scale recognition and binding selectivity. 🛟 nature.com/articles/s4358…

#Cucurbiturils are synthetic macrocycles that serve as molecular containers. This #Primer explores their synthesis and applications in chemical sensing, drug delivery, and more, highlighting their high binding affinity for hydrophobic cations. nature.com/articles/s4358…

And check out the #PrimeView emphasizing the importance of correct data analysis for data generated using enzyme-tethering approaches for in situ epigenomics. nature.com/articles/s4358…

In this #Primer, a variety of #enzyme-tethering techniques, such as DamID, ChIC, CUT&RUN, CUT&Tag, and RT&Tag are highlighted, emphasizing their suitability for single-cell and spatial applications in biological research. 🪢🧬 nature.com/articles/s4358…

And the associated #PrimeView highlights the fabrication of magnetic tunnel junctions to ensure correct function of the devices 🚗 nature.com/articles/s4358…

MgO-based magnetic tunnel junctions (MTJs) enhance spintronic applications through coherent spin-dependent tunnelling and significant tunnelling magnetoresistance. 🔄🧲Check out the #MTJ #Primer here: nature.com/articles/s4358…

From the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy, "It takes two combs to tango" eurekalert.org/news-releases/…

The #PrimeView highlights the experimental set-up on a laser table. 🪮🌈 nature.com/articles/s4358…

Explore the world of #dual-comb spectroscopy, where two optical frequency combs enable precise, rapid measurements without mechanical scanning. This #Primer covers its principles, performance, and future applications from terahertz to ultraviolet. nature.com/articles/s4358…

And check out the fun, associated #PrimeView, highlighting the experimental setup of a TA spectrometer 🏃‍♂️🏃🕵️ nature.com/articles/s4358…

Transient absorption (TA) spectroscopy offers a window into the dynamics of excited states in molecules and materials. This #Primer explores TA's role in tracking photoinduced processes with femtosecond precision. nature.com/articles/s4358…