Michele Schlich

RNAi therapeutics target disease at its roots rather than just treating symptoms. Based on Nobel Prize-winning science, these genetic medicines silence disease-causing genes before unwanted proteins are made. 5 key facts: bit.ly/4lJQmOP #RNAi #GeneticMedicine

We are happy to #release the announcement of the next @CRS_Italia workshop! Join us in sunny #Bari on May 15th-17th for intense days of science and networking. Discover this year's theme & invited speakers, and register at crsitalia.it/events/worksho… @CRSScience @CRS_YSC

After 9+ months of meetings and organisation, we finally gave birth to the Next Generation Chemists 2024 Conference! It was amazing!!! We are looking forward to meeting you at the next edition #NGC26 @UNICA *********** #NGC24 #SCI #SocietàChimicaItaliana #ChemistryIsEverywhere

An exciting Research Assistant position in the Zhou Lab on RNA drug development. here is the applicaiton link: ucl.ac.uk/work-at-ucl/se… Application deadline 20th Oct 2024. Please do help circulate it.

New piece on #microfluidics parameters for #liposome fabrication, with #moleculardynamics insights by @mpannuzz @AstraZeneca. Check it out to see how flow rate ratios and post-production dilution impact the encapsulation of lipophilic drugs💊. @univca sciencedirect.com/science/articl…

Happy faces of the full Italy chapter board at #CRS2024: an intense week of inspiring science and meeting opportunities with old and new friends. We are happy to have supported 35 young scientists with travel grants to take part in this brilliant event @CRSScience @CRS_YSC

In diretta dal #SimposioAFI @afiscientifica! Passate a trovarci per conoscere le nostre attività, tra cui l’iniziativa #ESTRUM dedicata ad università ed aziende

Hot off the press 🗞️: Polyphosphoester-stabilized cubosomes encapsulating a Ru(II) complex for the photodynamic treatment of lung adenocarcinoma. A truly collaborative effort! 💡🧫@LucaConti_Chem @MarcoFornasier @FrederikWurm #sergiomurgia #claudiagiorgi sciencedirect.com/science/articl…

FDA Approved the First CRISPR Treatment – Potential Cure for People with Sickle Cell Disease ⬇️ oligotherapeutics.org/fda-approved-t… #ots #oligotherapeutics #scd #sicklecelldisease #fda #casgevy #lyfgenia #genetherapy #CRISPR #pharmaceuticals #medicine #currentresearch #science

Are you interested in organic synthesis? We have a post-doc position available in our mechanochemistry group. The position is based in a beautiful location in Cagliari. If you're interested, please send your CV to me privately. Take advantage of a one-of-a-kind opportunity!

Merry Christmas to all believers 🎄✨🎅🏼 #oldbutgold

@tlmoore_BioNano @DeptPharm_Unina @UninaIT @ClemsonBIOE @MerkleInstitute @AMIBioNano @iit Great news my friend, congratulazioni ! 🥂

Beyond thrilled to join the @DeptPharm_Unina @UninaIT as a tenure-track asst prof. Feeling humbled and grateful for the opportunities I had at @ClemsonBIOE, @MerkleInstitute @AMIBioNano and @IIT @MINDED_MSCA. Looking forward to jumping into some exciting science here in Napoli!

@MarcoFornasier @Fysiografen1772 Well deserved Marco, congrats!

Don't miss the next @CRSScience Local Chapter webinar next week (November 16, 2023): a targeted dose of #drugdelivery science provided by @CRS_GermanChapt 🇩🇪 and @CRS_Italia 🇮🇹. Link for registration: controlledreleasesociety.org/events/lc-webi…

Closing remarks from the president #stefanosalmaso and local chair #fabiopalumbo “As @CRS_Italia community, we are one branch of a big tree”. Thanks to all the attendees, the speakers and the sponsors, see you in Bologna #CRS2024! @CRSScience @CRS_YSC

It’s time for RNA & protein delivery session 🧬 Inspiring talks by #kevinbraeckmans @ugent on laser-based approaches to safely transfect cells, and @VArechavala on the importance of #delivery to traeat #rarediseases in difficult-to-reach tissues @AON_Delivery @CRS_FG_Gene

Very cool to see this previous project from Italy @IITalk @pgdecuzzi on the inside cover of @RSCApplied Polymers first issue! Article here: pubs.rsc.org/en/content/art…

Here are the top ten answers (for me) to the most important question we should ask ourselves everyday… a thread 🧵 #CRS2023 @CRSScience Retweet = follow! Please add your own thoughts and retweet! Thank you 🙏🏼

A mind-blowing paper has come out today in @Nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/sc…). Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome. The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution. Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell. When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part. The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival. The conclusion of the paper is metaphorically a quote from the Jurassic Park movie: “Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (scienmag.com/artificial-cel…) nature.com/articles/s4158…

Aaaaand it’s done! Over 120 plasma samples prepared for HPLC-MS to determine the PK of our liposomal adrenaline🐖💉. Simply not possible without the precious help of Alessio, super pre-doc trainee in our lab #REVIVEproject @univca @SardegnaRs