Luke Turner 🦠

Perfect pre-travel/holiday listening

@kakule06 🎉 Excellent answer!

@MicroLukas Oropouche virus; RNA virus in the Peribunyaviridae family, transmitted mainly by the biting midge Culicoides paraensis in tropical areas of South America and the Amazon basin and it causes Oropouche fever; an acute febrile illness characterized by fever, headache, myalgia.

Who am I?

@Betopaniz Bingo 🏆

@MicroLukas Oropouche

A 74-year-old man presented to the hospital for the third time in three weeks with recurrent fever, muscle aches, and vomiting. In the prior two hospitalizations, symptoms had self-resolved and broad work-up was unremarkable. He had traveled to Yosemite National Park one week prior to symptom onset. Physical examination was notable for rigors and diaphoresis. Peripheral blood smears are shown. What is the most likely diagnosis? nejm.org/image-challeng…

@sadiamir70 Yes 👍👍

@MicroLukas Nitrofurantoin

@dahmy44 🏆🏆 Bingo

@MicroLukas Nitrofurantoin👍🏻

@StephenTristram Spot on 😊

@MicroLukas Klebsiella pneumoniae has a chromosomally encoded narrow specrum B-lactamase, and as an example, a mutation of a G to an A causes the Gly238Ser amino acid substitution. This substitution alters to properties of the B-lactamase to an ESBL (enhanced hydrolytic capacity).

How can a single base pair mutation convert a standard Klebsiella pneumoniae into an ESBL producer?

So don't be too shocked next time you see an ESBL Klebsiella. It can easily happen without any help from plasmids or other transmission events. x.com/MicroLukas/sta…

This really highlights the need to screen for ESBLs using cefotaxime AND ceftazidime. eucast.org/fileadmin/src/…

An interesting one today.... firstline.org/microbial-purs…

【Staphylococcus lugdunensis】 Let's review the 5 key characteristics of S. lugdunensis that can lead to virulent infections! Level: Intermediate #IDMedEd #IDFellow #IMResident #MedStudent

@phlegmfighter Possibly....or is this more of a 'which pbps do they target' question 👀

@MicroLukas One of the other drugs lets it get inside

Quick quiz: If Enterococci are intrinsically resistant to cephalosporins (fig. 1), then why do we use it to treat enterococcal endocarditis (fig. 2)? 🤔🤔🤔

Great to see most people know the clinical signs of measles. The time lines, e.g. Incubation and infectious periods are tough ones to remember. Well done everyone 🥳