MikaelScience

Excited to share our Annual Reviews in Biophysics article on Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function. Many thanks to all authors for their diligence putting this summary overview together! pubmed.ncbi.nlm.nih.gov/39013028/

Out today from the Blanchard lab! An important paper showing that the accuracy of smFRET measurements depends on excitation strength, and how to correct for these issues or bypass them with self-healing dyes. nature.com/articles/s4159…

@IsraelF96135088 Nah, these Everest guys aren't stabbing each other to be the first to the top :)

CryoEM labs doing ribosomes!

@IsraelF96135088 Looking at fig. 3a, maybe you should be a little worried @IsraelF96135088 😂

All right, The End guys... Or may be not...

» Ribosome-binding antibiotics increase bacterial longevity and growth efficiency | PNAS pnas.org/doi/abs/10.107…

High resolution Molecular dynamics (MD) of mRNA translation on ribosome

It is out in @PNASNews. A massive bioinformatics undertaking by @gem__atkinson lab + an insane amount of experiments from my team and numerous collaborators. The first new phage defence system from Lund! @HenrikStrahl @arneelof @KarinErnits @FacultyLund pnas.org/doi/10.1073/pn…

Happy to share that Mathew Gagnon and my lab's joint story of translation inhibition by aminoglycoside Amikacin is now published in @NatureComms 🥳🥳🥳. Superhappy for this collaboration. Fast-kinetics biochemistry and structure together make a very powerful tool afterall 😃

Our study shows that ribosomal genes—widely used to infer the origin of species—also hold a record of the optimal growth conditions for a given species, making it easier to infer the optimal environment for uncultured or extinct organisms (1/3): academic.oup.com/nar/article/do…

check out our Spotlight Article @TrendsGenetics 🔥 hot 🔥 off the press! teamed up with @OlivierDuss (@EMBLHeidelberg) & @RainerNikolay (@MPI_MolGen) to cover the recent mRNA decoding ribosome smFRET🤝cryoEM story from @TheBlanchardLab open access 👇 authors.elsevier.com/a/1hJjvcQbJ7Wti

In our new Spotlight in @TrendsGenetics we are discussing the recent @Nature paper from @TheBlanchardLab about eukaryotic mRNA decoding combining smFRET and cryoEM! Was fun to collaborate with & @MatthewKraushar & @RainerNikolay @MPI_MolGen on this! sciencedirect.com/science/articl…

We suffered two problems on our Krios/Arctica instruments related to a pressure gauge called PPal. Here a picture of the faulty PPal from the Arctica. But then...what is a PPal and how it measures pressure? These two questions kept me busy for a while, a thread to follow 👇

Very soon and thanks to one an only @delarosatrevin an integrated solution for CryoEM facility management and on-the-fly processing with Cryolo/ctfffind/Relion ! And free!!! 👇🏽 Look at these gorgeous ribosome from @TheBlanchardLab !

Happy to anounce our paper published today ⁦@Nature⁩ - a tour-de-force in tRNA biology. We developed suppressor tRNAs with high efficieny in correcting PTCs. For a disease protein we crossed a disease threshold of correction. #cftr #uhh nature.com/articles/s4158…

Proud to be involved in this work. Please have a look. High res.80S ribosome, many states, interesting story. @TheBlanchardLab @AlexmagCryo @KundhavaiS nature.com/articles/s4158…

Is mRNA decoding in humans structurally and kinetically distinct from bacteria? news-medical.net/news/20230407/… @Nature @StJudeResearch #mRNA #bacteria #molecularbiology #research #bacteria #microbiology #cells #news

Mechanism of messenger-RNA decoding in humans illuminated nature.com/articles/d4158…

See also Research Briefing here: nature.com/articles/d4158… Congrats @TheBlanchardLab @MikaelScience @ERundlet @KundhavaiS and all authors!

Now #OA @Nature: combining #cryoEM and #smFRET to examine decoding by human #ribosome, @TheBlanchardLab reveals important differences from bacterial ribosome and mechanisms of action of several translation inhibitors. nature.com/articles/s4158…

Human ribosomes decode messenger RNA 10 times slower than bacterial ribosomes—but do so more accurately. Explore how St. Jude scientists made this discovery. bit.ly/3zxa9v8 @TheBlanchardLab @nature #cryoEM