Mildred Unti

So excited to announce that my most recent work has been published. If you’re interested in genetically encoding circular mRNA, or packaging circular mRNA into virus-like particles for cell-type specific delivery, this paper is for you!

@elliebenitez11 @Nature @andrewrmoorman @f_cambuli @KarunaMDPhD @dana_peer @nawy_t @TriIMDPhD @KarunaGaneshLab Huge congrats!

So excited to finally share our work out in @Nature today, exploring plasticity during metastatic progression in CRC! Huge thank you to @andrewrmoorman @f_cambuli @KarunaMDPhD @dana_peer @nawy_t for the wonderful collaboration and endless learning 👩🏽‍🔬 @TriIMDPhD @KarunaGaneshLab

Happy to announce that PERT is now published in @NatureComms ! With PERT, we explore replication timing variability (Fig 3-4), chrXi reactivation (Fig 5), and how S-phase fractions struggle to approximate clone fitness (Fig 6). nature.com/articles/s4146… 1/n

The future of genome editing is in vivo! Check out our latest @PNASNews perspective from @doudna_lab. Had a lot of fun discussions with @kevin_wasko and @JRo_Hamilton about the past, present, and future of in vivo delivery. pnas.org/doi/10.1073/pn…

Happy to see that my paper was a featured article in this special issue of Cell Chemical Biology featuring RNA. Go check out this awesome issue:

Do you want to know how much of your favourite m6A site is methylated? You can find out in *one day* using @AashiqHMirza's new method, SCARPET! Find out more about it here: doi.org/10.1261/rna.07…

Our lab's very own @shino_murakami will be giving a talk about the interplay between ribosomes, amino acids, and m6A at the @Tri_I_RNA mini symposium! Sign up to hear from her and other amazing RNA scientists here: buytickets.at/triirnaclub/10…

Weill Cornell and MSK friends, I will be participating in this years 3MT. Come by if you want to hear a fun 3 minute story on circular mRNAs in VLPs!

Interested in expressing your mRNAs for a longer time? Want to have cell-specific targeting AND prolonged protein expression? Check out how @MildredUnti achieved this with translating circular mRNAs! Congratulations Millie!

Online now! Highly efficient cellular expression of circular mRNA enables prolonged protein expression by Mildred J. Unti @MildredUnti, and Samie R. Jaffrey @JaffreyLab at @WeillCornell #resource dlvr.it/SxxYbc #chembiol

Our latest work by @michaelgeeson and @jeffreychsiao shows that NLRP1 associates with TRX1 using a transient disulfide bond. Their discovery showcases the predictive power of AlphaFold-Multimer! biorxiv.org/content/10.110…

I had a blast presenting my work at the @NYCRNASymposium. Overall a fantastic event with great science.

Come join us to hear our very own @MildredUnti talk about expressing proteins from circular mRNA, among other great speakers! Also, catch several of our graduate students and postdocs at the poster sessions!

Check it out!

Highly efficient cellular expression of circular mRNA enables prolonged protein expression biorxiv.org/cgi/content/sh… #bioRxiv

Furthermore, we show that the Tornado translation system can be used to package circular mRNAs into virus-like particles to achieve cell-type specific delivery of a circular mRNA.

We show that the Tornado translation system can be used for robust protein expression from a circular mRNA.

My latest work entitled “Highly efficient cellular expression of circular mRNA enables prolonged protein expression” is now on bioRxiv (1/n) biorxiv.org/content/10.110…

Registration and abstract submission for the 1st NYC RNA Symposium is open! Please spread the word!! nycrnasymposium.com @NYCRNASymposium #NYCRNASymposium