MODEL-AD

It is so important that we use the right models to understand disease. We are hoping to make those right models for #Alzheimers in the aim to #ENDALZ once and for all!

We are hiring!!! The UCI ModelAD team is seeking a highly motivated Database Research Specialist with expertise in data integration and metadata harmonization to support large scale animal model and genomics research efforts. Full position description: recruit.ap.uci.edu/JPF09537

At #AAIC24, MODEL-AD consortium showcases growing menagerie of mouse models that reflect different flavors of Alzheimer’s disease. @Model_ad_alz ow.ly/PWCT50TrewU

Check out what we’ve been doing lately… alzforum.org/news/conferenc…

@NeurosciStark @AlzIndiana @alzassociation @garethhowell10 too!

Thank you to all of the PIs who participated in Team Stark’s Pie the PI fundraiser! We raised $300 for the #Walk2EndAlz! @AlzIndiana @alzassociation

Stop by to chat about data, animal models, and more! #AAIC24 @Model_ad_alz @NIH

If you’re at #AAIC24, come by poster 16 today (Sunday) to learn more about the differential effects of the Apoe Christchurch variant on amyloid and tau pathology! @Model_ad_alz

📢 register now! Only a few seats left! jax.org/education-and-…

Check out the AlzPed webinar: An Open Science Tool Raising the Standards for Preclinical Testing of Candidate Therapeutics in Alzheimer’s Disease Animal Models   Date: April 30, 2024 Time: 12:00PM ET Registration link: us02web.zoom.us/webinar/regist…

And another paper alert from the UCI ModelAD center! This time is about the interesting ABCA7 variant!

Paper alert from the UCI ModelAD center! Go check it out if you are interested in genetic diversity!!!

A new publication as part of our 'Glial and Vascular Contributions to Neurodegenerative Diseases' review series! Check out this exciting series, written by well-known experts in the field, on our website bit.ly/3OFQ8Kg

'Comparison of immunoassay- with #massspectrometry-derived p-tau quantification for the detection of #AlzheimersDisease pathology' @JosephTherr @woo_marcel @gesalbla... @pedrorosaneto @MCSA_Montreal @mcgillu @lunduniversity #biomarkers bit.ly/47lSbdP

Scientists found 15 risk factors for young-onset #dementia. Many also correlate with late-onset disease. Addressing the 14 that are modifiable might prevent both. @MaastrichtU ow.ly/5Mgo50QopES

'Proteo-genomics of soluble #TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for #AlzheimersDisease' Lihua Wang & Niko-Petteri Nykänen... @ccrugom @Neuro_Genomics @WUSTLmed #microglia #APOE #Proteogenomics bit.ly/3vsSnug

Make sure to check this out! 👇 We are excited about it and hope you will be too #Alzheimers

Microglial AD risk gene INPP5D produces less functional protein in #alzheimersdisease brain, releasing the brakes on inflammation. @BrighamWomens ow.ly/S2Ji50QmjnB

The plasma Aβ42/40 ratio was three times lower in people taking the heart failure drug #Entresto than in people with brain amyloidosis. Entresto might confound #Alzheimersdisease blood test results. @goteborgsuni @UofGlasgow ow.ly/ayIw50QmjBX

A single-cell spatial transcriptomic and proteomic study of #immune cells in the human #CNS border compartments reveals differences in CNS-associated macrophages across age, perturbation and disease. @r_sankowski #macrophages #microglia nature.com/articles/s4159…

A kicks neural circuitry into overdrive, coaxing tau entanglement from afar. @UCBerkeleyNeuro @UON_research ow.ly/AqA050QlWw7

Check out our latest pre print in which we have assessed brain and serum metabolomes of mouse models and identified genotype, sex and tissue specific effects that mimics metabolomics changes observed in human AD @Model_ad_alz