Moldovan Lab

Sharing our latest review on single stranded DNA gaps and their impact on cancer chemotherapy outcomes portlandpress.com/biochemj/artic…

Sharing our new paper on the nuclease EXO1. We employed CRISPR genome-wide screening and identified an EXO1 pathway for R-loop suppression doi.org/10.1093/nar/gk…

Sharing our work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. nature.com/articles/s4146…

Thrilled to announce that Alexandra Nusawardhana, graduate student in the lab, was awarded an F31 National Research Service Award fellowship by @theNCI to investigate the role of EXO1 in genomic stability. Congratulations Lexi!

So happy and proud to hood Drs. Lindsey Pale, Jude Khatib and Josh Straka at the 2025 Penn State College of Medicine Commencement ceremony. Congratulations and all the best in your careers!

@CharlesMBrenner sorry about the typo :) I got carried away. I should start studying translation synthesis, perhaps the funding opportunities in that field are better...

@MoldovanLab translesion synthesis....

Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”. sciencedirect.com/science/articl…

Our year in pictures. Happy holidays everyone!

Congratulations Dr. Straka! Josh successfully defended his PhD thesis today. Wishing him all the best in his future career!

Happy to share our new publications in Nucleic Acids Research on the regulation of PRIMPOL doi.org/10.1093/nar/gk… doi.org/10.1093/nar/gk…

Check out our review on the impact of bisphenol A (BPA) on genomic stability academic.oup.com/narcancer/arti…

Congratulations Dr. Khatib! @JudeBKhatib successfully defended her PhD thesis today. Looking forward to her future accomplishments!

PS. Ashna is not yet done with genome stability: look out for her final paper from the lab coming out (hopefully) soon!

Bittersweet day, saying goodbye to Dr. Ashna Dhoonmoon who leaves the lab today after 5+ tremendous years with us. She was the heart and soul of the lab and we will miss her dearly. @Ashna_Dh All the best in your future career!

Happy to share our paper by @JudeBKhatib and @Ashna_Dh on the role of PARP10 in gap filling. rdcu.be/dOOCp

Grateful for the opportunity to present our work this week, and happy to see three other former graduate students of the late Stefan Jentsch on this list @PfanderLab @RapeLab @stingele_lab. This one is for you, Stefan!

The final lab selfie with @Lindsey_Pale as member of our group. Wishing her all the best as she transitions into the next phase of her career.

We attended our Departmental Annual Retreat. @anastasiamhale and @Ashna_Dh gave oral presentations and @JudeBKhatib won the best poster award. Congrats everyone! Stay tuned for their new stories coming out soon!

Congratulations Dr. Pale! @Lindsey_Pale successfully defended her PhD thesis.