Molecular Metabolism

𝗖𝗵𝗲𝗰𝗸 𝗼𝘂𝘁 𝗼𝘂𝗿 𝗔𝗽𝗿𝗶𝗹 𝗜𝘀𝘀𝘂𝗲! 🧘Cover Story: GIP signaling helps curb appetite while reducing the unwanted side effects of PYY - sciencedirect.com/science/articl… 🧘 Browse the full edition: molecularmetabolism.com

TRPC6 governs brown adipose #thermogenesis via a BMPR2–p38 MAPK signaling axis. BAT-specific TRPC6 loss impairs thermogenic signaling and exacerbates diet-induced #obesity and #metabolicdysfunction. 🔗sciencedirect.com/science/articl…

A new LC–MS/MS method captures key epigenetic metabolites (SCFAs, SAM, acetyl-CoA), advancing studies of metabolic control in #epigenetics. 🏛️@yaneslab @jmirobla @universitatURV 🔗sciencedirect.com/science/articl…

The primary cilium functions as a non-redundant signaling compartment essential for GLP-1R action in islet beta cells @MolMetab sciencedirect.com/science/articl…

Semaphorin 7A regulates axon outgrowth in subcutaneous #AdiposeTissue during #postnatal development. Loss of Sema7A disrupts adipose innervation and tissue architecture, highlighting a role for neural patterning in adipose organization. 🏛️@OSUWexMed 🔗sciencedirect.com/science/articl…

FGFR1 signaling in AgRP neurons regulates #EnergyHomeostasis under high-fat diet. Loss of FGFR1 increases neuronal activity and links #FGF21/α-Klotho signaling to central metabolic control. 🏛️@EastCarolina 🔗sciencedirect.com/science/articl…

Maternal #obesity shortens offspring lifespan and accelerates age-related #fibrosis in kidney, liver, and heart - even when offspring remain lean. 🔗sciencedirect.com/science/articl…

#ERK3 deletion promotes an oxidative shift in #skeletalmuscle, increasing mitochondrial function and oxidative capacity. These findings identify ERK3 as a regulator of muscle metabolic plasticity. 🏛️@PAN_akademia 🔗sciencedirect.com/science/articl…

Our collaborative study with Dr. Qiong Duan on histone acetylation regulated energy storage is now published @MolMetab. We established more understanding on how "active" acetylation vs "passive" acetylation balanced each other at different states. molecularmetabolism.com/article/33284/…

A new review explores the evolutionary roots of #insulinresistance and its interplay with the immune system. Understanding IR through evolutionary medicine may reshape how we view #metabolicdisease. 🔗sciencedirect.com/science/articl…

More chemogenetic evidence for the importance of murine PPGNTS+IRT neurons in the control of satiety, food intake and body weight @MolMetab sciencedirect.com/science/articl…

📢 Become a sponsor of the 13th Helmholtz Diabetes Conference! ✔ Secure your booth in our sponsor area ✔ Connect with international diabetes researchers ✔ Increase your visibility across website, program & app 🙌 Check out your options in our website: t1p.de/zegxf

𝗢𝘂𝗿 𝗠𝗮𝗿𝗰𝗵 𝗜𝘀𝘀𝘂𝗲 𝗶𝘀 𝗢𝗨𝗧 𝗡𝗢𝗪! 🍃 Cover Story: Maternal diet can program lasting metabolic changes in offspring, even if they remain lean as adults (t1p.de/jwo9a) 🍃 Browse the full edition: molecularmetabolism.com

🧬 Fibre type matters for #insulinresistance Glycolytic muscle accumulates C18 ceramides linked to lower #insulinsensitivity, while SGMS2 helps limit ceramide burden in oxidative muscle. 🏦 @umeauniversity 🔗 sciencedirect.com/science/articl…

Broadening the intersection of GIPR signaling with anorectic and aversive actions of PYY in mice @MolMetab sciencedirect.com/science/articl…

𝗖𝗵𝗲𝗰𝗸 𝗼𝘂𝘁 𝗼𝘂𝗿 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 𝗜𝘀𝘀𝘂𝗲! ❄️Cover Story: #Obesity limits #brownfat #thermogenesis by reshaping DNA methylation programs during cold exposure ❄️sciencedirect.com/science/articl… ❄️Browse the full edition: molecularmetabolism.com

🚀 We are live! The website for the 13th Helmholtz Diabetes Conference is now online! Explore the speaker list and key information on the meeting on 21–23 September! Program & registration coming soon. 👉 helmholtz-munich.de/en/diabetes-co… #SaveTheDate #StayTuned #HelmholtzDiabetes2026

Whole-body p21 transgenic🐭 #SkeletalMuscle atrophy fibrosis ⏬Treadmill Grip strength SkM transcriptomic #Senescence #SASP ⏬OXPHOS ⏫myonuclei & interstitial cell #DNADamage p21 overexpression does Not increase p16 in SkM @NKLeBRASSEUR @MolMetab 2023 sciencedirect.com/science/articl…

αMG stimulates endogenous glucagon secretion via SGLT1 in mice and may lead to a therapeutic strategy for #obesity associated metabolic diseases. sciencedirect.com/science/articl… @MolMetab

Dissecting the importance of the murine GCGR vs the GLP-1R for the CNS and #weightloss actions of survodutide @MolMetab sciencedirect.com/science/articl…