Jun Qi Lab

433 posts

Jun Qi Lab

@JunQiLab

Chemical Biology lab @HarvardMed and @DanaFarber. We use a multidisciplinary approach to study biological roles of epigenetic proteins & transcription factors.

Boston, MA Katılım Aralık 2018

423 Takip Edilen1.6K Takipçiler

Jun Qi Lab@JunQiLab·8 Tem

Thank you for featuring our collaborative work.

Science in Boston@ScienceinBoston

A new study from @DanaFarber reports the first potent and selective compound to target IRF4 and validates degradation of IRF4 as a potential approach to the treatment of #MultipleMyeloma. 🔎 See the abstract from Drs. @JunQiLab and @IrenemGhobrial: go.nature.com/4wq8rY0

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Jun Qi Lab@JunQiLab·29 Haz

We also like to thank @AlexsLemonade @StBaldricks @EpendymomaRF @sontagfdn @IronMattLarson @curingcancer @sontagfdn @TheVFoundation and more... for their support and helping us build the drug discovery capability for pediatric brain tumor.

Jun Qi Lab@JunQiLab

Thrilled to share our collaborative work with @FilbinMariella, now online in Neuro-Oncology! We identify HDAC2 as a tractable target for H3K27M DMG growth in vitro and in vivo. Congrats to @JunQiLab and @FilbinMariella — excited for more to come together! academic.oup.com/neuro-oncology…

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Jun Qi Lab@JunQiLab·29 Haz

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Jun Qi Lab@JunQiLab·5 Haz

Our study demonstrated that IRF4 can be chemically targeted. Our approach can be further developed into novel therapy for multiple myeloma. nature.com/articles/s4158… Please support our drug discovery effort for high risk tagets @JunQiLab at @DanaFarber. danafarber.jimmyfund.org/site/TR?team_i…

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Jun Qi Lab@JunQiLab·29 May

@10mM_Mike what a journey. Congratulations!

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Mike Agius@10mM_Mike·28 May

/1 Check out our new small molecule degrader of IRF4 💥 – dIRF2 – which is highly selective for IRF4 & induces strong myeloma cell killing! Degraders are a great fit for transcription factors that have well defined structures like the IRF-Family! nature.com/articles/s4158…

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Jun Qi Lab@JunQiLab·28 May

Our collaborative work with @IrenemGhobrial on targeting transcription factor IRF4 is now online @nchembio. It is so exciting that we discovered an IRF4 binder & a selective IRF4 degrader that can interrupt MM cell growth. Congrats @10mM_Mike & all authors rdcu.be/flcIs

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Jun Qi Lab@JunQiLab·9 Mar

@sciqst @MolMetab Yes, with the multiple targets and pathways we identified, they are all can be targets for novel therapy development.

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Raffaele Di Giacomo, PhD@sciqst·9 Mar

Congratulations on the publication, it's intriguing to see histone acetylation taking a central role in energy storage regulation. How do you think these insights might affect therapeutic approaches for metabolic disorders? Could this lead to potential biomarkers for disease states based on acetylation profiles? Both "active" and "passive" acetylation balancing mechanisms seem like an intricate dance, potentially opening novel avenues in epigenetic therapy. For more in-depth discussions and to explore further biomedical reviews, Sci-Quest offers an excellent platform at sciqst.com. #Epigenetics #Medicine

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Jun Qi Lab@JunQiLab·8 Mar

Our collaborative study with Dr. Qiong Duan on histone acetylation regulated energy storage is now published @MolMetab. We established more understanding on how "active" acetylation vs "passive" acetylation balanced each other at different states. molecularmetabolism.com/article/33284/…

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Jun Qi Lab@JunQiLab·25 Şub

Thank you @StBaldricks for highlight our research on studying natural compound in DMG with Prof. Movassaghi @ChemistryMIT and @FilbinMariella. Thank you so much for your support @StBaldricks

St. Baldrick's Foundation@StBaldricks

Hope is powerful. Research is lifesaving. 🙏 Your support helps fund groundbreaking discoveries for children battling cancer. Read how it’s making a difference in our latest edition of Research Outcomes: ow.ly/sNel50YhTUk

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Jun Qi Lab@JunQiLab·23 Oca

With better understanding of proteosome machinery, hopefully, we can come up more and more cool idea to utilize the system for novel therapy development.

Dana-Farber News@DanaFarberNews

New research in @angew_chem by @DanaFarber’s @JunQiLab reveals a novel chemical biology approach to achieving selective targeted protein degradation using proteosome cap region proteins directly in addition to the current PROTAC strategy, which could aid in developing therapies and cancer drugs. ➡️ bit.ly/4rbilu9

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Jun Qi Lab@JunQiLab·23 Oca

It was such a fun day to visit ⁦@PennMedicine⁩ and talk about science with ⁦@junwei_s⁩ ⁦@LilingWanLab⁩ and present our science. Thank you for having me.

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Jun Qi Lab@JunQiLab·20 Oca

Our work using cap region proteins of proteosome to directly induce targeted protein degradation is now published online @angew_chem. Congratulations to all the authors on bringing this to the finish line. Thanks @BloodCancerUtd for supporting our work. doi.org/10.1002/anie.2…

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Jun Qi Lab@JunQiLab·4 Ara

We would like to thank the support from @EpendymomaRF, @curingkidsckc and @StBaldricks that allow us to build our biology capability to explore novel therapeutic options for pediatric brain cancer.

Jun Qi Lab@JunQiLab

Our collaborative work with Prof. Mo Movassaghi at @chemistryMIT and @FilbinMariella is now online @acsJACS @ACSPublications. Thrilled to work as chemical biology part to explore therapeutic potential of these awesome nature compounds from Mo's lab. pubs.acs.org/doi/10.1021/ja…

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Jun Qi Lab@JunQiLab·3 Ara

I am thrilled to work and publish together with my postdoc PI, Prof. Mo Movassaghi @ChemistryMIT to bring their sophisticated chemistry to potential therapy development. I am excited to keep learning from Mo and @FilbinMariella. Pic from: news.mit.edu

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Jun Qi Lab@JunQiLab·3 Ara

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Jun Qi Lab@JunQiLab·21 Kas

This is absolutely fun!!! @LabSethi cannot wait to do more together. To create more and better understanding in cancers and find potential novel therapy together. @AGA_Gastro

Sethi_Lab@LabSethi

Can we have a biotinylated and inactive version of the HDAC1/2 inhibitor? How do you do Chem-seq, Jun? In the end, we were able to follow our observations and publish these findings thanks to collaborative science fostered by @DanaFarber @DanaFarberNews

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Jun Qi Lab@JunQiLab·20 Kas

It is so exciting to see the final version of our collaborative work with @LabSethi. We found that blocking HDAC1/2 pushes CRC cells out of a stem-like state and into differentiation. We will work tother more to find novel therapeutic options for CRC. authors.elsevier.com/c/1m7oK3mEmnPKi

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Jun Qi Lab@JunQiLab·17 Eki

@rosslevinemd congratulations. such a well-deserved recognition!!!!

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Jun Qi Lab@JunQiLab·21 Tem

@LabSethi it is a true pleasure to work with you and your team.

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Sethi_Lab@LabSethi·21 Tem

A great collaboration with my friend @JunQiLab. We screened a small molecule library targeting epigenetic regulators curated by Jun’s team using our dual reporter system. The ensuing mechanistic work required innovative chemical and rigorous molecular biology.

Dana-Farber News@DanaFarberNews

Proof-of-concept: Epigenetic reprogramming could one day be a new therapeutic path in colorectal cancer. @Nilay_Sethi explains how histone acetylation shapes CRC cell fate in this @AGA_Gastro study: bit.ly/46gS7z1

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Jun Qi Lab@JunQiLab·19 Tem

It is so exciting to see our collaborative work with @Nilay_Sethi is now available online. My team and I are always eager to learn more about novel therapy development for CRC together with Nilay and his wonderful team!!!

Dana-Farber News@DanaFarberNews

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Keşfet

@AlexsLemonade @StBaldricks @EpendymomaRF @sontagfdn @IronMattLarson @curingcancer @TheVFoundation @FilbinMariella