Mraz Lab

796 posts

Mraz Lab

Mraz Lab

@MrazLab

Marek Mraz research group

Katılım Ocak 2020
381 Takip Edilen546 Takipçiler
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Mraz Lab
Mraz Lab@MrazLab·
Very proud to share our new paper demonstrating that transformed follicular lymphoma has increased activity of CD40 signalling due to lower levels of miR-29. Evidence that the B-T cell interactions are important in tFL (Filip et al, Leukemia, 2026, rdcu.be/e4HwW).
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Dr Ino Agrafioti
Dr Ino Agrafioti@inoagrafioti·
I don’t know if you saw the MASSIVE news announced by @ERC_Research today: from now on,if you get a B at step 1 you are eligible to apply at N+3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! erc.europa.eu/news-events/ne…
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Mraz Lab
Mraz Lab@MrazLab·
ERC is doing some strange thing
Oded Rechavi@OdedRechavi

Announced by the ERC today (really bad news for science!!! It starts in Europe but will affect everybody) Because the REVIEWING LOAD is so bad, if your application fails you may need to wait mulitple years (>3?!?) until you can submit again! The ERC is the lifeline of the leading labs in Europe, so many research programs will be terminated (just no other sources to compensate). The letter from the ERC says “the only way is to reduce applications” (highlighted in the picture below) No!!! It's the wrong direction. Use AI to assist review. It’s not perfect (yet), but it allows more proposals to be evaluated, and it could support, not replace, human reviewers.

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Mraz Lab
Mraz Lab@MrazLab·
Moje laborka hledá lab manažera/ku - znalost češtiny je nutná
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Iannis Aifantis
Iannis Aifantis@iannisaifantis1·
To follow the @AACR "Holy Week" we are sharing our new paper out today @BCD_AACR : “3D chromosome remodeling in B-cell development and acute lymphoblastic leukemia.” Using integrative chromatin architecture, accessibility, and transcriptional analyses, we show that pediatric B-ALL subtypes harbor distinct 3D genomic states that parallel developmental arrest and support subtype-specific oncogenic programs. We further identify ERG as a key regulator in ETV6::RUNX1 B-ALL, with implications for leukemic maintenance and differentiation blockade. Finally, we map 3D changes in healthy human B cell development drawing parallels to specific disease states. aacrjournals.org/bloodcancerdis…
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Mraz Lab
Mraz Lab@MrazLab·
This brilliant paper from Greg Hannon (pubmed.ncbi.nlm.nih.gov/17554337/) led to my first paper, in which we studied miR-34a in leukemia. I am very grateful for his great science.
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Mraz Lab
Mraz Lab@MrazLab·
I learned yesterday that Greg Hannon passed away. I only met him a couple of times, but the meeting in Cold Spring Harbor when we talked about ncRNAs and ate lobster, that I will never forget. I truly enjoyed reading his papers, and his sharp intellect. cruk.cam.ac.uk/news/in-memori…
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Mraz Lab
Mraz Lab@MrazLab·
@SvobodaLab Petr, I think it is a mistake to recruit someone without their own lab ...
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Petr Svoboda
Petr Svoboda@SvobodaLab·
@MrazLab That's up to the selection committee to negotiate and evaluate that. Myself, I would prefer a director who would be more committed to taking care of the institute and leading it than to using IMG as a way to support own research career. That's also the reason I won't be applying.
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Petr Svoboda
Petr Svoboda@SvobodaLab·
1/6 This November, the Institute of Molecular Genetics, the leader in vertebrate functional genomics in Czechia, open a call for applications for its Director (starting 1.5. 2027). Whoever would seriously think about it, please, contact me. Thanks for RT. img.cas.cz/en/
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Taylor Lab UM
Taylor Lab UM@TaylorJ_MD·
Hopefully first submissions before September (that’s what is currently shown in the forecast).
NIH Innovates@NIH_Innovates

Big news for innovators, founders, and R&D-driven small companies: NIH’s Seed Fund is back in action! Thanks to new legislation, U.S. small businesses are again able to pursue up to $1.4 billion per year in Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding to power breakthrough science, build game-changing technologies, and move solutions toward real-world impact. Start planning by checking out the funding opportunity forecasts on Grants.gov. ➡️Funding opportunity forecasts: bit.ly/4ccHkIR 📌Key resources for applicants: bit.ly/3OkyeAA

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Itai Yanai
Itai Yanai@ItaiYanai·
We're in this week's Nature! We propose a model of how a cell learns by running an evolutionary algorithm: exploring different gene-regulatory combinations and using feedback responses to stabilize those combinations that reduce stress levels. Full text: nature.com/articles/s4158…
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Fórum Věda žije!
Fórum Věda žije!@Vedazije·
Z akademicekého sněmu AV: problémem české vědy není neefektivní distribuce prostředků, ale především to, že těch prostředků je málo
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Mraz Lab
Mraz Lab@MrazLab·
@konvalinka_jan @Vedazije Scientic reports je opravdu o publikovani hodne velkeho objemu clanku. Za me se podobne chova i Nature Communications,,,,
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Jan Konvalinka
Jan Konvalinka@konvalinka_jan·
@Vedazije Ten první odstavec je v podstatě správně (ve Sci. Reports se mohou objevit jak velmi průměrné, tak zajímavé práce), ten druhý je úplný nesmysl.
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Iannis Aifantis
Iannis Aifantis@iannisaifantis1·
Thrilled to see our 2019 publication (Tikhonova et al) pass 1,000 citations. In this study, we mapped in detail the bone marrow micro-environment at single-cell resolution and showed that the niche is far more heterogeneous than previously appreciated. We hope that this work helped define how we think about the cellular architecture that supports hematopoiesis. #BoneMarrow #Hematopoiesis #SingleCell nature.com/articles/s4158…
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Charles Swanton
Charles Swanton@CharlesSwanton·
People often ask how breakthroughs occur in cancer biology-often the story is more complex - the survival plot for myeloma outcomes is extraordinary - improvements come about in incremental steps - in my lifetime treatment of Myeloma has almost transformed into a curable disease
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Cancer Cell
Cancer Cell@Cancer_Cell·
Online Now: Cancer type-specific variation in patterns of driver alterations across 50,000 tumors dlvr.it/TRk4T8
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Keşfet

@GregNowakowski @Dr_Daniel_Molin @prokop_whaaat @Danielakov2 @JamieFlerlage @MarekTrnenyDr @inoagrafioti @ERC_Research