Muscle & Nerve

In this prospective multicenter cohot study, reclassification of PLS to ALS occurred at a low frequency at 1 year follow-up (7.1%). Baseline NfL was the strongest predictor in differentiating UMN dominant ALS from PLS. nam12.safelinks.protection.outlook.com/?url=https%3A%…

This multi-center retrospective study found that somatic and autonomic neuropathy are more commonly found in TTR V142I mutation patients than previously reported. onlinelibrary.wiley.com/doi/10.1002/mu…

In this cohort of patients who underwent >1 muscle biopsy, repeat biopsy achieved a specific diagnosis in 43% of cases and impacted clinical decision-making. The highest yield was when IBM was suspected, or when B1 showed non-specific myopathy. onlinelibrary.wiley.com/doi/10.1002/mu…

In this single-center study, large racial differences in time to clinical events for Black versus White ALS patients referred for NIV, AAC, hospice, and wheelchair were reported, suggesting more advanced disease or more rapid progression pubmed.ncbi.nlm.nih.gov/40065593/

This review explores the last 10-year research examining the effects of exercise interventions in many types of myopathies. Editor's choice for open access for 2 months. pubmed.ncbi.nlm.nih.gov/39976212/

Study from a single center demonstrates a large racial difference in time to clinical events for Black versus White ALS patients referred for NIV, AAC, hospice, and wheelchair. Article is Open Access for 2 months. onlinelibrary.wiley.com/doi/10.1002/mu…

Read this review on neuralgic amyotrophy focusing on an alternative treatment approach targeting motor coordination, energy conservation strategies, and behavioral change, rather than strength training. onlinelibrary.wiley.com/doi/epdf/10.10…

Be on the watch for the coming Muscle and Nerve Special Issue on PM&R expected May 2025!!

Read this review on sport-related neuropathies like traumatic irritation of the brachial plexus or cervical roots (“Burners and stingers,”) suprascapular, axillary neuropathies, UNE in throwers, UNW in cyclists, and foot/ ankle neuropathies including TTS. onlinelibrary.wiley.com/doi/epdf/10.10…

Dr. Kaminski et al explore the strengths and limitations of telemedicine in MG. As virtual care expands, standardized AI assessments enhance accuracy and outcomes. Read about their findings at #Neurology" target="_blank" rel="nofollow noopener">onlinelibrary.wiley.com/doi/10.1002/mu… #Telemedicine #MyastheniaGravis #HumanFactor #AIinHealthcare

IVIG monotherapy can be an effective 1st line treatment for HMGCR IMNM leading to marked improvements in CK and strength. Read this Editor Choice article, open access for 2 months. onlinelibrary.wiley.com/doi/epdf/10.10…

Conduction blocks were common in this French cohort of patients with neurolymphomatosis. Paying attention to other red flags like pain and monoclonal gammopathy is important in such cases. Read this Editor Choice article open access for 2 months. onlinelibrary.wiley.com/doi/epdf/10.10…

Initiation of cardiac medications when left ventricular function is normal correlates with prolonged survival in males with DMD. Read this Editor Choice article open access for 2 months at onlinelibrary.wiley.com/doi/epdf/10.10…

IVIG monotherapy can be an effective first-line treatment for HMGCR IMNM. Read this Editor Choice article, open access for 2 months. onlinelibrary.wiley.com/doi/full/10.10…

Read this Editor Choice invited review article on rehabilitation strategies of LGMD. Open access for 2 months. Limb‐girdle muscular dystrophies: A scoping review and overview of currently available rehabilitation strategies

Given the recent development of disease modifying therapeutics for certain inherited NM disorders, rehabilitation needs for this rapidly expanding cohort of patients aging with NMDs will grow. Read this Editor Choice article onlinelibrary.wiley.com/doi/10.1002/mu…

The NEURO-TTRansform trial on patients with ATTRv-PN showed that Eplontersen had a clinically meaningful effect on neuropathic impairment, QoL, and nutritional status. onlinelibrary.wiley.com/doi/10.1002/mu…

This Editor's Choice article reviews the spectrum of hereditary and immune mediated rippling muscle disease and proposes a diagnostic algorithm for the disorder. Open access for 2 months at onlinelibrary.wiley.com/doi/epdf/10.10…

NIH establishes a national ALS clinical research consortium called ALL ALS. This new consortium is a multi-institutional effort aiming to organize the ALS clinical research landscape in the US. Read the Editor Choice article describing ALL ALS. onlinelibrary.wiley.com/doi/full/10.10…

Read this Editor Choice article reporting a specialized, home-based multidisciplinary care model for ALS patients and caregivers, demonstrating both feasibility and high satisfaction. Open access for 2 months. onlinelibrary.wiley.com/doi/epdf/10.10…