Hec

How does gravity affect mitochondrial biology - and what are the implications for space travel? go.nature.com/3T1mgOl

Fun paper - by looping mRNA into circles they trap ribosomes to go round and round synthesising very very long proteins. They even get E.coli and B.sub to secrete these monsters. biorxiv.org/content/10.648…

Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance journals.physiology.org/doi/abs/10.115…

Multifactorial nature of anabolic resistance in ageing skeletal muscle: A systems modelling study physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Pediatric cancer therapy and skeletal muscle growth: An emerging role for satellite cell disruption journals.physiology.org/doi/abs/10.115…

new work from @pirinenlab suggests that NR may be able to protect from chemotherapy-induced muscle wasting biorxiv.org/content/10.648…

Reversal of protein chemical aging by enzymatic deglycation | Nature Communications nature.com/articles/s4146…

Mechanosensing at the endoplasmic reticulum by IRE1 researchsquare.com/article/rs-101…

Stimulating proteasomal degradation in human proteinopathies febs.onlinelibrary.wiley.com/doi/10.1111/fe…

Myofiber-specific knockout of TGF-β type I receptors in mice concurrently drives muscle hypertrophy, oxidative metabolism, and absolute force nature.com/articles/s4200…

The FDA has granted Fast Track designation to Satellos' oral Duchenne therapy, SAT-3247, which is designed to regenerate lost skeletal muscle. Learn more here: 📰 bit.ly/4vK5RMA

Mitochondria-sarcoplasmic reticulum crosstalk as a modulator of skeletal muscle mass link.springer.com/article/10.100…

Published in @MolecularCell, Li et al. show TMEM141 acts as a brake on complex I assembly. Under high energy demand, YME1L1/AFG3L2 degrade TMEM141, relieving TIMMDC1 inhibition and boosting complex I assembly to enhance OXPHOS cell.com/molecular-cell…

New @Nature research article: dietary cholesterol not only raises LDL—it activates RAS→Ral signaling, driving LDLR internalization and CTSA-mediated lysosomal degradation, independent of PCSK9. Blocking CTSA restores LDLR and cuts circulating LDL in mice. nature.com/articles/s4158…

What if you could record cytosolic activities or archive proteins on an intracellular tape across time? 📼 Introducing CyTRACE: a genetically encoded, modular framework built on protein tape recorders for scalable post hoc spatiotemporal analysis and molecular interrogation. 🔍 CytoSense records protease & kinase signaling activities 📦 CytoCatch archives cytosolic proteins along CytoTape Preprint out: doi.org/10.64898/2026.… 🧵Thread (1/7)

Lysine methylation as a bidirectional switch cell.com/cell-chemical-…

Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis frontiersin.org/journals/physi…

Just published on Substack: Why Epigenetic Rejuvenation Won’t Give Us Radical Life Extension — Lessons from 58 Generations of Cloned Mice. This is my take at the results of a landmark Nature Communications paper (20+ years, 1,200+ mice, 58 generations of serial cloning with full epigenetic reset) shows it still collapses. Mutations accumulated 3× faster. Epigenetic reprogramming works… until it doesn’t. There is an irreducible level of damage that cannot be undone. To my taste, this is a very important study. Popular literature claims cloning erases aging signatures. In short-lived species it may look that way — the entropic damage simply doesn’t have time to kill. In longer-lived animals we expect the picture be very different (and there is an anecdotal evidence for that with a lot fewer generation before the collapse). This is also why I dislike the language of “information theory of aging.” Flipping the sign on entropy and calling that "information" (changing from the Boltzmann to Shannon equation) doesn’t repeal thermodynamics. Of course, you can still hope for better Yamanaka factors or else. My interpretation of the experiment is not yet a proof of anything - certainly not. However, the experiment removes a lot of ground under proponents of epigenetic rejuvenation. If you want to keep your identity, better to stop aging than try to reverse it. Challenge me. Subscribe, Like & repost. Link: peterfedichev.substack.com/p/why-epigenet…

The nucleus as a mechanobiological hub in muscle aging tandfonline.com/doi/full/10.10…