Malachy

New article is up on Substack. I spent the last couple of days putting together a fully sourced breakdown of my favorite biohacks: 1) 3g of Taurine Per Day 2) Bromantane / Tyrosine / Phenylalanine 3) Walking After Meals 4) Thiamine (TTFD) + Methylene Blue 5) Baking Soda “Milkshakes” 6) K2 and MgCl Scrotal Application 7) High-Dose Vitamin K2 8) Magnesium Sips Throughout Day 9) White Button Mushrooms + EVOO 10) Breakfast in the Sun 11) Low-Dose Minocycline 12) Nicotine Patches for Focus I would greatly appreciate your support! Link in bio.

@Thermobolic I'm actually not sure. I haven't been tracking calories, but the stuff on the list is pretty simple so I'm assuming it's accurate.

@MyProtocols About right?

My diet for the past week: - 6 large eggs - 1 tbs coconut oil - 500g blueberries - 2L skim milk - 1L orange juice - 500g grapes - 350g skirt steak - 500g mushrooms - 2 creme brulee

"Functional ice cream" = vanilla ice cream from a gelateria in Italy FYI

Anon, have you eaten your "functional ice cream" for ERK1/2 and AKT activation, increased RUNX2, increased alkaline phosphatase, increased osteoblast proliferation, and bone mineral density today?

Eat more blueberries.

There's nothing I hate more than seeing someone reply "@grok is this true?" under a post with the source clearly attached. Why don't you read it yourself?

Aspirin as a treatment for erectile dysfunction.

Hamsters with a 20% higher metabolic rate lived 14–16% longer than normal. PMID: 12054192

Mice with the highest metabolic rate lived 36% longer than those with the lowest. PMID: 15153176

Source: pubmed.ncbi.nlm.nih.gov/3573976/

High-carb diets increase testosterone and lower cortisol more effectively than high-protein diets. In a 1987 study, 7 men tried two diets for 10 days each. The high-carb diet (10P/70C/20F) got most of its calories from pastries, candy, bread, vegetables, fruit, and fruit juice. The high-protein diet (44P/35C/21F) got most of its calories from meat, fish, poultry, egg whites, and a dietary supplement. Switching from the high-protein to the high-carb diet: → Increased testosterone by 28% → Lowered cortisol by 27%

@Thermobolic Why waste time drink lot water when salted watermelon do trick?

Salted watermelon = ultimate hydration drink.

@HansThorLief @ElifUnfiltered x.com/MyProtocols/st…

@ElifUnfiltered @MyProtocols Information or data on that one?

Ketamine treats depression in a fundamentally different way than SSRIs SSRIs increase serotonin by inhibiting its reuptake. Ketamine does essentially the opposite. In SSRI-resistant patients, brain imaging revealed that ketamine increases the number of serotonin 1B receptors. Activating this receptor does two things: 1) Reduces the release of serotonin 2) Increases the release of dopamine In the same study, 72% of patients responded to ketamine and 48% reached full remission - in people who had already failed SSRIs. Patients saw improvements within hours of the first infusion and side effects were transient. SSRIs exhibit a much less favorable response. In STAR*D (the largest antidepressant trial ever run) a first-line SSRI put only 28% of patients into remission, and it took weeks to get there. 70% of patients experienced an adverse event, and 1 in 5 quit the drug due to side effects. This includes (but is not limited to): - Increased suicidal ideation - Sexual dysfunction in up to half the users - Emotional blunting and anhedonia - Weight gain and metabolic dysfunction - Nausea and digestive issues - Sleep disruption, insomnia, and drowsiness - Withdrawals upon stopping the treatment The chemical imbalance theory - the claim that depression is caused by a serotonin deficiency - is not only wrong, it's likely the opposite of what's true. References: Tiger et al. (2020), A randomized placebo-controlled PET study of ketamine's effect on serotonin1B receptor binding in patients with SSRI-resistant depression Trivedi et al. (2006), Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice Moncrieff et al. (2022), The serotonin theory of depression: a systematic umbrella review of the evidence

It's associated with frequent, long-term use. The study I mentioned used a low, controlled dose of 0.5 mg/kg intravenously, followed by four open-label infusions administered twice a week. ED wouldn't be something to worry about in a clinical setting. But obviously, if you're using it regularly in high doses, it's going to be a problem.

@MyProtocols Ketamine also causes permanent Erectile dysfunction in men. So be careful with that

Short naps (under 30 minutes) are associated with better cognitive performance, better mood, and a slightly lower risk of heart disease. Long naps (over an hour) are associated with a higher risk of cardiovascular disease, all-cause mortality, metabolic disease, and diabetes.

breakfast this fine morning 6 eggs fried in coconut oil, 500g blueberries, strong coffee, 150mg armodafinil, 50mg bromantane, 300mg CDP choline, 2mg pinealon, 2mg vilon and so we begin

@PiagetianPeater Was in Berlin for a bit.

@MyProtocols Where in Germany are you ?

Acerola cherry juice. This small bottle contains 3,590 mg of vitamin C (4,471% RDA), and it's more bioavailable milligram for milligram than synthetic supplements.

We often think we need to mirror the actions of those with success in order to achieve it. They’ve accomplished great things, so wouldn’t we be more likely to succeed by copying them? It appears simple and easy to implement, which is why so many people fall into this way of thinking. I think we need to strive to be better than them. This is a task that seems impossible, because how could we achieve success greater than our idols? Actually, the same way that they did. They didn’t win by copying their role models, but by having a passion so great that the “right” thing to do announced itself and the “wrong” thing wasn’t an option in the first place. This sense of clarity comes only to people with a strong passion in what they’re doing. It doesn’t come to people who are too caught up in what their idols would do, and it doesn’t come to people who think that greatness is in the material. I think everything is downstream of that passion. Discipline, for example, appears overly constraining to most. People can’t fathom how someone can spend so much time doing one thing. It seems neurotic, crazy, and sometimes rather unhealthy. However, I think the opposite. The person who is in love with what they’re doing so deeply that they can spend their entire day doing it is in a state of freedom that far exceeds what the normal person has ever experienced. It’s a state of raw expression that breathes life into them, and allows these people to do what seems impossible. But frankly, they wouldn’t be able to have that “discipline” in the first place if they weren’t called to it. At least, they wouldn’t be able to spend their whole lives doing it. (And I think that’s the goal - to find something you can do for the rest of your life.) Your vocation is like a river. Some people are strong swimmers, and can paddle against the current (i.e. away from your calling) for a small while. But once the current strengthens, they’re pulled from the thing they spent so much energy trying to obtain. It’s much more effective to swim in the direction of the current, and move with the governing forces of our nature. This makes it sound easy, but it’s actually quite difficult. Right now, we’re swayed by an endless number of distractions. And, more often than not, people are more intent on masquerading as successful than actually achieving it. There are two important factors, and they both fall under your control. The first is direction. If you’re moving in the wrong one, it doesn’t matter how fast you progress or how good your life may seem. Sooner or later, things will break. Two inevitable outcomes come to mind. Life becomes miserable enough that you find what actually brings you fulfillment. Then, you abandon what didn’t and start from scratch. Or, you push further and realize, in the end, that you haven’t found fulfillment in the one life you were given. The second factor is consistency. You can be pointed in the right direction, doing the very thing you were called to do, and you will still face problems. The death of someone close to you, a health complication, or another misfortune that is entirely out of your control. Consistency is the thing that keeps you moving during those times, and separates the good from the great. The analogy of the river doesn’t cover all nuances, and the annoying fact of life is that some things will be boring. That’s a byproduct of the uncontrollable and a condition of the world we live in. Everyone has to pay their bills, file taxes, and do their laundry (or pay someone to do it for them). But at the end of the day, if you’re pointed in the right direction (or making your best attempt at it) and consistent despite the things out of your control, you will achieve success.