Nottingham Centre for MS and Neuroinflammation

Just released: special issue of the European Journal of Neurology: Gut Brain Axis as a possible basis for the treatment of neurological disorders. With @kvonck1⁩ (Ghent) and ⁦@RaduTanasescu1⁩ (Nottingham) as Guest Editors. ⁦@EANeurology⁩ ⁦@WileyNeuro⁩

So today begins a new era in my group’s research as we venture into the role of EBV and HERVs in the pathogenesis of MS. Collaborating with the wonderful @RTarlinton, @BrunoGran2, @RaduTanasescu1. Keep your eye’s peeled, we’ll be updating regularly.

Is there a potential for EBV vaccination to prevent MS? YES. This paper outlines the possible EBV vaccine approaches in MS and the sample size estimates. @bg42b @HarvardChanSPH @NIH @uabSOPH @CShannonLowe @GavinGiovannoni @RaduTanasescu1 @NCMSNI frontiersin.org/article/10.338…

Guilty by association? SARS‐Cov2 antibodies and MOGAD onlinelibrary.wiley.com/doi/10.1111/en…

599 patients with #MultipleSclerosis reported COVID-19 and their recovery status. Preexisting neurologic impairment or mental health problems appear to increase the risk of Long COVID doi.org/10.1212/NXI.00… #MSCOVID19 Work supported by @mssocietyuk @UKMSRegister

@KlausSchmierer We found the same in a population of over 800 patients across the UK and USA : Delaying #ocrevus treatment appears safe (no relapses, no MRI activity). Poster P826 of #ECTRIMS2021 @Helenlouiseford @ETallantyre

Central vein sign #CVS on MRI likely will decrease misdiagnosis of MS. Useful to predict radiological isolated syndrome conversion to MS. Studies ongoing to see if #CVS should be added to MS diagnostic criteria. @nikosevangelou3 #ECTRIMS2021

Iron rims seem to be prognostically important. Poster P474, reports 10 year clinical study of iron rim in WM lesions in 90 patients and found both EDSS and ARMSS were 1 step higher if patients had IRL at baseline. #ECTRIMS2021 @HibbertAimee @Cneurospirt @majudah

How should we support our MS patients when they transition to secondary progressive MS? Acceptance Based Telephone Support around the time of Transition to Secondary Progressive Multiple Sclerosis: A Feasibility Randomised Controlled Trial authors.elsevier.com/sd/article/S22…

Domestic abuse is a much under recognised and under reported major problem in MS clinics. I have just been made aware of one more patient from our MS clinic that needs support. We are on it. @NUHNeuro

A interesting Nottingham case series of Guillain-Barré syndrome variant occurring after SARS-CoV-2 vaccination, published in Annals of Neurology @NCMSNI @nottmhospitals @RaduTanasescu1 @JonathanRhysEv2 doi.org/10.1002/ana.26…

We are very pleased that the Pregnancy Register is now live. If you are pregnant and have MS then please join this important study, findings could influence how Prenancy and MS are treated #MSpregnancyregister @mssocietyuk @muMS_UK ukmsregister.org/pregnancy @drruthdobson

@RaduTanasescu1 @Cneurospirt are co-authors in this paper on microbiota changes after hookworm infection. It’s the first study showing what the hookworm does in people with #ms; it promotes microbiota microbial diversity (lacking in the placebo group) pubmed.ncbi.nlm.nih.gov/33853585/

@nikosevangelou3 👏

🌈 This evening, the QMC will be light up in rainbow colours, as #TeamNUH remembers all of the lives lost and all those affected by the pandemic. 💙 The last twelve months have been difficult for so many, and we hope that better, brighter days will be here soon.

Look what has been published today! Prognostication and contemporary management of clinically isolated syndrome jnnp.bmj.com/content/92/4/3…

PhD studentship to work on MEG in rehabilitation of #TBI. Excellent opportunity. Collaboration of the national rehabilitation centre @NRCrehabUK and the @MedicineUoN @UoN_Physics @MattBrookesMEG continuing our work on #MEG in TBI nottingham.ac.uk/jobs/currentva…

Preventing #MS is a hot research topic; please visit the link for further information about the submission requirements👇@bg42b @RaduTanasescu1 @drruthdobson #overview" target="_blank" rel="nofollow noopener">frontiersin.org/research-topic…

Great news 🌟

The government have announced 1.7 million more people will be added to the shielded patient list in England. This means some people currently in vaccine priority group 6 (which includes everyone with MS under 65) will now be moved up into group 4 and advised to shield. (1/4)