NEJM

A new Clinical Practice article summarizes the pathogenesis, diagnosis, and management of Barrett’s esophagus, a reflux-related condition with increased adenocarcinoma risk, highlighting endoscopic diagnosis, surveillance, and early curative therapy. Read “Barrett’s Esophagus” by Rebecca C. Fitzgerald, MD (@RFitzgerald_lab), from the University of Cambridge (@cambridge_uni): nejm.org/doi/full/10.10… #Oncology

Perspective by L. Maini et al.: Medicaid’s GENEROUS Most-Favored-Nation Pricing Model — Promise and Limitations nej.md/4tlYqt1 #HealthPolicy

Original Article: Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention (CHIP-BCIS3 trial) nej.md/4lR1vyX Editorial: The Price of Protection — Microaxial Flow Pump in High-Risk PCI nej.md/4uPFViv #Cardiology

New in our partnership with @DGlaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free: nej.md/DrG40

Among adults 50 years of age or older, fewer cases of confirmed influenza-like illness were observed with an mRNA influenza vaccine than with standard vaccines. Reactogenicity was higher with the mRNA vaccine. Full phase 3 Fluent trial results and Research Summary: nej.md/4nfu2z8

The hantavirus outbreak has raised two major concerns for @PaulSaxMD — and neither is directly related to the outbreak itself. Learn more in a new blog post: voices.nejm.org/doi/full/10.10…

Cerebral amyloid angiopathy is an age-associated cause of cerebral hemorrhages, cognitive decline, and transient neurologic episodes that can mimic transient ischemic attacks. Learn more about the diagnosis and treatment of this disorder in a new review: nej.md/4n9BPyc

Images in Clinical Medicine: Erythema Multiforme nej.md/3RoEOac #Dermatology #InfectiousDisease

The cruise ship hantavirus outbreak worries me for two reasons: 1. The absence of a clear, trusted public health voice from the US. 2. The temptation to reassure or alarm prematurely while the investigation is still evolving. @NEJM Link in reply:

The Corporatization of U.S. Health Care by Jatin M. Vyas, MD, PhD: From Mission to Margin in Academic Medicine — The Impact of Corporate Medicine on Medical Training nej.md/42nZ2Do #HealthPolicy #MedEd

This article was retracted on 4/29/26 at the authors’ request, with this explanation: We were unaware of Journal policies on image manipulation and had altered our submission by using an artificial intelligence (AI) tool to move the ruler to the top of the image. We therefore wish to retract our image and case report. The full retraction is available at NEJM.org.

After inhaling smoke from a forest fire for several hours, an 87-year-old man presented to the ED with difficulty breathing. He rapidly developed respiratory failure, and a flexible bronchoscopy revealed bronchial casts from inhalation of particulate matter from the smoke. Read the full case details: nejm.org/doi/full/10.10… This video is part of an #EarthDay2026 spotlight illustrating the effects of the climate crisis on clinical health. View more resources at nejm.org/browse/special…

This article was retracted on 4/29/26 at the authors’ request, with this explanation: We were unaware of Journal policies on image manipulation and had altered our submission by using an artificial intelligence (AI) tool to move the ruler to the top of the image. We therefore wish to retract our image and case report. The full retraction is available at NEJM.org.

An 87-year-old man presented with difficulty breathing after having inhaled thick smoke from a forest fire for several hours. Respiratory failure developed. On flexible bronchoscopy, black casts were seen in the airway. Read the full case details: nejm.org/doi/full/10.10…

Clinical Problem-Solving: Immune Interference nej.md/4necBPa #InfectiousDisease #Immunology

🧵 Health inequities across Chicago reflect structural differences in housing, food access, education, employment, and safety, producing stark gaps in outcomes, including a 24-year life expectancy divide between the Loop and West Garfield Park.

Among patients undergoing complex PCI, elective unloading with a microaxial flow pump did not reduce the risk of major adverse clinical outcomes as compared with standard care. Full CHIP-BCIS3 trial results and Research Summary: nej.md/4lR1vyX

Neha J. Pagidipati, MD, and Donald Lloyd-Jones, MD, discuss common symptoms of heart failure with preserved ejection fraction (HFpEF) and why they occur. Watch “HFpEF Explained — Living with HFpEF,” part three in a three-part Double Take video miniseries, now available on our YouTube channel.

Images in Clinical Medicine: Cerebral Amyloid Angiopathy nej.md/3RoENTG #Neurology #Radiology

Original Article: Base Editing of HBG1 and HBG2 Promoters for Sickle Cell Disease (BEACON study) nej.md/3NZbo13 #Hematology

Science behind the Study: Advances in RAS Therapeutics for Pancreatic Cancer nej.md/4neOTCE #Oncology #Gastroenterology

In the final episode of a three-part Double Take miniseries on heart failure with preserved ejection fraction (HFpEF), Lori Hogan and Janice Williams describe what living with HFpEF is like. This patient-focused video explains the condition and offers practical approaches to managing it as a chronic illness. Watch now: youtu.be/9m-G70cnqsY

Resident physician Naomi T. Nkinsi, MD, MPH, discusses how race was historically built into clinical formulas for diagnosing kidney disease and how clinicians speaking out about the inequities of care are imparting change. Explore this issue in episode 1 of Intention to Treat. 👉 nej.md/48P6xaa