Nicole Bender

@MELanocyteMD @HENRYY_MD @Gloria_SuraMD @DrAldehyde @MightyDermPath @TristanRutland7 @AhmedShahMD @SumantaDas_7 @PathBst @SimonRoyMD Nice example 😍😍

Localized Tenosynovial Giant Cell Tumor: 1️⃣ Multilobulated, dense fibrosis 2️⃣ Mononuclear neoplastic cells (epithelioid/plasmacytoid) 3️⃣ Variable GC's, foamy histiocytes, hemosiderin Learn more: ✳️ youtu.be/AXvdZDBcBVk ✳️ kikoxp.com/posts/14006 #3thingstoknow #bstpath

And finally Silicone These are empty lipid-like vacuoles, variably sized, within histiocytes. You frequently need history to help inform you to make this diagnosis, as some artifact can mimic these changes

Calcium Hydroxylapatite (Radiesse) This is very distinctive, with grey-green granular microspheres. These microspherules are not refractile under polarizable light.

50s F cheek - clinical ddx: cyst vs. foreign body rxn - pt had history of soft tissue augmentation #dermpath #pathtwitter #dermtwitter #pathology #dermatology #residenteducation #backfromsummerhiatus

@PathologoP Tissue culture-like fibroblasts resemble those grown in the lab on plates. They are stellate and elongated with finely tapered ends (which adhere to the dish or plate).

80sM - neck/shoulder area - clinical ddx: Lipoma #pathology #PathTwitter #dermatology #dermtwitter #dermpath #residenteducation #tweetorial

First of 4 videos on what may be called Ewing Family of Tumors. This is Ewing #BSTPath PS I'm so old that I remember using PAS and PAS/D to make a diagnosis of Ewing😱

@94_inno @JMGardnerMD @DrGeeONE @TristanRutland7 Pretty! Agree myofibroma :)

A 70 yo man presents with a nodule on his right dorsal hand. Here are the histological findings. What's in your differential diagnosis? Would you recommend any IHC? #dermpath #pathology #dermtwitter #dermatology @JMGardnerMD @DrGeeONE @TristanRutland7

Ddx: Rhabdomyosarcoma - Desmin+, polygonal cells w/ more eosinophilic cytoplasm & more severe cytologic atypia + atypical mitoses, may contain cross-striations - proliferative fasciitis usually has mitoses, but should not have ATYPICAL mitoses - also wrong pt characteristics

Ddx: Nodular fasciitis - does not contain these characteristic ganglion-like cells Ddx: Ganglioneuroma - S100+, contains Schwann cells, fibrillar background lacking significant component of fibroblasts/myofibroblasts & wrong pt (too old + this tumor not really seen in skin)

@Madhury57496817 @MELanocyteMD Great call!