Nico Wenner

Truly excited to see our latest article, in which we were surprised how phages that target conjugative plasmids are both so common and diverse, published! A real tour de force from @nquinoneso and @implosian nature.com/articles/s4146…

@BioMickWatson Yes that's possible, thanks for your thoughts!! This work left us with many hypotheses&questions! Hope to be able to test them in vivo, one day.

@NWenner Could this be immune response avoidance by avoiding too-fast growth in the presence of succinate in specific niches? I seem to recall fast growing Salmonella are cleared by the host more quickly than slow growing

If you ever wondered why your favorite enteric bacterium does not grow well on a particular carbon source, despite carrying all the genes required for uptake & catabolism, this thread is for you ‼️ @PLOSGenetics

Do you know why mutation in the 16S RNA anti-Shine-Dalgarno & the presence of subinhibitory concentration of chloramphenicol do stimulate utilisation of succinate?? Happy to hear your suggestions!

We propose that multiple genetic regulatory systems, including RNA binding protein & small RNAs are involved in tight regulation of succinate utilisation. We speculate that environmental stimuli can modulate succinate utilisation via these systems

Delighted that our latest publication is now out in Nature Microbiology!Through the combined power of genomics and epidemiology, we detail the evolutionary steps involved in shaping Salmonella variants responsible for bloodstream infection in Africa. Details in thread below!