Deborah Naon

Very interesting: mTORC2-NDRG2-CDC42 axis drives mitochondrial fission indipendently of DRP1

@AboutPatna @orozco_lab @IRBBarcelona @AntonioZorzano Thank Tomás!

@NaonDeborah @orozco_lab @IRBBarcelona @AntonioZorzano Congrats for this great work Deborah!

The results of the beautiful collaboration with the lab of @AntonioZorzano are out in Science! In the paper, we modeled how previously uncharacterized isoforms of MFN2 provide mechanical tethering between mitochondria and ER. Video made with #molywood 🙂 science.org/doi/10.1126/sc…

@albert_qr78 @LabScorrano Thank you Albert for your help!!

Extremely happy to be part of this. Great stories need time. I remember helping out with the RPAs (was my forte back in the day) during my final year of PhD... just 14 years ago 😀. Congrats to @NaonDeborah, Antonio's lab and @LabScorrano for pursuing it!

@TheVilchezLab @LabScorrano @carlescanto @AntonioZorzano @SatokoS_PhD Thank you, David.!!!

@LabScorrano @carlescanto @NaonDeborah @AntonioZorzano @SatokoS_PhD Congrats Deborah and colleagues! Very happy to see this story out

@NaonDeborah's paper, 8y of collaboration with @AntonioZorzano's lab is out! Kudos to Deborah, @SatokoS_PhD and all authors! Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria | Science t.ly/UezR #MCS #mitochondria #ER 1/

@carlescanto @TheVilchezLab @LabScorrano @AntonioZorzano @SatokoS_PhD Remember the origin of variants !! Nice times at IRB!!!!

@TheVilchezLab @LabScorrano @NaonDeborah @AntonioZorzano @SatokoS_PhD Indeed! I recall the initial discussions with Deborah about Mfn2 splicing during my time in the Zorzano lab! Very happy to see how much the story progressed during this time at the @LabScorrano! Congratulations to all!

@carlescanto @TheVilchezLab @LabScorrano @AntonioZorzano @SatokoS_PhD Thank you Carles. We are so happy!!!

@jourdainlab Thank you !Alexis

Splicing x mitochondria 💯 loving it Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria | Science science.org/doi/10.1126/sc…

@iannisaifantis1 @LabScorrano Thank you Iannis!!

An impressive piece of work on alternative splicing of MFN2 and Mito:ER tethering by the @LabScorrano and colleagues! science.org/doi/10.1126/sc…

@glytsou @LabScorrano Thank you Christina!!!

Splice variants of MFN2 shape the endoplasmic reticulum and tether it to mitochondria Congrats to Deborah, @LabScorrano and the team for this elegant study! So nice to see this story out! science.org/doi/10.1126/sc…

@orozco_lab @IRBBarcelona @AntonioZorzano Thank you Orosco Lab for your great work.!!!

Ermin2 and Ermit2 do not influence mitochondrial morphology. Ermin2 regulates ER shape and luminal connectivity. Ermit2 is enriched in MAMs. Ermit2 increases ER-mito proximity measured by ddGFP, FEMP, EM. In cells, Ermit2 supports Ca2+ transfer from ER to mitochondria 3/

Mfn2 tethers ER to mitochondria, but what's its partner on the ER? How does it tether heterotypic organelles without fusing them? Deborah discovered that Mfn2 is alternatively spliced in two variants Ermin2 and Ermit2 that lack the GTPase domain and go only to the ER. 2/

In the liver, Ermit2 facilitates ER-mitochondria phospholipid transfer, reduces ER stress caused by Mfn2 ablation and in models of NASH. Molecularly, Ermit2 CC2 domain is required to interact with CC1 and CC2 of mitochondrial Mfn1&2, in a complex apt to stabilize ER-mito 4/

This was a very long journey... Thanks @NaonDeborah for your ingenuity and perseverance. She is a star, look out for her next discoveries. Thanks @ERC_Research @FondationLeducq @MDAUSA @mur_gov_ for support, @VIMMPadua @DiBio_UniPD @IRBBarcelona for making this possible. 6/6 LS

@LabScorrano @ERC_Research @FondationLeducq @MDAUSA @mur_gov_ @VIMMPadua @DiBio_UniPD @IRBBarcelona I thank you, Luca, for your full support and perseverance throughout good and bad times! I'll never forget it!.

@LabScorrano @LukashAllan @AnnaPellattiero Congratulations!!! Fantastic work!

Thrilled to share the latest groundbreaking research by Martina Semenzato! sciencedirect.com/science/articl…. 8 years of dedication, a fantastic collaboration w/ Fabio Di Lisa, Tish Murphy, Mark Kohr, Petra Alanova, and Roberta Menabò. @LukashAllan @AnnaPellattiero #Opa1 #Mitochondria 1/