Dr Laurie K Mischley

To surround yourself with people who know what needs to be done…and do it.

@purposeful_pd Sending you love from Seattle.

Just wanted to thank everyone for the wonderful support after the passing of my wife, Amy, due to brain cancer complications. Haven’t been able to respond to everyone yet. But I have or will catch up on your posts in due time. Need more time with family right now.❤️

@DonKel5757 @MichaelOkun I originally designed it for a study in 2012 (because none existed that could do the job), but many other people have helped bring it to where it is now.

@NatNeuro @MichaelOkun You use and invented it, didn't you? Good tool.

Persons with #Parkinsons do you want a staging simple staging system to replace research scale Hoehn and Yahr to answer: Where am I w/ my disease? Would you be open to categories? Maybe a number for motor, one for mood, one for cognition, one for autonomic? Or something Similar?

@ThatEricAlper Proper nouns.

Some patients get irritated when their doctors run late, mine just sing the blues 🎶🎤Nelson Adler, you made my week!

@MichaelOkun @MayoClinic @MichaelOkun Sanity! And according to our recent study, people supplementing w homocysteine-lowering vits reported fewer symptoms over time. pubmed.ncbi.nlm.nih.gov/36839160/

Why should levodopa treated #Parkinson all be on B12, B6 and folic acid? Review Ahlskog @MayoClinic levodopa elevates #homocysteine because COMT metabolism. Accumulating deficiencies #vitamins substrate for homocysteine elevation. One Flintstone enough! prd-journal.com/article/S1353-…

In only a few weeks, the Parkinson Symptom Tracking App has users from 101 different countries! The capacity to assess and deliver healthcare globally is mind-blowing. #parkinsons #globalhealth

The Parkinson Symptom Tracking (PRO-PD) App allows PwP to generate reports to share with their doctors. Please tell us what you like/ don't like about the report - we get one round of edits! (pd-symptoms.com) #parkinson #Parkinsonsdisease #Parkinsons

Our new paper showing mitochondrial dysfunction (low NAD+ and ATP) is associated with worse PD symptoms. This is especially exciting in light of the NADPARK /NOPARK studies, currently attempting to boost NAD+ and ATP. mdpi.com/2072-6643/15/4…

Anonymous gift-giving is next level. This person knows me so well and I don’t know them at all- that experience is a gift upon a gift. Thank you, Friend

Excellent advice: Keep it simple & focus on getting the good stuff in

@SYMBYXbiome This was only an attempt to see where the fish are biting. We asked, “which if these have you used consistently for the past 6 mo?” It is possible that something not shown to be effective here may help w symptoms, but not overall progression.

@NatNeuro Hi @NatNeuro. Could you please elaborate on how red light therapy was used by people with #parkinsons in this survey? We develop infrared #laser device for PWP and have great results in clinical trial and real life - better sleep, digestion, mood, energy etc. #PDCare #SYMBYX

Over-the-counter supplements associated with fewer Parkinson’s symptoms over time. Thanks to the MVP-Study.com participants. Link to full paper here: mdpi.com/2072-6643/15/4…

@LevitanAndrew Anecdotes are case reports. This is a cohort study of 1000+ people w PD. Not all situations are appropriate for double-blind RCTs, eg tobacco->lung cancer, DES—> birth defects, seatbelts, etc. meaningful information can come from well-designed observational studies.

@NatNeuro Unfortunately anecdotal “studies” like these require extreme caution. W/o true scientific data , risk is that some of these meds can actually make PD or other comorbidities worse (by unreported interactions, toxicities etc). Till then, prefer very healthy diet as alternative.

@djclairemj @elegantfowl @purposeful_pd It’s a geographical thing, like iodine, not a diet thing. Until there is standardized litithiation of depleted water supplies, consider testing and fortification. 5-20 mg/d, not the 900-2000mg/d used in psychiatry.

Twitter is a strange mofo. Seems like something Parkinson’s community would be eating up. This is gold! 🙏I’m going from zero supplements to at least 5 starting tomorrow.

@djclairemj @elegantfowl @purposeful_pd Lithium is an essential trace mineral, many folks are deficient, and the consequences are neurological/psychological. Pharmacological dosing has fallen out of favor lately, while folks are waking up to the need for physiological doses.

@ThePeterMartens The lower the PRO-PD score, the better. You can get your own PRO-PD score and see how your score compares to others with the free Parkinson Symptom Tracking app (PD-symptoms.com)

@NatNeuro So what’s the difference between +/- in this chart, which end would be more beneficial for Parkinson’s?

@purposeful_pd @WeCanThrivePD All data were adjusted for years since diagnosis, so we are accounting for change over time. The longitudinal analysis is underway and, at least for food, doesn’t change much.

@WeCanThrivePD @NatNeuro There appears to be association between supplements and symptom severity. Rate of disease progression is another matter and doesn’t seem determinable here.