Nathaniel David

you can't un-see this

Naked mole-rats pulled a cosmic prank on biology: by swapping four amino acids in cGAS, they flipped a gene that normally summons the apocalypse into one that repairs the genome. pubmed.ncbi.nlm.nih.gov/41066557/

cool result. turns out you need the right sugar coating on your blood vessels as your age to keep them from leaking into your brain.

our educational system is extremely unfun. you're forced in a classroom metabolizing lifespan for 8 hours a day, cramming homework, memorizing lists... we want creative project-based learning. 1:1 tutoring. personalized, self-paced lesson plans. joy and mastery drive discipline!

This is like AlphaFold, but for protein localisation rather than folding It's a deep learning model that predicts a protein's subcellular compartment based on its amino acid sequence alone:

CAR T cells have shown efficacy in blood cancers and autoimmune disease. In my lab’s recent preprint, we developed CAR Tregs to tackle the #1 cause of human mortality - heart disease. biorxiv.org/content/10.110…

cool

In my 40 years of biotech, I was waiting to see this result. Never before have transplanted cells survived normal immune response without immunosuppression. Excited for patients, many whom I know see hope today for a possible cure for many diseases. globenewswire.com/news-release/2…

2024's top 10 advances in medicine (🧵) 1. The numerous benefits of GLP1R agonists As well as causing weight loss, GLP1s can prevent complications of obesity (diabetes, liver fibrosis, kidney disease, osteoarthritis), treat heart failure, and even slow down Parkinson's:

This is what the internet was made for

GDF15 positioned as a dynamic biomarker of psychosocial stress accessible in human blood and saliva, pointing towards a shared psychobiological pathway linking mental and mitochondrial energetic stress. biorxiv.org/content/10.110…

have to do it manually now alas

You can check out your foxo3 status using your 23&me raw data.

@MitoPsychoBio cool unpublished result apropos of this. We irradiated over a dozen different cell lines in culture (e.g. IMR 90) and found the most common elevated factor secreted by cells when made senescent via radiation was this very same molecule: GDF 15 @MitoPsychoBio

If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physical and mental illnesses is the **same protein** as the top marker for mitochondrial diseases: GDF15 When mitochondria cannot flux energy properly, the cell makes and secretes GDF15 in the blood to alert other cells Some highlight by Cynthia Liu in our group: - GDF15 is the top predictor for most diseases - GDF15 associated with diabetes is among the most significant protein-prevalent disease associations Based on p-value, GDF15 was most significantly associated with disease. - “GDF15 was associated with the most diseases, containing 205 prevalent and 397 incident diseases, generally acting as a risk factor except for three incident diseases (respiratory diseases affecting the interstitium, disorders of magnesium metabolism, and peripheral artery disease).” - “GDF15, similar to its high ranking with protein-disease pleiotropy, ranked second for protein-trait associations, boasting a substantial 428 associations.”Significant associations with many lipid metabolite markers. - Mental disorders like anxiety disorders, depression, and mood disorders, along with mental health-related traits, also exhibited substantial proteomic signatures including elevated GDF15 - “The fluid intelligence score and various types of dementia shared significant proteins such as NEFL and GDF15 (Figure 2G)” - “GDF15, the protein with pleiotropic effects, was causally associated with several autoimmune diseases, including ulcerative colitis and rheumatoid arthritis (Figure 6B).” Data from >53,000 people in the UK Biobank Full paper here: cell.com/cell/fulltext/… Resource to explore your favorite protein or disease/trait of interest: proteome-phenome-atlas.com

brawhaha. DOSE!!! @Aiims1742 @LifeSciVC @matthewherper

@LifeSciVC @matthewherper @statnews A missed opportunity to name this D.O.S.E. (Department Of Startup Efficiency). 🐕 Good luck to @nes047 and @NathanielEDavid!

yay, bruce! @LifeSciVC

🧬What are protein language models (PLMs) actually learning about biology? Our paper introduces InterPLM - a framework that reveals interpretable features in PLMs using sparse autoencoders, giving us a window into how these models represent protein structure and function. 🧵(1/9)

so then the bartender asks…. the regular? endpts.com/jupiter-bioven…

so 2 guys named Ned walk into a bar . . . statnews.com/2024/11/19/jup…

Molecular dynamics simulations in mixed reality! With @labriataphd and @lucien_krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies. Stay tuned, lots of cool stuff coming soon! @threejs #WebXR #Quest3