Nature Methods

Qian Chen, @yifan_ucsf & Amir Yacoby are the keynote speakers presenting at @PrincetonMSE this October. Submit an abstract or secure your seat to hear the latest advances created by electron microscopy, AI, and the next generation of instruments. 🎟️📜➡️go.nature.com/4vTFdBx

NicheTrans: a multimodal framework for translation of spatial data across modalities. nature.com/articles/s4159…

A standardized file format and open-source software suite for Brillouin microscopy, from @Prevedel_Lab @KElsa909 and colleagues. nature.com/articles/s4159…

In our latest Points of View column, Jambor and Lex cover scientific web applications for creating biological data figures. nature.com/articles/s4159…

Our latest Registered Report presents the results of a study to evaluate the performance of sequence-based protein localization predictors. @Prof_Lundberg nature.com/articles/s4159…

EviAnn leverages gene expression and protein sequence homology evidences for high-accuracy and efficient genome annotation. @StevenSalzberg1 nature.com/articles/s4159…

ClairS accurately detects somatic small variants using long-read sequencing data from tumor-normal pairs. @SineZheng @LaysonChenL @aquaskyline @HKUniversity nature.com/articles/s4159…

RNAbpFlow generates all-atom RNA conformational ensembles for single-chain RNA monomers without the use of evolutionary information or homologous structures. nature.com/articles/s4159…

High-resolution spatial lineage tracing in the DARLIN mouse model with Spatio-DARLIN. nature.com/articles/s4159…

EasyGrid: a fully automated, modular platform for high-throughput sample vitrification for cryo-EM and cryo-ET. nature.com/articles/s4159…

Read the Research Briefing highlighting this work, here: nature.com/articles/s4159… @JhuaplMark @INBT_JHU @hopkinskimmel @KennedyKrieger @HopkinsKavli

A miniscope with cloud-based operation and multicontrast capabilities enables continuous recording of neuronal activity, hemodynamics and cellular dynamics over multiple days. @JohnsHopkins @HopkinsMedicine @JHUBME @JHUECE @HopkinsNeuro @Hopkins_Rad nature.com/articles/s4159…

Read the News & Views highlighting the work here: nature.com/articles/s4159…

A new study reports successful derivation of elephant induced pluripotent stem cells. @evappleton nature.com/articles/s4159…

Read the News & Views highlighting the work, here: nature.com/articles/s4159…

A method combining open-top light-sheet microscopy with computer numerical controlled milling allows high-precision 3D tissue microdissection. nature.com/articles/s4159…

SmartTrap: an optical tweezers platform that integrates real-time 3D particle tracking, electronics and microfluidics for single-molecule biophysics and cell mechanics experiments with minimal human intervention. nature.com/articles/s4159…

Read the associated Research Briefing here: nature.com/articles/s4159…

HiCFoundation: a foundation model trained on Hi-C data for comprehensive 3D genome and epigenomics analysis. nature.com/articles/s4159…

BioFile Finder (BFF): a free and open-source application that transforms image metadata into an interactive, searchable and browsable dataset. bff.allencell.org nature.com/articles/s4159…