NEJM

A new Clinical Practice article summarizes the pathogenesis, diagnosis, and management of Barrett’s esophagus, a reflux-related condition with increased adenocarcinoma risk, highlighting endoscopic diagnosis, surveillance, and early curative therapy. Read “Barrett’s Esophagus” by Rebecca C. Fitzgerald, MD (@RFitzgerald_lab), from the University of Cambridge (@cambridge_uni): nejm.org/doi/full/10.10… #Oncology

Brepocitinib — an oral, selective inhibitor of tyrosine kinase 2 and Janus kinase 1 that blocks cytokine signaling — might improve disease activity in patients with dermatomyositis. Research findings from the phase 3 VALOR trial are summarized in a new Quick Take video. nej.md/4fkgBvD

Presented at #ATS2026: Among patients with traumatic hemorrhage, prehospital transfusion of whole blood did not result in lower 30-day mortality than transfusion of plasma or red cells. Outcomes did not differ according to the storage age of blood. Full phase 3 TOWAR trial results: nej.md/4uPFGn0 @atscommunity

Presented at #ATS2026: Among patients with idiopathic pulmonary fibrosis, inhaled treprostinil led to a smaller decline in forced vital capacity than placebo over 52 weeks. Cough and drug discontinuation were more common with treprostinil. Full results of the phase 3 TETON-1 and TETON-2 trials: nej.md/3PeZwZG @atscommunity

Presented at #ATS2026: Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the emergency department with wheezing, regardless of whether they tested positive for pathogenic bacteria. Full AZ-SWED trial results: nej.md/42wAs3o @atscommunity

An analysis of current causes of deaths among U.S. children and adolescents underscores the need for sustained investment in prevention, research on injury and overdose treatments, and readiness in emergency settings. Full results: nej.md/4foXJeW

TELIGAN trial: Telitacicept, a recombinant fusion protein that dually targets and neutralizes both BAFF and APRIL, had clinical efficacy in a phase 2 study of IgA nephropathy. Findings of a phase 3 study are summarized in a new Quick Take video. nej.md/4d8eqtV

A 55-year-old man presented with cough, chest pain, and worsening dyspnea after being trapped in a burning house for 10 minutes. Bronchoscopy revealed carbonaceous deposits that extended along the airway (shown in a video). Read the full case details in the Images in Clinical Medicine article “Inhalation Injury from House Fire Smoke”: nej.md/4uI0YTf

There are times when something as apparently mundane as a patient’s small black suitcase full of medical supplies can remind a physician of both the ordinary and the extraordinary of their chosen field. Read the Perspective essay by Christie Rampersad, MD (@ChristieRamper1): nej.md/42w7osI

𝐍𝐞𝐰 𝐈𝐦𝐚𝐠𝐞 𝐂𝐡𝐚𝐥𝐥𝐞𝐧𝐠𝐞: A 57-year-old woman with a history of osteopenia presented to the emergency department with left wrist pain after slipping on ice and landing on her palm. Physical examination and a lateral radiograph of the left wrist are shown. What is the most likely diagnosis? Submit your answer or see how others responded: nej.md/IC05142026

NEJM Editorial Fellow Katerina Lin, MD, unpacks the science behind a study on restoring vision for patients with age-related macular degeneration (AMD) and geographic atrophy. Read the full editorial: nej.md/4jP8uYs

Phase 3 SCORPIO-PEP trial: Covid-19 continues to impose substantial global burdens. Research on ensitrelvir, an oral SARS-CoV-2 3C-like protease inhibitor, as postexposure prophylaxis in household contacts is summarized in a new Quick Take video. nej.md/4uMjdXL

A 50-year-old man presented to the ED with a 1-month history of headache and worsening weakness of the left arm and leg. Brain MRI showed an enhancing lesion with extensive surrounding edema. Read the full case details in the Images in Clinical Medicine article “Cerebral Syphilitic Gumma”: nej.md/4noRZnL

The history of race-based correction of lung-capacity measures can be traced to a pre–Civil War belief among slave owners that slaves had naturally inferior lung capacity. Despite work to show that race-corrected spirometers mask lung-disease severity in Black patients, the majority of U.S. hospitals still use them. Listen to the latest episode of Intention to Treat: nej.md/3RsGBLv

Self-insured U.S. employers face skyrocketing health care bills, write Zirui Song, MD, PhD, and @suhas_gondi, MD, MBA, in a new Perspective, but they can work together to boost their businesses, raise workers’ pay, and improve the appropriateness of care for their plans’ enrollees. Learn more: nej.md/4uORd5W

For patients with acute ischemic stroke, endovascular thrombectomy has improved outcomes in large-vessel occlusions, but its benefit in medium-vessel occlusions remains contentious. Research findings from the ORIENTAL-MeVO trial are summarized in a new Quick Take video. nej.md/4nryA5z

In an @NEJM Clinical Problem Solving case, a 62-year-old man presented with malaise, anorexia, rash, and diffuse lymphadenopathy. Read the summary and comment from @ClementLeeMD: nej.md/3QYaB1P

A 57-year-old woman with a history of osteopenia presented to the emergency department with left wrist pain after slipping on ice and landing on her palm. Physical examination and a lateral radiograph of the left wrist are shown. What is the most likely diagnosis? Submit your answer or see how others responded: nej.md/3QYQbpr

The authors of a new Perspective write that a further digital divide affecting financially, racially, and geographically marginalized groups may develop in the use of health care AI, but some policy approaches could help reduce that gap. Read the Perspective by @DavidBlumenthal, MD, MPP, Kevin J. Bennett, PhD, and John E. McDonough, DrPH, MPA: nej.md/42wLCoM

A 64-year-old woman presented with fatigue, memory changes, and falls. MRI of the head revealed numerous hyperintense foci in the white matter on fluid-attenuated inversion recovery images. What is the most likely diagnosis in this case? Read the case details and vote: nej.md/4uRZ0A1

Dr. Aaron Baugh, a Black pulmonologist in California, believed that using race-correction in lung-function tests was a way to reduce health inequities. That was until he ran the numbers himself. Shocked by the results, he began to study the harmful effects of race correction on Black patients with lung disease. Part two of 𝙏𝙝𝙚 𝙍𝙖𝙘𝙚 𝙀𝙦𝙪𝙖𝙩𝙞𝙤𝙣 uncovers the racist myths that led to today’s lung-function testing with Harvard historian of science Evelynn Hammonds and Brown professor Lundy Braun. Why is the race-corrected interpretation of spirometer test results still used by a majority of U.S. hospitals, when scientists have documented that the practice is harming patients? Explore this topic in the latest episode of the Intention to Treat podcast: nej.md/48P6xaa