Michael Mao, M.D.

🔦✅Fibrillary Glomerulonephritis (FGN) : Classic Diagnostic Features Renal biopsy: Mesangial expansion + irregular capillary wall thickening with PAS-positive, silver-negative deposits. Congo red negative. 🔬 Immunofluorescence (IF) (classic polytypic pattern): - Bright IgG (often IgG4 > IgG1, polyclonal) - Both κ and λ light chains positive (no restriction) - C3 positive (often 2–3+) - Variable IgM/IgA (usually weak/negative) ⚡ Electron Microscopy (EM) : pathognomonic: - Randomly oriented, straight, non-branching fibrils (mean ~18–22 nm diameter, range 12–24 nm) - No hollow centers (distinguishes from immunotactoid GN) - Deposits in mesangium, GBM, subendothelial ± subepithelial spaces 🧬 DNAJB9 immunohistochemistry: - Strong, diffuse glomerular positivity (mesangial + capillary wall) , highly sensitive & specific (>95%) for FGN - Now considered the gold-standard confirmatory marker (revolutionized diagnosis even when EM is unavailable) 🔦✅Monotypic (monoclonal-appearing) FGN: - Rare subset (~3–11% of cases) - Shows light-chain restriction (e.g., lambda or kappa) ± IgG subclass restriction (often IgG1) - Most DNAJB9+ monotypic cases do NOT have detectable circulating monoclonal gammopathy or underlying plasma cell/lymphoproliferative disorder (paraffin IF often needed to confirm true monoclonality) - Still evaluate for paraprotein-related disease (SPEP/UPEP, bone marrow, etc.) in monotypic cases @MayoClinicNeph

Happy thank a resident/fellow week! A sincere thank you to each of our future colleagues. Your hard work behind the scenes, teamwork, and professionalism make a meaningful difference every day. It is a privilege and I’m grateful to learn with you as we work to improve lives.

😃🙏🏻 Please join us for AI in Nephrology: A Hands-on Primer Workshop📍 New York Academy of Medicine | New York, New York 🗓 March 16–17, 2026 asn-online.org/ai There are abstract submission opportunities as well as American Society of Nephrology @ASNKidney grant opportunities available for eligible participants. This is a hands-on, clinically grounded AI workshop designed with kidney care as the central use case throughout the program. 📝🤝 📍This workshop is intentionally multidisciplinary. No prior AI experience is required. Sessions are structured to engage participants across experience levels, from first exposure to early implementation. Call for Abstracts Fellows, residents, trainees, junior faculty, and graduate students are strongly encouraged to submit abstracts, including: Original research Applied case studies Implementation experiences involving AI, machine learning, or data science 🏆 Top three abstracts will receive $300 travel grants 🗓 Abstract deadline: Wednesday, February 11, 2026 Registration $75 for fellows and graduate students $150 for all other participants Space is limited. Early registration is encouraged. 🔗 Meeting details, abstract submission, travel grants, and registration: asn-online.org/ai What Makes This Workshop Different Kidney care is the core use case, not an afterthought Fully interactive, hands-on sessions using real-world nephrology scenarios Simulation-based exercises focused on clinical workflows and implementation challenges Every participant actively works through exercises (personal computer required) Learning Objectives Participants will be able to: Describe core AI concepts and their relevance to healthcare delivery Demonstrate practical applications of AI in kidney care settings Identify personal competencies and gaps related to responsible AI use through guided tutorials These initiatives reflect ASN’s commitment to building responsible, clinically grounded, and workforce-ready AI literacy across nephrology. I strongly encourage fellows and trainees to take advantage of this unique learning opportunity and to share this within your programs. Hotel Accommodations There is no designated conference hotel or room block to allow attendees flexibility in choosing accommodations that fit their preferences. A list of recommended hotels is available. Questions regarding logistics can be directed to Crystal Johnson, Director of Communications and Events, Renal Research Institute (RRI) 📧 crystal.johnson@rriny.com I, Wisit Cheungpasitporn will personally be joining and am honored to speak and discuss hands-on AI in nephrology and kidney care education together. See you everyone. — Wisit Cheungpasitporn, MD ASN AI Steering Committee

So proud of our incredible Mayo Nephrology fellows. Every day they put patients first, lead with compassion, and commit to excellence through hard work and education.

Congratulations to Dr. Nabeel Aslam, the new president of the Florida Society of Nephrology. We are lucky to have the opportunity to learn and work with him here at Mayo Clinic Nephrology, where he is a core faculty member and educator of fellows.

Appreciative of the birthday wishes and savory (who can say no to sugar and caffeine) gifts of two fantastic nephrology fellows, Dr. Henderson and Dr. Ovincy. In this picture, I appear dwarfed physically, and I look forward to their future careers where they will do so there.

We are excited to share our General Nephrology Fellows that will be joining us in 2026! Wishing the best for all new nephrology fellows and training programs.

journals.lww.com/jasn/fulltext/… 😊🙏🏻🤝 Excited and grateful to share our latest work from the American Society of Nephrology @ASNKidney AI Workgroup and AI Steering Committee! 📘 “Responsible Use of Artificial Intelligence to Improve Kidney Care” 🧩 Journal of the American Society of Nephrology (JASN) – Published online November 7, 2025 @asnpublications journals.lww.com/jasn/fulltext/… Key Highlights: 🌍 AI is moving from concept to clinical reality in nephrology—transforming care in CKD, AKI, dialysis, and transplantation. ⚖️ The statement provides a comprehensive framework for ethical, transparent, and patient-centered AI adoption across all domains of kidney care. 👩‍⚕️ Two guiding goals: Develop AI that genuinely benefits kidney patients. Ensure clinicians remain continuously involved in AI-driven decisions. 💡 Core principles: Transparency, robustness, accountability, equity, and continuous learning. 🧬 CKD early detection: Klinrisk model (AUC 0.80–0.88; 5.8M patients) KidneyIntelX (AUC 0.74–0.77) Smartphone-based albuminuria tools (Minuteful) enabling home CKD screening. 🚨 AKI & critical care: Reinforcement learning models for CRRT optimization and predictive AI for early AKI detection. 💉 Dialysis: AI-guided ESA dosing and anemia control Intradialytic hypotension prediction Vascular access AI monitoring LLMs for multilingual dialysis education and documentation. 🫁 Transplantation: AI-enhanced KDPI/EPTS matching promoting equity and efficiency iBox recognized by EMA as a validated surrogate endpoint for graft survival. 🎓 Education & administration: Generative AI supports journal clubs, adaptive learning, and ambient documentation tools. 🧠 Responsible AI Stack: Data quality & interoperability Rigorous model validation & drift monitoring Clinician-in-the-loop design Patient outcomes focus Governance, ethics & fairness It is an honor to contribute as part of the ASN AI Steering Committee and AI Workgroup in shaping this consensus. If adopted seriously, this statement can help nephrology move beyond scattered pilots toward a coherent, responsible AI ecosystem that improves outcomes for kidney patients worldwide. 🙂🙏 Tagging incredible collaborators and thought leaders driving AI in kidney care: Navdeep Tangri Stanley Crittenden, MD, FASN Alessia Fornoni Carmen A. Peralta, MD,MAS,FASN Karandeep Singh Len Usvyat Amy D. Waterman …and special thanks to Melissa West 🤝 American Society of Nephrology @MayoClinicNeph #AI #Nephrology

MCF Division of Nephrology and Center for Individualized Medicine Support PKD Foundation Fundraiser. Proud to have Dr. Jake Henderson represent our division with support from the fellowship. Dr. Henderson delivered an engaging update on recent advances in PKD research.

It’s always a pleasure and delight connecting with former trainees and now colleagues at conferences. Teamwork, collaboration and lifelong friendship is part of the joy in medicine and at Mayo Clinic Florida.

A strong showing from #MayoClinicFlorida at #KidneyWeek25! Dr. LaTonya Hickson co-moderated the session “Role of the Immune System in CKD,” exploring cutting-edge research on inflammation and kidney disease. Proud to see Mayo leading in both education and scientific discovery.

Exciting #KidneyWeek25 sessions from #MayoClinicFlorida! 🩸 Membranous Nephropathy — Dr. Shane Bobart 🧠 Clinicopathologic Conf. 2: Nephrotic — Drs. Shane Bobart & Nelson Leung Excellence in clinical insight and scholarship! #ASN #Nephrology

Look forward to Dr. Shane Bobart's two presentations tomorrow: Membranous Nephropathy and Clinicopathologic Conference 2: Nephrotic, where Dr. Nelson Leung will take part in the discussion panel at ASN Kidney Week. #MayoClinicKidney #ASNKidneyWeek

We believe a cure for PKD is possible—and we’re committed to making it happen. We’ve just launched the first of many steps. With partnerships and collaboration, we can reach the finish line. If this aligns with your personal or professional goals, we’d love to hear from you! @PKDFoundation

What an honor to participate in the Big Ask Big Give Webinar co-sponsored by @MayoTransplant and the NKF of Florida. Living kidney donor hero’s save lives. For more information about being a donor, visit: mayoclinic.org/livingdonor

Scleroderma renal crisis leaves its mark on the kidney: onion-skin arteriolar thickening, fibrinoid necrosis, and vessel narrowing, classic signs of malignant hypertension driven by relentless vascular injury

Sometimes, “the unsolvable” can be solved. Stay tuned for an upcoming story, where a grateful patient shares their journey @MayoClinic —where our uniquely integrated Mayo team and 12+ collaborating specialists helped diagnose a rare, complex disease that had gone undiagnosed previously. #MayoClinic #RareDisease

Innovation and practice in action! The Mayo Clinic Nephrology Fellowship is helping lead the way with hands-on #POCUS simulation training — equipping tomorrow’s nephrologists with advanced bedside diagnostic skills. Dr. Gregoire with our wonderful fellows in the MCF sim center.

It is difficult to capture in words the appreciation and value of learning, training, and working with dedicated, humble and skilled doctors everyday at Mayo Clinic Florida. Impromptu nephrology-rheumatology table rounds on a complicated patient.

Congratulations to the graduates of MCF Nephrology 2025. We are proud of you, your achievements, and look forward to your future great contributions to medicine as Mayo alumni and colleagues.