Nicole Chambers, PhD

I’m thrilled to share one of my postdoctoral projects in @LabMoehle ! We created a new mouse model of GNAL-linked dystonia which shows overt dystonia-like symptoms and hyperexcitability in striatal SPNs. Thank you to everyone who contributed to this work! biorxiv.org/content/10.110…

In addition to investigating M5 receptor modulation, this study is the first to characterize Erasmus Ladder deficits in the 6-OHDA lesioned mouse. 6/n

Importantly, M5 positive allosteric modulation did not cause robust dyskinesia of its own, nor did it worsen L-DOPA-induced dyskinesia. Overall this suggests targeted M5 receptors modulation as a novel therapeutic target for PD. 5/n

Excited to share my recent first author publication from my postdoc in @LabMoehle ! ⬇️⬇️⬇️ We investigated postive allosteric modulation of M5 muscarinic acetylcholine receptor in the 6-OHDA lesioned mouse model 1/n tinyurl.com/vrfhttm5

We are pleased to announce Dr. Mark Moehle, Ph.D., has been awarded ASPET's 2026 Division for Neuropharmacology Early Career Award! 🎉 Please join us in congratulating Dr. Moehle for this achievement!

180+ neuroscientists & trainees from across US & abroad discussed latest research in Alzheimer’s, Parkinson’s, ALS, dementia @UF-hosted International Research Conference on Neurodegenerative Diseases July 9-12, co-sponsored by the MBI. Learn more: bit.ly/3IqGzzq

Everyone's work day today #SfN

Pathological α-Synuclein Perturbs Nuclear Integrity biorxiv.org/content/10.110… #biorxiv_neursci

Congratulations to our incredible @UF College of Medicine faculty recognized as outstanding or rising star researchers and mentors at the 15th Annual #UFMedResearch Celebration! Meet the winners: news.drgator.ufl.edu/2025/02/07/uf-…. #GoGators

Congrats, Mark!! Well deserved! I’m excited to be among those in @LabMoehle who are presenting research at @UFMedicine Celebration of Research tonight from 5-7.

In this new preprint, Emily Twedell (PhD student) and colleagues identify a functional role for the inhibitory synapses between striatal projection neurons -- shaping striatal ensembles to promote healthy action selection. biorxiv.org/content/10.110…

If you’re still here at @SfNtweets, come and see posters from @LabMoehle ! This morning Iggy presents electrophysiological and cognitive changes in the PFF model of PD and this afternoon I will present electrophysiology and behavioral data from our Gnal linked dystonia mouse.

@postsamnaptic @LabMoehle Thank Sam! I hope that all is well at UNC!

@Nicholinergic @LabMoehle Congratulations Nicole! So awesome to see this in preprint!!

I’m thrilled to share one of my postdoctoral projects in @LabMoehle ! We created a new mouse model of GNAL-linked dystonia which shows overt dystonia-like symptoms and hyperexcitability in striatal SPNs. Thank you to everyone who contributed to this work! biorxiv.org/content/10.110…

@cocacolaFroula @LabMoehle Thank you!!

@Nicholinergic @LabMoehle Great work!! 😄

Rick's dedication to curing dystonia is inspiring, and he will soon be a published expert in the disease that he and @TylersHope is dedicated to curing.

New lab preprint from the outstanding postdoc @Nicholinergic! Here we report new exciting data from a model of GNAL linked #dystonia that we have created. Most importantly, this model shows overt dystonic motor phenotypes, a first for GNAL linked dystonia (1/N).