Jakob Nilsson

Great collaboration with Mailand, Mann and Davey labs.

Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. nature.com/articles/s4159…

Looking forward to a great line up of speakers at #CRISPRMED26 in Copenhagen: linkedin.com/pulse/crisprme… Come join us for some excellent science in the heart of Copenhagen - still places available

We have moved bsky.app/profile/nilsso…

@AdeSaurin weekend project

Glad to see that 20% of the people I follow on X already switched to light side. Reaching critical mass over their and its so easy to switch for those interested in joining...

@AdeSaurin agree

Why are journals insisting on only CRediT statements for author contributions? If people have defined roles (biochemical assays, structural analysis, bioinformatics, supervision of X, etc.) then this info is much more useful than a list of terms that make actual roles ambiguous

We are very excited to open the registration for the upcoming @EMBOevents on Chromosome Segregation and Aneuploidy in beautiful Stresa!!! You can find all the relevant info at meetings.embo.org/event/25-aneup… Hope to see many of you in a few months!! 🧬🔬😍 #ChromoPloidy25

@LindorffLarsen A positively charged name! The alternative is more negatively charged.

The deadline for applications is approaching!!!

@iaincheeseman congrats - look forward to reading this

Our latest work from lab member jimmy Ly! This fundamentally changed the way we see mitosis. Massive rewiring of translational control. There is something for everyone and an amazing mechanism. Check it out.

We (@alexholehouse and @ProteinMagnus) started IDPSeminars in May 2020. It has been a wonderful platform to host an incredible array of international science. What began as a pandemic alternative to conferences has blossomed into a consistent and supportive community.

@lapassmore @MRC_LMB @ERC_Research @RappsilberLab @FJ_OReilly @giselleclee nice - we also found a CCR4-Not motif in ANKRD17 in our latest work with @DaveyLab. Look forward to reading this work more carefully!

New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB @ERC_Research

@molivasantiago @duxin_lab dream on - cup is home

Still buzzing after @duxin_lab retreat! Feeling energised after three days of full of inspiration, fresh perspectives, and some epic fun (gokarts included!). Thanks @NilssonLabCph for joining us on the last day, we'll get the cup back!

Just a few hours into the new year, and the first paper of the year involving our lab has been published🥳 Read about the substrate specificity of the B55 subunit of PP2A and its inhibitor we designed. Great collaboration with @NilssonLabCph, @KettenbachLab and @torbenheick labs!

@FurmanLab @KettenbachLab @torbenheick Thanks Ora and Julia for a great collaboration!

Happy to have been a part of this collaboration with @NilssonLabCph @OraFurman @KettenbachLab @jp_arulanandam. Nice to see it finally out! Substrate recognition principles for the PP2A-B55 protein phosphatase | Science Advances science.org/doi/10.1126/sc…

@wgarland10 @OraFurman @KettenbachLab @jp_arulanandam Thanks for a great collaboration Will and Torben!

An interesting observation for those interested in PP2A-B55 biology is that PME1, the enzyme that removes the C-terminal methyl group on the catalytic subunit causing inactivation of PP2A-B55, contains an N-terminal helix binding directly to B55.

Using this inhibitor we find that it blocks the function of the NEXT complex, a complex involved in nuclear RNA quality control. Consistent with this we find that PP2A-B55 directly binds the RBM7 component of the complex.

Our paper on PP2A-B55 substrate recognition out now. Great collaboration with @FurmanLab @torbenheick @KettenbachLab @jp_arulanandam. We integrate AlphaFold modelling and protein design with biochemical and cell based assays science.org/doi/10.1126/sc…