Giacomo Nuvola MD

The @US_FDA approved the immunotherapy durvalumab with the FLOT chemotherapy regimen before and after surgery followed by single agent durvalumab for adults with resectable gastric or gastroesophageal junction adenocarcinoma: brnw.ch/21wXOZh

🔴In our November issue: Subcutaneous immunotherapy—a wolf in sheep's clothing? Roni Levina, Amol Akhadec, Manju Sengard, and Daniel A Goldstein describe and discuss the growing adoption of subcutaneous formulations and potential future economic effects thelancet.com/journals/lanon…

💡 Key takeaways 💡 • Historic 2-yr relapse ~40%, now lower in current studies • ALBAN had fewer BCG exposures, diff. population • ICI + BCG not yet replacement for BCG alone • Long-term impact on cystectomy & bladder preservation remains open @myESMO @urotoday @Uromigos

⚕️ALBAN (M. Rouprêt) Atezolizumab + BCG vs BCG alone ➡️ No significant benefit in Event-Free Survival (EFS) 🏞POTOMAC (M. De Santis) Durvalumab + BCG (induction + maintenance) vs BCG alone ✅ HR 0.68 → 32% ↓ risk of DFS event 📊 DFS 82% vs 77% at 2 yrs @myESMO @urotoday

🧵 ESMO 2025 – NMIBC Highlights 🧪🩺 1️⃣ Two key Phase III trials in BCG-naïve, high-risk NMIBC show the continuous interest in early-stage disease 👇 @myESMO

Intravesical Gemcitabine via TAR200 for BCG - unresponsive NMIBC with CIS +/- papillary tumors is FDA approved. It joins a number of other agents with a spectrum of MOAs. With data generated from single arm trials there is not a clear winner.

Honored to have our work highlighted in this month’s issue of @Annals_Oncology. Many thanks to my mentor @DrMarkAwad, to @jsmithymd, @StephanieA58255 & all co-authors, and to patients involved in this study. Also special thanks to the editor-in-chief @tompowles1 for selecting it!

What could be the right treatment for papillary #rcc? Ongoing clinical trials will give an answer. Now I am proud to present our global experience just published on @EurUrolOncol Thanks to MatteSantoni all ARON Team! @DrChoueiri @montypal @Uromigos @Uroweb @AIOMtweet @siuroIT

@vmollica7 @fmassari79 @crisuarez08