Oliver Eichmüller

26 posts

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Oliver Eichmüller

Oliver Eichmüller

@OEichmueller

MD Student Studying Neurodevelopment and Disease @Knoblich_lab

Heidelberg, Deutschland Katılım Mart 2019
291 Takip Edilen89 Takipçiler
Oliver Eichmüller retweetledi
Catarina Martins Costa
Catarina Martins Costa@catarinacsmc·
We're at the cover of Cell Stem Cell. We're at the cover of Cell Stem Cell. We're a- (I can barely believe it. 🤯) We found out why some people are born without the main interhemispheric bridge. 🧠 👏 to @PhDexheimer for this beautiful illustration of the corpus callosum.
Cell Stem Cell@CellStemCell

The June issue of CSC is live! The cover story😍😍😍 presents an organoid model of the corpus callosum, shown here as a bridge btwn metaphorical brain hemispheres/city skylines, which @Knoblich_lab used to study white matter defects from Arid1b haploinsufficiency. Read this and more! cell.com/cell-stem-cell…

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The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
📢 Paper alert! Here's our latest @CellStemCell story, led by @catarinacsmc. The corpus callosum safeguards interhemispheric communication in the human brain. 𝘈𝘙𝘐𝘋1𝘉 mutations cause agenesis/absence of the CC. But by which mechanisms? ⤵ tinyurl.com/MartinsCosta20… 🧵1/10
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Catarina Martins Costa
Catarina Martins Costa@catarinacsmc·
🎙️✨ Sharing a glimpse of my research, in an interview to the Impact Award 2023. I am so honoured to have received this distinction for my PhD work exploring the secrets of the human brain! Thank you @univienna 🫶 Watch here ⤵ youtube.com/watch?v=MUBOlZ… Subtitles in 🇵🇹🇬🇧🇩🇪
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University of Vienna STEM@stem_univie

Dive into the fascinating world of #neuroscience with @catarinacsmc, winner of the Impact.Award 2023! She explores the intricacies of human brain development and disease using an innovative approach—brain organoids. 🧠 More on her research project: ⤵ 🔍 youtube.com/watch?v=MUBOlZ…

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The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
📢 We’re live at the @embojournal! 🌐 tinyurl.com/39xdttna Human telencephalic organoids cultured in the absence of Matrigel endogenously produce and self-organize the extracellular matrix, without affecting programs of neuronal differentiation. Led by @catarinacsmc 👩‍🔬 🧵 1/5
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The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
We are thrilled to share our latest work, a collaborative effort with @TreutleinLab, in Nature (nature.com/articles/s4158…). We introduce CHOOSE, a powerful screening system within cerebral organoids, through which we identified developmental defects associated with autism. 🧵1/7
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The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
📣 Preprint alert! Check out our latest story, led by @catarinacsmc. The corpus callosum safeguards interhemispheric communication in the human brain. 𝘈𝘙𝘐𝘋1𝘉 mutations cause agenesis/absence of the CC. We wanted to know why. 🤓 🧵1/9 tinyurl.com/2s4jtr5z
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Catarina Martins Costa
Catarina Martins Costa@catarinacsmc·
Thrilled to share this project with the world! We looked into early morphogenesis of #brain #organoids and characterized the remarkable self-organizing capabilities of the neuroepithelium 🧠 Thanks to everyone in the @Knoblich_lab and beyond who supported me 💜 Go read it! 🤓😋
Catarina Martins Costa tweet media
The Knoblich Lab@Knoblich_lab

📢Preprint alert! Here's our latest story, led by @catarinacsmc Brain organoid morphogenesis can be driven by exogenous ECM (Matrigel), or self-sustained by endogenous ECM production. Late development is mostly independent of the initial ECM source tinyurl.com/5n6n9ss3 🧵1/7

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Oliver Eichmüller retweetledi
The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
📢Preprint alert! Here's our latest story, led by @catarinacsmc Brain organoid morphogenesis can be driven by exogenous ECM (Matrigel), or self-sustained by endogenous ECM production. Late development is mostly independent of the initial ECM source tinyurl.com/5n6n9ss3 🧵1/7
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Veronica Krenn
Veronica Krenn@krenn_veronica·
Fantastic review describing how brain organoids are accelerating the understanding of neurological disorders. Congratulations and thanks to my former and very talented colleague @OEichmueller and the whole @Knoblich_lab for this piece!
The Knoblich Lab@Knoblich_lab

We are thrilled to share our recently published review on understanding neurological diseases in brain organoids! Kudos to @OEichmueller! We hope it will make brain organoid research more accessible and help scientists entering this exciting field. nature.com/articles/s4158…

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Nat Rev Neurology
Nat Rev Neurology@NatRevNeurol·
New online! Human cerebral organoids — a new tool for clinical neurology research dlvr.it/SbNCT5
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The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
5/6 Gruffi can remove stressed cells, improving organoid datasets, which then reveal fetal developmental trajectories.
The Knoblich Lab tweet media
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The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
4/6 Stressed cells are limited to a defined group, that we call stress-identity. It is a cellular state characterized by widespread metabolic changes beyond the activation of stress pathways, which is not found in vivo, therefore need to be removed from #scRNA data.
The Knoblich Lab tweet media
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The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
3/6 We combined transcriptome-wide and gene-set based approaches in Granular Functional Filtering (Gruffi) and found that all analyzed brain organoids contain some stressed cells, but their presence does not affect cell-type specification or neural maturation.
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The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
2/6 Not all cells are created equal – In 3D tissue models, such as brain organoids oxygen & nutritient supply is limited in deep tissue. This leads to cell-stress, but it's extent and consequences are unclear.
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The Knoblich Lab
The Knoblich Lab@Knoblich_lab·
1/6 Stress in #brain #organoids is widely debated: Are all organoids & all cells affected? Does it exist in vivo? Does it impair cell differentiation? Gruffi, our new algorithm identifies and removes stressed cells from #scRNAseq #singlecell datasets. bit.ly/Gruffi
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Keşfet

@CellStemCell @catarinacsmc @univienna @embojournal @TreutleinLab @ETH_en @MedUni_Wien @Knoblich_lab