Owen Davies Lab

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Owen Davies Lab

Owen Davies Lab

@OwenDaviesLab

Structural biology lab focussed on meiotic chromosome synapsis and recombination

University of Edinburgh, UK Katılım Ocak 2019
31 Takip Edilen258 Takipçiler
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Ian R Adams
Ian R Adams@IanAdamsLab·
Save the date! The 2023 British Meiosis Meeting #BMM2023 will be held in Edinburgh on 19-20th April. We have many opportunities for post-docs and students to present - and two amazing colleagues @lab_borde @weir_science as guest speakers. @IanAdamsLab @OwenDaviesLab
Ian R Adams tweet media
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
We have postdoc positions available in structural and cellular biology, studying supramolecular assembly of the synaptonemal complex in meiosis. Contact me directly for information. For details and to apply (deadline 20th January): tinyurl.com/3xbdeu62 tinyurl.com/ycktp2k9
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
Our work on how synaptonemal complex component SYCE2-TEX12 mediates meiotic chromosome synaptic elongation by assembling into 'intermediate filament'-like fibres has just been published in NSMB @NatureSMB: nature.com/articles/s4159…
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
Our structural studies reveal that SUN-KASH complexes are head-to-head 6:6 assemblies, leading to a new model for LINC complex architecture. Now published in eLife: doi.org/10.7554/eLife.…
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
@AminSagar1 Thanks! Yes, the residuals are calculated as theoretical-experimental/errors, so are quite low at high q values since the experimental error is high in this range. The other side is that they pick out significant low q differences that don't look too bad by eye (e.g. grey curve).
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Amin Sagar
Amin Sagar@AminSagar1·
@OwenDaviesLab Beautiful paper. Especially the monsa part. Curious why the residuals don't clearly reflect the fitting. Eg. in Fig 6a, tetramer, the rigid body model curve deviates at wide angles but residuals are flat. Is it because of high std. dev. in that part of curve?
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
Mechanism of SYCE3 self-assembly within the synaptonemal complex revealed through SAXS analysis coupled with molecular modelling, now available in Biorxiv: A molecular model for self-assembly of synaptonemal complex protein SYCE3 biorxiv.org/content/10.110…
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
@LabNeale @ChristineMezard @HarmitMalik This is an excellent idea! It would also encourage people to stay with their posters for the duration of the session. There may need to be a limit on the number to prevent blanket requests . . .
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
Lonely Cyclin B1 molecules are readily exterminated in oocytes. Work from Suzanne Madgwick's lab on Cyclin degradation in meiosis has just been published in Developmental Cell. cell.com/developmental-…
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Owen Davies Lab retweetledi
ccp4_mx
ccp4_mx@ccp4_mx·
And last up for today Owen Davies' talk: CCP4 SW2019 - Solving coiled coil structures through unconventional MR m... youtu.be/CkpQxnH-C3I via @YouTube
YouTube video
YouTube
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
It doesn’t always require a crystal to solve the structure of a coiled-coil protein! Our paper on the structure of synaptonemal complex protein SYCE1, determined by solution small-angle X-ray scattering, is now available on-line. rdcu.be/bfGC2
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
We have a PhD position available to study the structure of the synaptonemal complex through cryo-EM, X-ray crystallography and biophysics. Application deadline 11th January. findaphd.com/phds/project/t…
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Owen Davies Lab
Owen Davies Lab@OwenDaviesLab·
Our paper on meiotic telomere tethering to the nuclear membrane by MAJIN-TERB2-TERB1 has now been published in Nature Communications doi.org/10.1038/s41467…
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