Owen Davies Lab

Save the date! The 2023 British Meiosis Meeting #BMM2023 will be held in Edinburgh on 19-20th April. We have many opportunities for post-docs and students to present - and two amazing colleagues @lab_borde @weir_science as guest speakers. @IanAdamsLab @OwenDaviesLab

Our work on the structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3 has now been published in @NatureSMB. This biochemical and mouse genetics paper resulted from an excellent collaboration with @IanAdamsLab. nature.com/articles/s4159… rdcu.be/c3i5E

We have postdoc positions available in structural and cellular biology, studying supramolecular assembly of the synaptonemal complex in meiosis. Contact me directly for information. For details and to apply (deadline 20th January): tinyurl.com/3xbdeu62 tinyurl.com/ycktp2k9

Our work on how synaptonemal complex component SYCE2-TEX12 mediates meiotic chromosome synaptic elongation by assembling into 'intermediate filament'-like fibres has just been published in NSMB @NatureSMB: nature.com/articles/s4159…

Our structural studies reveal that SUN-KASH complexes are head-to-head 6:6 assemblies, leading to a new model for LINC complex architecture. Now published in eLife: doi.org/10.7554/eLife.…

Our collaborative work with Alberto Pendas on the synaptonemal complex SYCE1-SIX6OS1 interaction and its role in infertility has just been published in Science Advances: advances.sciencemag.org/content/6/36/e…

Here's an exciting, multi-disciplinary BBSRC PhD opportunity with @OwenDaviesLab (mainly; xtal, cryoEM) and me (bioinformatics) on the structural biology of meiotic recombination. Cancer drug targets too. @LivUniLifeSci @livuniIIB @FHLSPGR findaphd.com/phds/project/t…

Our paper on the mechanism of SYCE3 self-assembly has now been published in JBC: jbc.org/cgi/content/lo…

@AminSagar1 Thanks! Yes, the residuals are calculated as theoretical-experimental/errors, so are quite low at high q values since the experimental error is high in this range. The other side is that they pick out significant low q differences that don't look too bad by eye (e.g. grey curve).

@OwenDaviesLab Beautiful paper. Especially the monsa part. Curious why the residuals don't clearly reflect the fitting. Eg. in Fig 6a, tetramer, the rigid body model curve deviates at wide angles but residuals are flat. Is it because of high std. dev. in that part of curve?

Mechanism of SYCE3 self-assembly within the synaptonemal complex revealed through SAXS analysis coupled with molecular modelling, now available in Biorxiv: A molecular model for self-assembly of synaptonemal complex protein SYCE3 biorxiv.org/content/10.110…

@LabNeale @ChristineMezard @HarmitMalik This is an excellent idea! It would also encourage people to stay with their posters for the duration of the session. There may need to be a limit on the number to prevent blanket requests . . .

What do you think of this idea for EMBO meiosis 2019 @ChristineMezard @HarmitMalik ?

Lonely Cyclin B1 molecules are readily exterminated in oocytes. Work from Suzanne Madgwick's lab on Cyclin degradation in meiosis has just been published in Developmental Cell. cell.com/developmental-…

And last up for today Owen Davies' talk: CCP4 SW2019 - Solving coiled coil structures through unconventional MR m... youtu.be/CkpQxnH-C3I via @YouTube

It doesn’t always require a crystal to solve the structure of a coiled-coil protein! Our paper on the structure of synaptonemal complex protein SYCE1, determined by solution small-angle X-ray scattering, is now available on-line. rdcu.be/bfGC2

We have a PhD position available to study the structure of the synaptonemal complex through cryo-EM, X-ray crystallography and biophysics. Application deadline 11th January. findaphd.com/phds/project/t…

Our paper on meiotic telomere tethering to the nuclear membrane by MAJIN-TERB2-TERB1 has now been published in Nature Communications doi.org/10.1038/s41467…