Prof Paul Beavis

Fantastic to see this work led by @JunyunLai and @mardianasherlz published today. Culmination of many years work in two @PeterMacRes buildings! Look forward to developing this approach further.

#sol=26902c58cbf4eed2d4eff8a2dc1787d8ee767af1" target="_blank" rel="nofollow noopener">seek.com.au/job/90919914?t…

We are recruiting for a post-doctoral researcher to work in our lab under the supervision of Dr. Isabelle Munoz. (See link in comments) The research @PeterMacRes is on novel approaches to enhance the efficacy of CAR T cell therapy. Please send an email for further details

We are looking for a Project Manager to facilitate a new program of work centered around a novel CAR T technology that will lead to a phase I trial & development of novel assets. Please see details below for role description and for further details.

@DelgoffeLab Congratulations- very well deserved 🙌

Honored to be elected and excited to help support the future of cancer immunology!

Nature research paper: Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery go.nature.com/4le7GMB

Pleased to present the latest work from the lab published in @NatureComms in work led by @kevin_sek: nature.com/articles/s4146…

I’d like to congratulate @kevin_sek for many years of hard work, all members of the group for this collaborative study and Phil Darcy who co-led the work. We would also like to thank funders of the work including @nhmrc @NBCFAus and @CancerVic and our consumer representatives.

We were able to show this was therapeutically useful and the gene program induced by A1R expression was distinct to simply Knocking out A2AR, suggesting there may be synergy between these pathways.

@may_daher Thanks for the kind words May!

Congratulations @paulbeavis4 and team on this beautiful story. Very promising approach using armoured CAR-T cells designed to enhance efficacy while decreasing toxicity, with high translational value for solid tumors. Looking forward to seeing responses in patients with solid tumors using this approach! #CART #armoredCAR #solidtumors

@dbgoodman Thank you for the kind words Daniel!

Very elegant approach - put CAR-T cytokine payloads under the control of loci that are upregulated in T cells within the tumor microenvironment to avoid systemic tox. Also KO suppressive gene in the process. Pleased to see that this worked so well!

Dedicating my first post on X to share some exciting news — our work is out today in @Nature! 🎉 Co-first authored with the amazing lab buddy @_amandachen, and guided by our incredible supervisors @paulbeavis4, Phil & @ImranHouse. nature.com/articles/s4158…

In the news today: Peter Mac scientists have developed “Precision Guided Munition” CAR T-cells – smart immune cells that target solid tumours directly. In lab models, they wiped out breast, colon & ovarian tumours with cure rates near 100%! More: petermac.org/about-us/news-…