Paul Gamble PhD
3.5K posts
@PaulGamblePhD
Coach, performance director and author. Formerly @londonirish @scottish_squash and others. Consulting enquires @InformedinSport My substack is AthleteGeneration
In December 2025, former US Senator @BenSasse announced that he had been diagnosed with stage 4 pancreatic cancer. That's the primary topic for this @UncKnowledge conversation about mortality, faith, and what truly matters when time is short. Talking to host @P_M_Robinson, Sasse reflects on "redeeming the time"—holding ambition lightly, loving family more deliberately, and resisting the urge to make politics or professional success the center of life. The discussion also covers Sasse's thoughts on the failures of Congress; the dangers of a fragmented, attention-starved republic; the crisis of higher education; and the moral challenges of technological abundance. He speaks candidly and movingly about regret, forgiveness, prayer, and suffering—arguing that while death is a real enemy, it does not get the final word. Watch the full conversation on X:
Breaking news in #PancreaticCancer research! Spanish oncologist Mariano Barbacid’s team at CNIO just achieved complete regression of KRAS mutated pancreatic tumors in mice using a low toxicity drug combo, RMC-6236 (KRAS inhibitor), afatinib (EGFR inhibitor) & SD36 (STAT3 degrader). No relapse, minimal side effects & a huge step toward beating resistance!
