Peersen Lab

A new update (v4) to the polymerase structure alignments is available on Zenodo - this July 2022 release has 917 structures from 628 PDB entries. zenodo.org/record/6859370 mdpi.com/1999-4915/11/8…

The polymerase of #coronavirus #SARSCoV2 can adopt an alternative structure: an antiparallel dimer with only one nsp8 that may bind only one nsp13. We speculate the dimer facilitates template switching and synthesis of subgenomic viral #RNA. Manuscript: biorxiv.org/content/10.110…

A long overdue update to my structure alignments - now up to 802 structures from 534 PDB entries. Includes 21 CoV nsp12 solved in the last year. Polymerase Structure Alignments - v3 Update (March 2021) doi.org/10.5281/zenodo…

Our paper describing the #coronavirus RNA polymerase structure is online. The nsp8 extensions contact RNA far away from the active site, apparently enabling processive replication of the very long #SARSCoV2 genome. Publication: nature.com/articles/s4158… PR: mpibpc.mpg.de/17275755/pr_20…

New paper on SARS nsp12 polymerase biochemistry, drug incorporation, and virology from my great sabbatical with @canardbruno @AFMBLab. biorxiv.org/content/10.110…

Thanks to A Shannon F. Ferron and the Canard team: Remdesivir and SARS-CoV-2: structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites sciencedirect.com/science/articl…

Due to public health concerns regarding the COVID-19 pandemic, ASV 2020 has been cancelled. Please see our full statement here: asv.org/asv2020stmt

#ASV2020 Program and abstract submission are now live at ASV2020.com. Coming/opening soon: registration, residence hall registration, travel award and ASVCares applications, and *NEW* for 2020, onsite childcare. #LoveVirology

@canardbruno Thanks for the shoutout, Bruno. This is an evolving project and I’m more than happy to take suggestions for new/improved alignments or analyses. It’s a resource for polymerase geeks, and perhaps some instructors.

Polymerase Structure Alignments - v2a Update (October 2019) New structures of L proteins from RSV and HMPV, picornaviral polymerases with a Ser1 residue, bluetongue virus polymerase, more flu structures, and a FMDV 3Dpol. doi.org/10.5281/zenodo…

@VignuzziLab One of your favorite conference venues, as I recall. If it wasn’t already sunny here in Marseille I would consider it 😄.

Ready for the European Viral Zoonoses meeting in beautiful Saint Raphaël. But first, sun. Then, science. Just like Mom taught me. Priorities.

My years long project aligning viral polymerase structures is finally out - details in the Viruses paper below and all the coordinates can be found on Zenodo - zenodo.org/communities/po… ... soon to be updated with the latest structures mdpi.com/1999-4915/11/8…