PeptideTracker

Our peptide tracker and calculator is live on the App Store!

Shoulda raised for a Peptide start up Martha

This guy is in the trenches comparing and testing peptides for your benefit. Follow!

@_9th_Life_ Nice thread

Beginner guide to GLP1 peptides: Semaglutide. The Toyota of weight loss peptides. You've definitely heard of Ozempic, this is the one that kicked off the hype. Ozempic and Wegovy are the same molecule, the difference is the use case: Wegovy is FDA approved for weight loss, Ozempic for type 2 diabetes. Most FDA-approved uses of any GLP-1. Both developed by Novo Nordisk. ~15% weight loss at 68 weeks. Widely adopted, gets the job done. Tirzepatide. The Audi of weight loss peptides. Same platform, better biological engineering. Targets two hormones (GLP-1 + GIP). Stronger results, less nausea, better lean mass retention. ~21% weight loss at 72 weeks. FDA approved for chronic weight management, glycemic control in type 2 diabetes, and obstructive sleep apnea. Like semi it has two brand names: Mounjaro for type 2 diabetes, Zepbound for chronic weight management. Once-weekly injection. Made by Eli Lilly. Retatrutide. The Lamborghini of weight loss peptides. First-in-class triple hormone receptor agonist. Targets three hormones (GLP-1 + GIP + glucagon). Burns fat directly on top of appetite suppression. Phase 2 showed 24% at 48 weeks. Phase 3 TRIUMPH-4 just hit an average of 71.2 lbs lost at 68 weeks on the 12mg dose, the highest weight loss ever recorded in an obesity trial. Also lowered systolic BP by 14 mmHg and cut triglycerides, non-HDL cholesterol, and hsCRP. Still in Phase 3, not FDA approved yet. Seven more Phase 3 readouts expected through 2026. Also made by Eli Lilly. What GLP-1, GIP, and glucagon do in the body: GLP-1 -> released by L-cells in your gut when you eat. Tells your brain you're full, tells your pancreas to release insulin, slows stomach emptying. Your natural "I'm done eating" signal. Half-life of about 2 minutes. These peptides were engineered to last days. GIP -> released by K-cells in your gut when you eat. K-cells are specialized sensor cells in the lining of your duodenum and upper small intestine that detect incoming nutrients (glucose, fat, amino acids) and signal the rest of your metabolism that food has arrived. On its own GIP promotes fat storage and barely touches appetite. Paired with GLP-1, the combo amplifies insulin sensitivity, enhances fat oxidation, and improves how your body handles lipids. Glucagon -> released by alpha cells in your pancreas when blood sugar drops, you're fasting, exercising, or eating a high-protein meal. It's the direct counterweight to insulin. Triggers your liver to dump stored glycogen, blocks the liver from storing more, and creates brand new glucose from amino acids and fat (gluconeogenesis). This is what drives the increase in energy expenditure with reta and the direct fat-burning effect. These peptides are injectable versions of hormones your body already makes, just stronger and longer lasting. Practical differences: Semi -> most data behind it, most widely adopted, the Toyota Camry of the category Tirz -> sweet spot for most people, GIP blunts the GI side effects for a smoother ride, the Audi Reta -> strongest, fastest, glucagon adds direct fat burn and better lipid/liver markers, but resting HR bump and side effects more pronounced at high doses, the Lambo How people gain access: Semi and tirz -> Two options. #1: consult a doctor and get the brand or compounded version prescribed. #2: gray market, research labs producing the peptide "not for human consumption." Option 1 you're a patient, option 2 you're a lab rat. Reta -> Lab rat methods only. #1: gray market vendors, where most people are sourcing it since it isn't FDA approved. #2: enroll in an Eli Lilly clinical trial. Either way you're a lab rat. Lilly is building the Lambo, it's just still in R&D. Different metabolic vehicles, different companies, same lot. Each tier adds horsepower, results, and side effect potential.

The biggest mindset shift coming from peptides: many limitations we thought were fixed features of human biology might actually be adjustable through targeted signaling molecules.

Mind boggling how big the TAM for biotech and peptides will become

Incredible things happening in the peptide space

Nice thread on MOTS-c

Semax and Selank come from Russian research and have developed cult followings for delivering calm focus and mental clarity without the jittery feeling of traditional stimulants.

Insulin is technically peptide. Retatrutide is a synthetic peptide. Your body already produces millions of peptides naturally. The current hype is about using targeted synthetic versions for specific benefits.

Incredible Peptide guide for those interested

@alc2022 We remain bullish 🔥

$HIMS fundamentals are in extraordinary shape All important metrics came in at or near ATHs, with tough YoY comps $HIMS is now a two sided healthcare operating system Still, investors continue to sell their shares at irrationally low prices Thank you very much!

Peptides are the future of medicine

@kevinxu Weak hands

NEW TRADE: SOLD $HIMS AND FULL PORTED $QS Driving right now. Full thesis coming soon.

That man is on r3ta honey

New product roadmap just dropped

Babe I’m going on a diet

The peptides will rise again don’t you worry

@kevinxu Oversold, let the spice (peptides) flow

call me crazy but i'm not quite convinced $HIMS ends this down -10%. volume is too low. earnings call in 15 min.

PEPTIDE (TRACKING) SUPERCYCLE

$HIMS with one of the best founders out there @AndrewDudum