Peters Lab

Just wrapped up another incredible Annual Meeting! Over 200 FMI scientists, Novartis colleagues and the FMI Scientific Advisory Board came together for insightful talks, engaging posters, and fun activities. Thanks to everyone who made it a success, looking forward to next year!

Today Dr. Mark Gill presented to @ESHRE how NicE-view detects the levels of DNA accessibility in human sperm across individuals with differing reproductive parameters. Find more here: biorxiv.org/content/10.110…

Excited to present our latest research at the European Society of Human Reproduction and Embryology conference @ESHRE ! Join Devico Shi and Dr. Mark Gill from @FMIscience and @UniSpitalBasel to explore the chromatin organization of mouse and human sperm!

Congratulations to all of the authors, and many thanks to the staff of the Andrology lab at the University Hospital Basel and the facilities at the FMI, without whom this work would be not have been possible.

We also show that a high frequency of sperm with high levels of DNA accessibility correlates with poor reproductive outcomes. All the participants in this study had normal fertilization rates, suggesting a post-fertilization function for sperm DNA packaging in human development.

Happy to share our new preprint “Levels of DNA accessibility in human sperm vary across individuals with differing reproductive parameters” (biorxiv.org/content/10.110…) the result of a fruitful collaboration with the University Hospital Basel. @FMIScience @UniSpitalBasel

Great support from FMI (@FMIscience) and Reproductive Medicine and Gynecological Endocrinology, University Hospital Basel (@UniSpitalBasel).

We anticipate that this protocol will facilitate reproductive biology research. We would like to thank Hubertus Kohler from FMI FACS facility and Antoine Peters (@AntoinePeters8 ) for their contributions.

Happy to share the method regarding the “Isolation of Mouse Germ Cells by FACS Using Hoechst 33342 and SYTO16 Double Staining“ developed by Mark Gill published as a chapter of the Germ Cell Development Methods and Protocols book. doi.org/10.1007/978-1-…

Thanks to all authors of the study Laura Gaspa-Toneu, Evgeniy Ozonov (@EvgenOzonov), Pavel Komarov, Sebastian Smallwood and Antoine Peters (@AntoinePeters8) at @FMIscience, FMI facilities and funding agencies @snsf_ch , @ERC_Research and @NovartisScience !

Our study provides proof of concept linking deposition of H3K4me3 on the paternal genome in early embryos to the DNAme status inherited from sperm. Understanding how chromatin transmits information across generations continues to be an exciting question!

@PetersLabFMI: Excited to share our latest preprint lead by Greg Fanourgakis (@Grigo_Fanou). Key findings are that DNA methylation modulates nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos. biorxiv.org/content/10.110…

This work was led by Daniel Ballmer, Mathieu Tardat, Grigorios Fanourgakis @grigo_fanou and Antoine Peters @AntoinePeters8 along with the great support of imaging facility expert Alexandra Graff-Meyer at FMI @FMIscience.

@PetersLabFMI: Happy one year publication anniversary at Nucleic Acid Research @NAR_Open for this beautiful work on how "HP1 proteins regulate nucleolar structure and function by secluding pericentromeric constitutive heterochromatin" !!! academic.oup.com/nar/article/51…