Petr Pavek

Today, the International Scietific Advasory Bord gives positive recommendations to out OP JAK project NETPHARM. Thank to all participants and institutions. #CzechScience #DrugDevelopment

Best researchers involved in drug and delivery system development from Charles University, IOCB Prague, IMC, CEITEC and UCT will join to present progress in their research. #CharlesUniversity #IOCBPrague #VSCHT #CEITEC #IMCPrague #CzechScience #DrugDevelopment #CzechScience

The 2nd Annual Conference of the NETPHARM Project on New Technologies for Translational Research in Pharmaceutical Sciences will take place on 15–16 May 2026. NETPHARM is the largest national project focused on drug development. netpharm.cz/en

Ozempic and GLP-1 cause weight loss via the vagus nerve. In people whose vagus nerve was surgically cut (below the diaphragm, not in the neck), GLP-1 did not reduce food intake or accelerate metabolism. These drugs work through the vagus, in ways we still do not fully understand.

Komunikace s AI: Já: jsi chytrej, díky. 😄 díky! To potěší. Já mám jen dobrý tahák a hodně kávy v serverovně.

Statins have less side effects than we thought. Cognitive impairment, depression, sleep disturbance, and peripheral neuropathy not confirmed in large metanalysis x.com/TheLancet/stat…

faf.cuni.cz/Public/News/20… Our project CLEAR advanced to the second evaluation stage in the EIC Transition call, and we were interviewed with the EIC jury (only 16% of projects were evaluated in the 2nd stage). Unfortunately, we did not get financing.

Saint Ivo(Ives) patron saint of lawyers, statue on Charles Bridge. The seagull on his head shows no respect for legal justice.

Potenciál malých molekul jako léčiv ještě nebyl vyčerpán. V loňském roce jich bylo schváleno 34. Brensocatib, první inhibitor DPP1 pro bronchiektázii, a inhibitor sodíkových kanálů NaV1.8 suzetrigin jako analgetikum jsou považovány za "trháky". Jsou to léky první ve své třídě.

The potential of small molecules as drugs has not yet been exhausted. 34 of them were approved last year. Brensocatib, the first DPP1 inhibitor for bronchiectasis, and the NaV1.8 sodium channel inhibitor suzetrigine are considered megablockbusters. They are first in class drugs.

Christmas meeting of experimental hepatologists from Hradec Kralove-Pavek's, Micuda's and Trejtnar's labs

@Eva46653369 Very nice bioRxiv paper. Congrats!

🎯 Bile acids are signaling molecules whose physiological actions are expanding far beyond digestion, excretion & metabolism. Bile acids regulate crucial Glucocorticoid Receptor actions opening new avenues for pharmacological avenues 💊⚡️🔥

I think we should remember the term NOVOKINES, which could soon appear in therapy (see the article by David Baker's lab). NOVOKINES, artificial cytokines, could expand therapeutic options in the treatment of autoimmune diseases.

The Nobel Prize in Physiology or Medicine 2025 to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.” Seattle, San Francisco, Osaka.

linkedin.com/feed/update/ur… Echo of the ICCP450 conference in Bern.

"Open Science" je "Green deal" vědy. Vědci se ozvali. vedavyzkum.cz/analyzy/analyz…

@Eva46653369 @nurcamein I mourn the loss of the distinguished scientist who, among other things, discovered the PXR receptor.

We are heartbroken to learn about the passing away of David Mangelsdorf. Only a few weeks ago he was delivering in San Francisco #ENDO2025 an amazing and amusing talk together with Steve Kliewer. The Spanish Nuclear Receptor @nurcamein community is mourning his loss.

#ICCP450 @Pandeylab @iccp450 It was a great ICCP450 conference in Bern. Thank you, Amit!

40 let stará struktura cytochromu P450 kreslená rukou a tužkou! Počítače se jestě nepoužívaly.