PhageCast

In Crohn’s disease, the intestinal barrier is damaged. As Luisa explains “We look at translocation because the gut is hyperpermeable and over-inflamed.” What do you think happens with gut viruses then? Tune in to hear the answer! open.spotify.com/episode/2rE4pC…

In our last episode, we interview @luisadesordi and talk about how bacteriophages shape inflammation and may even cross the intestinal barrier in Crohn’s disease to get to the blood. Tune in to hear the new episode! open.spotify.com/episode/2rE4pC…

Throughout the conversation, we focus on the biological mechanisms underlying phage translocation and what these findings suggest about the gut–blood virome axis in inflammatory disease. We also asked some personal questions and got some valuable advice! Enjoy the episode!

The study shows that certain phages translocate at higher levels in Crohn’s patients. We also cover the experimental approach used to track phages across epithelial layers, including fluorescent labeling and other methods and questions they answered!

In this episode, we speak with @luisadesordi (Sorbonne University) about her research on gut phages and their role in Crohn’s disease. We discuss whether phages can cross the intestinal barrier into the bloodstream and how this differs in healthy individuals vs. Crohn’s patients.

Stay until the end of this episode to hear about Célia’s journey as a PhD student, what she’s most proud of, and her transition from academia to industry. 🎧 Listen now: open.spotify.com/episode/4D6WrX…

What are tailocins, and how do they differ from phages or endolysins? How can we express them? In this episode with Célia Pas, we discuss their biology, mode of action, and why they are relevant for targeting Gram-negative bacteria. Enjoy the episode! open.spotify.com/episode/4D6WrX…

We close the episode with Célia’s personal experience as a PhD student, discussing the challenges of this work, what she is most proud of, and her transition toward industry along with practical advice for early-career researchers considering similar paths.

Throughout the episode, we cover: What tailocins are, how they differ from phages and endolysins? Why targetting Gram-negative pathogens like E. coli and K. pneumoniae? What the VersaTile technique is, how it works, and why it offers a flexible and much more!

In today’s episode of Phagecast, we interview @CliaPas1, to dive deep into the world of tailocins and how they can be engineered as highly specific antibacterial tools. Do bacteriophages get inactivated by the complement system, or can both act together against bacteria?

Do bacteriophages get inactivated by the complement system, or can both act together against bacteria? Have you heard about serum preconditioning of bacteria and how it affects phage killing? Check out our latest PhageBites episode with Carmen Chen: open.spotify.com/episode/2MYwvD…

Stay until the end to hear about Carmen’s experience as a PhD student, what she found most challenging, and her personal insights from working at the interface of phage biology and host immunity. Enjoy!

We discuss the main experiments and results, including serum and phage pre-conditioning, the role of capsular and phase variation in clinical strains, and how these factors affect phage susceptibility.

In our latest PhageBites episode, we talk with Carmen Chen. She walks us through her recent paper, “Antibiotic-resistant Acinetobacter baumannii can be killed by a combination of bacteriophages and complement”, and explains how phages interact with the human complement system.

New Year and a New PhageCast episode out! New Phagebite episode, this time with Carmen Chen, MSCA PhD student in Finland and Milan, on how bacteriophages interact with the human complement system to kill antibiotic-resistant A. baumannii. Listen to here: open.spotify.com/episode/2MYwvD…

Phage research in animals moves faster, clearer endpoints, simpler data, real-world cases in poultry & Salmonella. So why isn’t it scaling faster? Funding and regulation. Prof. Martha Clokie explains what’s realistic today 🎙️ open.spotify.com/episode/2GZzbT…